scholarly journals Obesity, menstrual irregularity and polycystic ovary syndrome in young women with type 1 diabetes: A population‐based study

2020 ◽  
Vol 93 (5) ◽  
pp. 564-571
Author(s):  
Eleanor P. Thong ◽  
Frances Milat ◽  
Anju E. Joham ◽  
Gita D. Mishra ◽  
Helena Teede
Keyword(s):  
Type 1 Diabetes ◽  
Polycystic Ovary Syndrome ◽  
Young Women ◽  
Polycystic Ovary ◽  
Population Based ◽  
Menstrual Irregularity ◽  
Ovary Syndrome ◽  
Population Based Study

MENSTRUAL DISORDERS AND ANDROGEN-RELATED TRAITS IN YOUNG WOMEN WITH TYPE 1 DIABETES MELLITUS: A CLINICAL STUDY

2020 ◽  
Vol 26 (11) ◽  
pp. 1269-1276
Author(s):  
Stavroula A. Paschou ◽  
Andromachi Vryonidou ◽  
Marina Melissourgou ◽  
Ioanna Kosteria ◽  
Dimitrios G. Goulis ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Polycystic Ovary Syndrome ◽  
Type 1 Diabetes Mellitus ◽  
Young Women ◽  
Polycystic Ovary ◽  
Menstrual Disorders ◽  
Ovary Syndrome ◽  
Pcos Group

Objective: To investigate possible causes of menstrual disorders and androgen-related traits in young women with type 1 diabetes mellitus (T1DM). Methods: Fifty-three women with T1DM (duration 8.0 ± 5.6 years), 41 women with (polycystic ovary syndrome) PCOS, and 51 controls matched for age (19.4 ± 4.3 years vs. 21.2 ± 2.7 years vs. 20.8 ± 3.1 years; P>.05) and body mass index (BMI) (22.2 ± 2.7 kg/m2 vs. 21.9 ± 2.0 kg/m2 vs. 21.4 ± 1.9 kg/m2; P>.05) were prospectively recruited. Results: Two women (3.8%) in the T1DM group had not experienced menarche (at 15.5 and 16.6 years); of the rest, 23.5% had oligomenorrhea, 32.1% hirsutism, and 45.3% had acne. The age at menarche was delayed in the T1DM group compared to controls (12.7 ± 1.3 vs. 12.0 ± 1.0 years; P = .004), while no difference was observed with the polycystic ovary syndrome (PCOS) group (12.4 ± 1.2 years). There were no differences in total testosterone (0.43 ± 0.14 ng/mL vs. 0.39 ± 0.14 ng/mL; P>.05), dehydroepiandrosterone sulfate (DHEA-S) (269 ± 112 μg/dL vs. 238 ± 106 μg/dL; P>.05) or Δ4-androstenedione (2.4 ± 1.3 ng/mL vs. 1.9 ± 0.5 ng/mL; P>.05) concentrations between T1DM and controls. However, patients with T1DM had lower sex hormone binding globulin (SHBG) concentrations than controls (61 ± 17 nmol/L vs. 83 ± 18.1 nmol/L; P = .001), which were even lower in the PCOS group (39.5 ± 12.9 nmol/L; P = .001 compared with T1DM). The free androgen index (FAI) was higher in the PCOS group compared with both other groups (T1DM vs. PCOS vs. controls: 2.53 ± 0.54 vs. 7.88 ± 1.21 vs. 1.6 ± 0.68; P<.001). FAI was higher in patients with T1DM compared to controls as well ( P = .038). There was no difference in DHEA-S concentrations between T1DM and PCOS patients (269 ± 112 μg/dL vs. 297 ± 100 μg/dL; P>.05). Conclusion: Menstrual disorders and androgen-related traits in young women with T1DM may be attributed to an increase in androgen bioavailability due to decreased SHBG concentrations. Abbreviations: Δ4A = Δ4-androstenedione; BMI = body mass index; CI = confidence interval; CV = coefficient of variation; DHEA-S = dehydroepiandrosterone sulfate; FAI = free androgen index; HbA1c = glycated hemoglobin; PCOS = polycystic ovary syndrome; RIA = radioimmunoassay; SHBG = sex hormone binding globulin; T1DM = type 1 diabetes mellitus

Serum anti-Müllerian hormone concentration in women with polycystic ovary syndrome and type 1 diabetes mellitus

Metabolism ◽  
2016 ◽  
Vol 65 (5) ◽  
pp. 804-811 ◽  
Author(s):  
Agnieszka Łebkowska ◽  
Agnieszka Adamska ◽  
Monika Karczewska-Kupczewska ◽  
Agnieszka Nikołajuk ◽  
Elżbieta Otziomek ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Polycystic Ovary Syndrome ◽  
Type 1 Diabetes Mellitus ◽  
Polycystic Ovary ◽  
Hormone Concentration ◽  
Ovary Syndrome

Fecundity among women with polycystic ovary syndrome (PCOS)—a population-based study

2019 ◽  
Vol 34 (10) ◽  
pp. 2052-2060 ◽  
Author(s):  
S Persson ◽  
E Elenis ◽  
S Turkmen ◽  
M S Kramer ◽  
E-L Yong ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Cox Regression ◽  
Polycystic Ovary ◽  
Nordic Country ◽  
Reproductive Potential ◽  
Population Based ◽  
Fertility Treatment ◽  
Cumulative Probability ◽  
Ovary Syndrome ◽  
Population Based Study

Abstract STUDY QUESTION Does the long-term fecundity of women with polycystic ovary syndrome (PCOS) differ from those without PCOS? SUMMARY ANSWER Cumulative probability of childbirth is similar between women with and without PCOS. WHAT IS KNOWN ALREADY PCOS is the main cause of anovulatory infertility in women after menarche. Previous studies indirectly suggest that fecundity in women with PCOS over the longer term may not be lower than in women without PCOS. STUDY DESIGN, SIZE, DURATION This is a population-based study using four linked Swedish national registries. A total of 45 395 women with PCOS and 217 049 non-PCOS women were included. Follow-up began at the age of 18 years and continued for a maximum of 26 years, from 1989 to the end of 2015. Childbirth was the main outcome, as identified from the Medical Birth Register. PARTICIPANTS/MATERIALS, SETTING, METHODS All women born between 1971 and 1997 who were identified with a PCOS diagnosis in the Swedish Patient Registry between 1 January 2001 and 31 December 2016 were included in the study population. Five controls per women with PCOS were randomly drawn from the Total Population Registry. The control women were born in the same year and living in the same municipality as the patient. The fecundity ratio (FR) was calculated by clustered Cox regression using a robust variance, adjusted for maternal birth period, country of birth and level of education. MAIN RESULTS AND THE ROLE OF CHANCE The cumulative probability of childbirth was 80.2% (95% CI, 79.5–80.9%) in women with PCOS and 78.2% (95% CI, 77.9–78.5%) in those without PCOS. Adjusted FR was 0.81 (95% CI, 0.80–0.82) for first childbirth and 0.58 (95% CI, 0.57–0.60) for first childbirth following a spontaneous pregnancy. The FR for second childbirth was 0.79 (95% CI, 0.77–0.80). Women with PCOS had more than one child less frequently than the comparison group. Within the PCOS group, early age at diagnosis, later birth year, Nordic country of origin and low educational level positively influenced the FR. LIMITATIONS, REASONS FOR CAUTION Results are not adjusted for BMI, and time from intention to conceive to first childbirth could not be captured. Data on pregnancies, miscarriages or abortions and fertility treatment are unknown for women who did not give birth during the study period. Women with PCOS who did not seek medical assistance might have been incorrectly classified as not having the disease. Such misclassification would lead to an underestimation of the true association between PCOS and outcomes. WIDER IMPLICATIONS OF THE FINDINGS While cumulative probability of childbirth is similar between groups, women with PCOS need longer time to achieve their first childbirth. Women with PCOS have a lower FR and give birth to fewer children per woman than women without PCOS. Early diagnosis of and information about PCOS may improve affected women’s reproductive potential. STUDY FUNDING/COMPETING INTEREST(S) This study was funded by the Swedish Society of Medicine. Inger Sundström Poromaa has, over the past 3 years, received compensation as a consultant and lecturer for Bayer Schering Pharma, MSD, Gedeon Richter, Peptonics and Lundbeck A/S. The other authors declare no competing interests.

scholarly journals High Prevalence of the Polycystic Ovary Syndrome and Hirsutism in Women with Type 1 Diabetes Mellitus1

2000 ◽  
Vol 85 (11) ◽  
pp. 4182-4187 ◽  
Author(s):  
Héctor F. Escobar-Morreale ◽  
Belén Roldán ◽  
Raquel Barrio ◽  
Milagros Alonso ◽  
José Sancho ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Polycystic Ovary Syndrome ◽  
Type 1 Diabetes Mellitus ◽  
Polycystic Ovary ◽  
Normal Serum ◽  
Ovary Syndrome ◽  
Menstrual Dysfunction ◽  
High Prevalence

The current recommendation for strict metabolic control of type 1 diabetes mellitus requires the administration of supraphysiological doses of insulin, which might result in insulin-mediated stimulation of androgen synthesis, as occurs in insulin-resistant states. At present, the prevalence of hyperandrogenic disorders in women with type 1 diabetes mellitus is unknown. Eighty-five women with type 1 diabetes mellitus were evaluated for symptoms and signs of hyperandrogenism. In 68 of the patients, several serum androgen and hormone concentrations were measured. The polycystic ovary syndrome (PCOS) was defined by the presence of menstrual dysfunction, together with clinical and/or biochemical evidence of hyperandrogenism, and exclusion of other etiologies. Eighteen healthy women, menstruating regularly, served as controls for the androgenic profiles. Thirty-three patients (38.8%) presented hyperandrogenic disorders (16 had PCOS, and 17 had hirsutism without menstrual dysfunction). Type 1 diabetic patients with PCOS presented increased serum total and free testosterone concentrations, and serum androstenedione levels, but had normal serum sex hormone-binding globulin and dehydroepiandrosterone-sulfate levels. Hirsute type 1 diabetic women without menstrual dysfunction presented normal serum androgen levels. There were no significant differences between hyperandrogenic and nonhyperandrogenic type 1 diabetes mellitus women in clinical variables such as the duration of diabetes, age at diagnosis of diabetes, conventional or intensive insulin therapy, mean daily insulin dosage, or metabolic control. In conclusion, women with type 1 diabetes mellitus have a high prevalence of hyperandrogenic disorders, including PCOS and hirsutism.

scholarly journals Ovarian morphology and prevalence of polycystic ovary syndrome in Japanese women with type 1 diabetes mellitus

2013 ◽  
Vol 4 (3) ◽  
pp. 326-329 ◽  
Author(s):  
Arina Miyoshi ◽  
So Nagai ◽  
Masamitsu Takeda ◽  
Takuma Kondo ◽  
Hiroshi Nomoto ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Polycystic Ovary Syndrome ◽  
Type 1 Diabetes Mellitus ◽  
Polycystic Ovary ◽  
Japanese Women ◽  
Ovary Syndrome ◽  
Ovarian Morphology

scholarly journals A case of lean polycystic ovary syndrome with early stage of type 1 diabetes successfully treated with metformin [Rapid Communication]

2016 ◽  
Vol 63 (2) ◽  
pp. 193-198 ◽  
Author(s):  
Fumika Shigiyama ◽  
Naoki Kumashiro ◽  
Takayuki Rikitake ◽  
Shuki Usui ◽  
Michiko Saegusa ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Early Stage ◽  
Ovary Syndrome ◽  
Rapid Communication

scholarly journals Hypertension Risk in Young Women With Polycystic Ovary Syndrome: A Nationwide Population-Based Cohort Study

2020 ◽  
Vol 7 ◽  
Author(s):  
Cheng-Hsuan Wu ◽  
Lu-Ting Chiu ◽  
Yu-Jun Chang ◽  
Chun-I Lee ◽  
Maw-Sheng Lee ◽  
...  
Keyword(s):  
Cohort Study ◽  
Polycystic Ovary Syndrome ◽  
Young Women ◽  
Polycystic Ovary ◽  
Population Based ◽  
Ovary Syndrome ◽  
Hypertension Risk
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