scholarly journals Three years of growth hormone treatment in young adults with Prader‐Willi Syndrome previously treated with growth hormone in childhood: Effects on glucose homeostasis and metabolic syndrome

2020 ◽  
Vol 93 (4) ◽  
pp. 439-448 ◽  
Author(s):  
Layla Damen ◽  
Lionne N. Grootjen ◽  
Stephany H. Donze ◽  
Alicia F. Juriaans ◽  
Laura C. G. Graaff ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Growth Hormone ◽  
Young Adults ◽  
Glucose Homeostasis ◽  
Growth Hormone Treatment ◽  
Hormone Treatment ◽  
Prader Willi Syndrome ◽  
Previously Treated

scholarly journals Effects of Childhood Multidisciplinary Care and Growth Hormone Treatment on Health Problems in Adults with Prader-Willi Syndrome

2021 ◽  
Vol 10 (15) ◽  
pp. 3250
Author(s):  
Karlijn Pellikaan ◽  
Anna G. W. Rosenberg ◽  
Kirsten Davidse ◽  
Anja A. Kattentidt-Mouravieva ◽  
Rogier Kersseboom ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Hormone Treatment ◽  
Multidisciplinary Care ◽  
Hormone Treatment ◽  
Health Problems ◽  
Pituitary Hormone ◽  
Childhood And Adolescence ◽  
Prader Willi Syndrome ◽  
Adult Age ◽  
Beneficial Effects

Prader-Willi syndrome (PWS) is a complex hypothalamic disorder. Features of PWS include hyperphagia, hypotonia, intellectual disability, and pituitary hormone deficiencies. The combination of growth hormone treatment and multidisciplinary care (GHMDc) has greatly improved the health of children with PWS. Little is known about the effects of childhood GHMDc on health outcomes in adulthood. We retrospectively collected clinical data of 109 adults with PWS. Thirty-nine had received GHMDc during childhood and adolescence (GHMDc+ group) and sixty-three had never received growth hormone treatment (GHt) nor multidisciplinary care (GHMDc− group). Our systematic screening revealed fewer undetected health problems in the GHMDc+ group (10%) than in the GHMDc− group (84%). All health problems revealed in the GHMDc+ group had developed between the last visit to the paediatric and the first visit to the adult clinic and/or did not require treatment. Mean BMI and the prevalence of diabetes mellitus type 2 were significantly lower in the GHMDc+ group compared to the GHMDc− group. As all patients who received GHt were treated in a multidisciplinary setting, it is unknown which effects are the result of GHt and which are the result of multidisciplinary care. However, our data clearly show that the combination of both has beneficial effects. Therefore, we recommend continuing GHMDc after patients with PWS have reached adult age.

scholarly journals Effects of growth hormone treatment in adults with Prader–Willi syndrome

2013 ◽  
Vol 23 (3) ◽  
pp. 81-87 ◽  
Author(s):  
M.G. Butler ◽  
B.K. Smith ◽  
J. Lee ◽  
C. Gibson ◽  
C. Schmoll ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Hormone Treatment ◽  
Hormone Treatment ◽  
Prader Willi Syndrome

scholarly journals Low dose growth hormone treatment in infants and toddlers with Prader-Willi syndrome is comparable to higher dosage regimens

2017 ◽  
Vol 34 ◽  
pp. 1-7 ◽  
Author(s):  
Elly Scheermeyer ◽  
Mark Harris ◽  
Ian Hughes ◽  
Patricia A. Crock ◽  
Geoffrey Ambler ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Low Dose ◽  
Growth Hormone Treatment ◽  
Hormone Treatment ◽  
Prader Willi Syndrome ◽  
Infants And Toddlers ◽  
Dosage Regimens
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