scholarly journals Immunosuppressive therapy of autoimmune hypoparathyroidism in a patient with activating autoantibodies against the calcium-sensing receptor

2018 ◽  
Vol 90 (1) ◽  
pp. 214-221 ◽  
Author(s):  
Mina Chamberlin ◽  
E. Helen Kemp ◽  
Anthony P. Weetman ◽  
Bhupesh Khadka ◽  
Edward M. Brown
Keyword(s):  
Immunosuppressive Therapy ◽  
Calcium Sensing Receptor ◽  
Calcium Sensing ◽  
Activating Autoantibodies

scholarly journals Activating Autoantibodies against the Calcium-Sensing Receptor Detected in Two Patients with Autoimmune Polyendocrine Syndrome Type 1

2009 ◽  
Vol 94 (12) ◽  
pp. 4749-4756 ◽  
Author(s):  
E. Helen Kemp ◽  
Nikos G. Gavalas ◽  
Kai J. E. Krohn ◽  
Edward M. Brown ◽  
Philip F. Watson ◽  
...  
Keyword(s):  
Inositol Phosphate ◽  
Autosomal Recessive Disorder ◽  
Syndrome Type ◽  
Calcium Sensing Receptor ◽  
Autoimmune Reaction ◽  
Aire Gene ◽  
Calcium Sensing ◽  
Autoimmune Polyendocrine Syndrome ◽  
Activating Autoantibodies

Context: Autoimmune polyendocrine syndrome type 1 (APS1) is an autosomal recessive disorder caused by mutations in the autoimmune regulator (AIRE) gene. Hypoparathyroidism occurs in 80% of patients with APS1 and has been suggested to result from an autoimmune reaction against the calcium-sensing receptor (CaSR) in parathyroid cells. Anti-CaSR binding antibodies have previously been detected in patients with APS1. Objective: The aim of this study was to determine whether anti-CaSR antibodies present in APS1 patients could modulate the response of the CaSR to stimulation by Ca2+. Results: The results indicated that two of the 14 APS1 patients included in the study had anti-CaSR antibodies that stimulated the receptor. These antibodies were detected by their ability to increase both Ca2+-dependent extracellular signal-regulated kinase phosphorylation and inositol phosphate accumulation in human embryonic kidney 293 cells expressing the CaSR. Conclusion: An important implication of the present results is that although the majority of APS1 patients do not have CaSR-stimulating antibodies, there may be a small but substantial minority of patients in whom the hypoparathyroid state is the result of functional suppression of the parathyroid glands rather than their irreversible destruction.

Abstract #543 Teriparatide-Induced Hypercalcemic Crisis in a Patient on Lithium: Overwhelming the Calcium Sensing Receptor

2018 ◽  
Vol 24 ◽  
pp. 130-131
Author(s):  
Pratibha Abraham ◽  
Muhammad Siddiqui ◽  
Deepashree Gupta ◽  
Stewart Albert
Keyword(s):  
Calcium Sensing Receptor ◽  
Hypercalcemic Crisis ◽  
Calcium Sensing
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