Improved menstrual function in obese women with polycystic ovary syndrome after behavioural modification intervention-A randomized controlled trial

2019 ◽  
Vol 90 (3) ◽  
pp. 468-478 ◽  
Author(s):  
Emma Oberg ◽  
Sebastian Gidlöf ◽  
Ivika Jakson ◽  
Marja Mitsell ◽  
Petra Tollet Egnell ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Controlled Trial ◽  
Obese Women ◽  
Ovary Syndrome ◽  
Menstrual Function ◽  
Randomized Controlled ◽  
Behavioural Modification ◽  
Modification Intervention

scholarly journals Comparative Effectiveness of Aerobic Exercise Versus Yi Jin Jing On Reproductive Health In Young Overweight/Obese Women With Polycystic Ovary Syndrome: Study Protocol For A Randomized Controlled Trial.

2021 ◽  
Author(s):  
Jing Zhao ◽  
Antonnette Ketlhoafetse ◽  
Xiangyun Liu ◽  
Yang Cao
Keyword(s):  
Randomized Controlled Trial ◽  
Polycystic Ovary Syndrome ◽  
Aerobic Exercise ◽  
Comparative Effectiveness ◽  
Polycystic Ovary ◽  
Controlled Trial ◽  
Obese Women ◽  
Ovary Syndrome ◽  
Randomized Controlled ◽  
Yi Jin Jing

Abstract Background: Polycystic ovary syndrome (PCOS) is the most common heterogeneous endocrine disease among women of childbearing age, affecting women throughout life on their reproductive, metabolic and cardiovascular health, as well as psychological health. Aerobic exercise is an important solution used to manage PCOS, due to its multiple benefits. Yi Jin Jing is an important component of traditional Chinese exercise (TCE), based on the root of traditional Chinese medicine theory (TCM), which focuses on keeping the body as a whole in a harmonious state. However, to date there is no literature on the benign effects of Yi Jin Jing on PCOS. The primary purpose of this protocol is to assess the effectiveness of aerobic exercise versus Yi Jin Jing, on the management of PCOS-related reproductive health in young overweight/obese women.Methods: The study will conduct a three-armed parallel-group of a randomized controlled trial, recruiting 90 women diagnosed with PCOS, ages between 18 and 35 years, with a body mass index (BMI) ≥ 23 kg/m2. Women will be randomly assigned to either control group (combined oral contraceptives) or one of the intervention groups (Yi Jin Jing group or aerobic exercise group) with an allocation rate of 1:1:1. The intervention will be conducted within a 12-week period. The primary outcomes would be anti-Mullerian hormone (AMH) level and menstrual frequency; the secondary outcomes would be biochemical profiles, ovarian volume, antral follicle count, BMI and homeostasis model assessment of insulin resistance (HOMA-IR). Outcome measures would be collected during baseline and end of treatment. Reporting of the study will follow the Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) statement.Discussion: This proposed study will be the first randomized clinical trial to evaluate the comparative effectiveness of aerobic exercise versus Yi Jin Jing on the management of PCOS-related reproductive symptoms in young overweight/obese women. The results will provide a new evidence-based management strategy for young women with PCOS. Trial registration: Chinese Clinical Trail Registry, ID: ChiCTR1900022385. Registered on 9 April 2019, http://www.chictr.org.cn/listbycreater.aspx.

scholarly journals Acupuncture and Clomiphene Citrate for Live Birth in Polycystic Ovary Syndrome: Study Design of a Randomized Controlled Trial

2013 ◽  
Vol 2013 ◽  
pp. 1-11 ◽  
Author(s):  
Hongying Kuang ◽  
Yan Li ◽  
Xiaoke Wu ◽  
Lihui Hou ◽  
Taixiang Wu ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Polycystic Ovary Syndrome ◽  
Live Birth ◽  
Polycystic Ovary ◽  
Controlled Trial ◽  
Clomiphene Citrate ◽  
Fertility Treatment ◽  
Ovary Syndrome ◽  
Randomized Controlled ◽  
Multicenter Randomized Controlled Trial

Acupuncture is an alternative therapy to induce ovulation in women with polycystic ovary syndrome (PCOS), but there is no study reporting the live birth rate following ovulation induction by acupuncture or its potential as an adjuvant treatment to clomiphene citrate (CC). We assess the efficacy of acupuncture with or without CC in achieving live births among 1000 PCOS women in Mainland China. This paper reports the methodology of an ongoing multicenter randomized controlled trial. The randomization scheme is coordinated through the central mechanism and stratified by the participating sites. Participants will be randomized into one of the four treatment arms: (A) true acupuncture and CC, (B) control acupuncture and CC, (C) true acupuncture and placebo CC, and (D) control acupuncture and placebo CC. To ensure the quality and integrity of the trial we have developed a unique multinational team of investigators and Data and Safety Monitoring Board. Up to the end of April 2013, 326 subjects were recruited. In conclusion, the success of this trial will allow us to evaluate the additional benefit of acupuncture beyond the first line medicine for fertility treatment in PCOS women in an unbiased manner.

Sign in / Sign up

Export Citation Format

Share Document