Dietary macronutrient regulation of acyl and desacyl ghrelin concentrations in children with Prader‐Willi syndrome (PWS)

2020 ◽  
Vol 93 (5) ◽  
pp. 579-589
Author(s):  
Maha Alsaif ◽  
Mohammadreza Pakseresht ◽  
Michelle L. Mackenzie ◽  
Bruce Gaylinn ◽  
Michael O. Thorner ◽  
...  
Keyword(s):  
Prader Willi Syndrome ◽  
Desacyl Ghrelin

scholarly journals High Protein Meals Decrease the Ratio of Acyl and Desacyl Ghrelin to Peptide YY in Children with Prader‐Willi Syndrome

2015 ◽  
Vol 29 (S1) ◽  
Author(s):  
Sarah Loehr ◽  
Michelle MacKenzie ◽  
Bruce Gaylinn ◽  
Michael Thorner ◽  
Andrea Haqq
Keyword(s):  
Peptide Yy ◽  
High Protein ◽  
Prader Willi Syndrome ◽  
Desacyl Ghrelin

scholarly journals Long-acting octreotide treatment causes a sustained decrease in ghrelin concentrations but does not affect weight, behaviour and appetite in subjects with Prader–Willi syndrome

2008 ◽  
Vol 159 (4) ◽  
pp. 381-388 ◽  
Author(s):  
Kathleen De Waele ◽  
Stacey L Ishkanian ◽  
Roberto Bogarin ◽  
Charmaine A Miranda ◽  
Mohammad A Ghatei ◽  
...  
Keyword(s):  
Body Mass ◽  
Peptide Yy ◽  
Prader Willi Syndrome ◽  
Ghrelin Receptor ◽  
Desacyl Ghrelin ◽  
Compulsive Behaviour ◽  
Octreotide Treatment ◽  
Long Acting ◽  
Transient Elevation ◽  
Ghrelin Secretion

ObjectiveGhrelin is secreted primarily by the stomach and circulates as both acylated and desacyl ghrelin. Acylated (but not desacyl) ghrelin stimulates appetite. Both concentrations are elevated in Prader–Willi syndrome (PWS), suggesting that ghrelin may contribute to hyperphagia and overweight in these subjects. We evaluated whether long-acting octreotide (Oct) decreases acylated and desacyl ghrelin concentrations, body mass, appetite and compulsive behaviour towards food in adolescents with PWS.DesignA 56-week prospective, randomized, cross-over trial.MethodsNine subjects with PWS (age 14.6 (10.8–18.9) years, body mass index (BMI) Z-score +1.9 (0.6–3.0)) received either Oct (30 mg) or saline i.m. every 4 weeks for 16 weeks and were switched over to the other treatment after a 24-week washout period.ResultsEight subjects completed the study. Oct caused a decrease in both acylated (−53%) and desacyl (−54%) fasting ghrelin concentrations (P<0.05) but did not significantly affect BMI. Oct had no significant effect on peptide YY concentrations, appetite or compulsive behaviour towards food. Oct caused a decrease in insulin-like growth factor-I concentrations, an increase in HbA1c and transient elevation of blood glucose in two subjects. Three subjects developed gallstones.ConclusionsOct treatment caused a prolonged decrease in ghrelin concentrations in adolescents with PWS but did not improve body mass or appetite. Future intervention studies aiming at clarifying the role of ghrelin in PWS should focus on the administration of specific inhibitors of ghrelin secretion or ghrelin receptor activity that do not interfere with other appetite-regulating peptides.

Prader-willi syndrome: Genetics and behavior

1996 ◽  
Vol 71 (4) ◽  
pp. 187-212 ◽  
Author(s):  
Travis Thompson ◽  
Merlin Butler ◽  
William MacLean ◽  
Beth Joseph
Keyword(s):  
Prader Willi Syndrome ◽  
And Behavior

Profiles of obesity in Prader-Willi syndrome

2014 ◽  
Vol 122 (03) ◽  
Author(s):  
E Bogova ◽  
N Volevodz ◽  
V Peterkova
Keyword(s):  
Prader Willi Syndrome

Changing patterns of growth in children with prader-willi syndrome

2017 ◽  
Author(s):  
Georgia Irene Neophytou ◽  
Mikaela Frixou ◽  
M Guftar Shaikh ◽  
Andreas Kyriakou
Keyword(s):  
Prader Willi Syndrome ◽  
Changing Patterns
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