Weight gain after curative parathyroidectomy predicts increase in bone mineral density in patients with symptomatic primary hyperparathyroidism

2020 ◽  
Vol 93 (1) ◽  
pp. 28-35 ◽  
Author(s):  
Rimesh Pal ◽  
Ashutosh K. Arya ◽  
Anshita Aggarwal ◽  
Priyanka Singh ◽  
Divya Dahiya ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Weight Gain ◽  
Primary Hyperparathyroidism ◽  
Bone Mineral ◽  
Mineral Density

scholarly journals P114 Effect of vitamin D on parathyroid hormone, serum calcium and bone mineral density in patients with primary hyperparathyroidism being managed conservatively

Rheumatology ◽  
2021 ◽  
Vol 60 (Supplement_1) ◽  
Author(s):  
Mahrukh Khalid ◽  
Vismay Deshani ◽  
Khalid Jadoon
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Parathyroid Hormone ◽  
Primary Hyperparathyroidism ◽  
Bone Mineral ◽  
Serum Calcium ◽  
Mineral Density ◽  
Neck Of Femur ◽  
Vitamin D Levels ◽  
Significant Difference

Abstract Background/Aims  Vitamin D deficiency is associated with more severe presentation of primary hyperparathyroidism (PTHP) with high parathyroid hormone (PTH) levels and reduced bone mineral density (BMD). We analyzed data to determine if vitamin D levels had any impact on PTH, serum calcium and BMD at diagnosis and 3 years, in patients being managed conservatively. Methods  Retrospective analysis of patients presenting with PHPT. Based on vitamin D level at diagnosis, patients were divided into two groups; vitamin D sufficient (≥ 50 nmol/L) and vitamin D insufficient (≤ 50 nmol/L). The two groups were compared for age, serum calcium and PTH levels at diagnosis and after mean follow up of 3 years. BMD at forearm and neck of femur (NOF) was only analyzed in the two groups at diagnosis, due to lack of 3 year’s data. Results  There were a total of 93 patients, 17 males, mean age 70; range 38-90. Mean vitamin D level was 73.39 nmol/L in sufficient group (n = 42) and 34.48 nmol/L in insufficient group (n = 40), (difference between means -38.91, 95% confidence interval -45.49 to -32.33, p < 0.0001). There was no significant difference in age, serum calcium and PTH at the time of diagnosis. After three years, there was no significant difference in vitamin D levels between the two groups (mean vitamin D 72.17 nmol/L in sufficient group and 61.48 nmol/L in insufficient group). Despite rise in vitamin D level in insufficient group, no significant change was observed in this group in PTH and serum calcium levels. BMD was lower at both sites in vitamin D sufficient group and difference was statistically significant at NOF. Data were analyzed using unpaired t test and presented as mean ± SEM. Conclusion  50% of patients presenting with PHPT were vitamin D insufficient at diagnosis. Vitamin D was adequately replaced so that at 3 years there was no significant difference in vitamin D status in the two groups. Serum calcium and PTH were no different in the two groups at diagnosis and at three years, despite rise in vitamin D levels in the insufficient group. Interestingly, BMD was lower at forearm and neck of femur in those with sufficient vitamin D levels and the difference was statistically significant at neck of femur. Our data show that vitamin D insufficiency does not have any significant impact on PTH and calcium levels and that vitamin D replacement is safe in PHPT and does not impact serum calcium and PTH levels in the short term. Lower BMD in those with adequate vitamin D levels is difficult to explain and needs further research. Disclosure  M. Khalid: None. V. Deshani: None. K. Jadoon: None.

Insulin Sensitivity and Bone Mineral Density in Primary Hyperparathyroidism

2011 ◽  
pp. P1-238-P1-238
Author(s):  
Francesco Tassone ◽  
Laura Gianotti ◽  
Flora Cesario ◽  
Claudia Baffoni ◽  
Micaela Pellegrino ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Insulin Sensitivity ◽  
Primary Hyperparathyroidism ◽  
Bone Mineral ◽  
Mineral Density

Analysis of the Increase in Bone Mineral Density After Surgical Treatment of Primary Hyperparathyroidism

2019 ◽  
Vol 22 (2) ◽  
pp. 171-178 ◽  
Author(s):  
Fernando Mendoza-Moreno ◽  
Manuel Díez-Alonso ◽  
Enrique Ovejero-Merino ◽  
Ana Sánchez-Gollarte ◽  
Ricardo Alvarado-Hurtado ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Surgical Treatment ◽  
Primary Hyperparathyroidism ◽  
Bone Mineral ◽  
Mineral Density

scholarly journals Bone mineral density evolution after parathyroidectomy in patients with primary hyperparathyroidism

2015 ◽  
Author(s):  
Alicia Vicuna ◽  
Ana Ramos-Levi ◽  
Miguel Sampedro-Nunez ◽  
Sandra Campos ◽  
Magaly Zelada ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Primary Hyperparathyroidism ◽  
Bone Mineral ◽  
Mineral Density ◽  
Density Evolution

scholarly journals Bone Mineral Density Accrual Determines Energy Expenditure with Refeeding in Anorexia Nervosa and Supersedes Return of Menses

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Melissa Sum ◽  
Laurel Mayer ◽  
Michelle P. Warren
Keyword(s):  
Bone Mineral Density ◽  
Anorexia Nervosa ◽  
Weight Gain ◽  
Energy Expenditure ◽  
Bone Formation ◽  
Bone Mineral ◽  
Subgroup Analysis ◽  
Resting Energy Expenditure ◽  
Nutritional Rehabilitation ◽  
Mineral Density

Osteopenia and osteoporosis are major complications of anorexia nervosa (AN). Since bone is a tissue requiring large amounts of energy, we examined the disproportionate increase in resting energy expenditure (REE) that occurs with refeeding of AN patients to determine if it was related to bone accretion. Thirty-seven AN patients aged23.4±4.8years underwent a behavioral weight-gain protocol lasting a median of 66 days; 27 remained amenorrheic, and 10 regained menses. Sixteen controls aged25.1±4.7years were age- and % IBW matched with patients. REE was measured using a respiratory chamber-indirect calorimeter. Significant correlations were found between REE and changes in spine (r=0.48,P<0.02) and leg (r=0.43,P<0.05) BMDs in AN patients. Further subgroup analysis of the amenorrheics revealed significant correlation between REE and change in spine BMD (r=0.59,P<0.02) and higher IGF-1 after weight gain compared to controls. Amenorrheics also had lower BMDs. These findings were absent in the regained menses group. The increase in REE seen in women with AN during nutritional rehabilitation may be related to active bone formation, which is not as prominent when menses have returned.

scholarly journals Erratum to: Predictors of Bone Mineral Density Improvement in Patients Undergoing Parathyroidectomy for Primary Hyperparathyroidism

2014 ◽  
Vol 38 (10) ◽  
pp. 2740-2740
Author(s):  
Jyotirmay Sharma ◽  
Dina S. Itum ◽  
Lewis Moss ◽  
C. Li ◽  
Collin Weber
Keyword(s):  
Bone Mineral Density ◽  
Primary Hyperparathyroidism ◽  
Bone Mineral ◽  
Mineral Density

Recovery of Bone Mineral Density in 126 Patients after Surgery for Primary Hyperparathyroidism

2004 ◽  
Vol 28 (5) ◽  
pp. 502-507 ◽  
Author(s):  
Erik Nordenstr�m ◽  
Johan Westerdahl ◽  
Anders Bergenfelz
Keyword(s):  
Bone Mineral Density ◽  
Primary Hyperparathyroidism ◽  
Bone Mineral ◽  
Mineral Density
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