scholarly journals Impact of ultrasonographic features, cytomorphology and mutational testing on malignant and indeterminate thyroid nodules on diagnostic accuracy of fine needle cytology samples: A prospective analysis of 141 patients

2019 ◽  
Vol 91 (6) ◽  
pp. 851-859 ◽  
Author(s):  
Franco Fulciniti ◽  
Anna Cipolletta Campanile ◽  
Maria Gabriella Malzone ◽  
Maria Grazia Chiofalo ◽  
Anna Capiluongo ◽  
...  
Keyword(s):  
Diagnostic Accuracy ◽  
Thyroid Nodules ◽  
Prospective Analysis ◽  
Fine Needle ◽  
Fine Needle Cytology

Fine-needle cytology of solid tumors: Method, diagnostic accuracy, and role in management

1990 ◽  
Vol 25 (10) ◽  
pp. 1088-1091 ◽  
Author(s):  
A.J.W. Millar ◽  
C. Sinclair-Smith ◽  
H. Rode ◽  
P. Hartley ◽  
C. Karabus ◽  
...  
Keyword(s):  
Diagnostic Accuracy ◽  
Solid Tumors ◽  
Fine Needle ◽  
Fine Needle Cytology

scholarly journals Assessment of perinodular stiffness in differentiating malignant from benign thyroid nodules

2021 ◽  
Author(s):  
Lei Hu ◽  
Xiao Liu ◽  
Chong Pei ◽  
Li Xie ◽  
Nianan He
Keyword(s):  
Risk Stratification ◽  
Diagnostic Accuracy ◽  
Thyroid Nodules ◽  
Needle Aspiration ◽  
Fine Needle ◽  
Measurement Function ◽  
Conventional Ultrasound ◽  
Single Method ◽  
Benign Thyroid Nodules ◽  
Benign Thyroid

Objective: We evaluated the diagnostic accuracy of perinodular stiffness, four risk stratification systems (RSSs) (KWAK-TIRADS, ACR-TIRADS, EU-TIRADS, and C-TIRADS), and the combination of perinodular stiffness and these four RSSs in differentiating malignant from benign thyroid nodules (TNs). Methods: A total of 788 TNs in 726 patients were examined with conventional ultrasound (US) examination and sound touch elastography (STE). All TNs were classified by each of the four RSSs. The stiffness inside (E) the TNs was measured by STE. The stiffness of the 2.0mm perinodular region (Eshell) was measured with the Shell measurement function of STE. The diagnostic performances of four RSSs, the E values, and the Eshell values were evaluated. All TNs were further divided into subgroups based on size (≤ 10 mm group and > 10 mm group). Results: Ninety-six TNs were classified as benign and 692 as malignant. Among the single-method approaches, ACR-TIRADS showed the highest AUC (0.77) for differentiating malignant from benign TNs for all TNs included. Eshell showed the highest AUC (0.75) in differentiating malignant from benign TNs for TNs with sizes ≤ 10 mm, and there were no significant differences in AUC among all single methods for diagnosis of TNs with sizes > 10 mm (P > 0.05). The combination of C-TIRADS and Eshell/E yielded the highest AUC for all TNs (0.83) and for TNs with size ≤ 10 mm (0.85) compared with other combinations. Conclusions: Eshell/E combined with conventional US improves the diagnostic accuracy in TNs, and may reduce unnecessary fine needle aspiration.

Diagnostic Accuracy of Fine Needle Aspiration in Thyroid Nodules Greater Than or Equal to 3cm: Comparative Study

2015 ◽  
Vol 4 (6) ◽  
pp. S74-S75
Author(s):  
Rohini Kannuswamy ◽  
George Georges ◽  
Suh Won Lee ◽  
Mariana Garcia Touza ◽  
Magda Esebua
Keyword(s):  
Comparative Study ◽  
Diagnostic Accuracy ◽  
Fine Needle Aspiration ◽  
Thyroid Nodules ◽  
Needle Aspiration ◽  
Fine Needle

scholarly journals Cytology Versus Calcitonin Assay in Fine-needle Aspiration Biopsy Wash-out Fluid (FNAB-CT) in Diagnosis of Medullary Thyroid Microcarcinoma.

2021 ◽  
Author(s):  
Ziyuan Liu ◽  
Wenzhong Zhou ◽  
Rulai Han ◽  
Wei Zhou ◽  
Jie Zhang ◽  
...  
Keyword(s):  
Diagnostic Accuracy ◽  
Fine Needle Aspiration ◽  
Thyroid Nodules ◽  
Fine Needle Aspiration Biopsy ◽  
Elevated Serum ◽  
Needle Aspiration ◽  
Aspiration Biopsy ◽  
Serum Calcitonin ◽  
Fine Needle ◽  
Needle Aspiration Biopsy

Abstract Purpose Widespread use of sensitive ultrasound examination led to an increasing detection of medullary thyroid microcarcinoma (micro-MTC). This prospective study evaluated the diagnostic accuracy of Fine-needle Aspiration Biopsy Cytology (FNAB-C) and calcitonin assay in Fine-needle Aspiration Biopsy wash-out fluid (FNAB-CT) in thyroid nodules less than 1cm with elevated serum calcitonin. Methods 87 thyroid nodules from 60 patients with elevated serum calcitonin(＞10pg/ml) were included and 51 were thyroid nodules less than 1cm. FNAB-CT and FNAB-C was performed to distinguish MTC lesions before surgery, histopathologic diagnoses served as main reference standards.Results FNAB-CT had a greater performance over FNAB-C for preoperative diagnosis of MTC (diagnostic accuracy: 98.85％vs 61.90％, sensitivity: 98.55％ vs 55.07％, specificity: 100％ vs 97.44％), especially for micro-MTC: FNAB-C established a sensitivity and diagnostic accuracy of 48.78％ and 58％ respectively, while FNAB-CT reached 97.56% sensitivity and 98.04% diagnostic accuracy. Conclusions FNAB-CT demonstrated high diagnostic accuracy in diagnosing micro-MTC. Patients with micro thyroid nodules and elevated sCT level should perform FNAB-CT to exclude the diagnosis of MTC lesions.

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