Association between thyroid hormone levels, body composition and insulin resistance in euthyroid subjects with normal thyroid ultrasound: The Kangbuk Samsung Health Study

2018 ◽  
Vol 89 (5) ◽  
pp. 649-655 ◽  
Author(s):  
Hyemi Kwon ◽  
Jung-Hwan Cho ◽  
Da Young Lee ◽  
Se Eun Park ◽  
Cheol-Young Park ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Body Composition ◽  
Thyroid Hormone ◽  
Health Study ◽  
Thyroid Ultrasound ◽  
Normal Thyroid ◽  
Hormone Levels ◽  
Thyroid Hormone Levels

scholarly journals Correlation Between the Thyroid Hormone Levels and Nonalcoholic Fatty Liver Disease in Type 2 Diabetic Patients with Normal Thyroid Function

2020 ◽  
Author(s):  
Yuanyuan Zhang ◽  
Huaizhen Liu ◽  
Juyi Li ◽  
Ling Li ◽  
Jinjun Zhang ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Liver Fibrosis ◽  
Thyroid Function ◽  
Fatty Liver Disease ◽  
Nonalcoholic Fatty Liver ◽  
Normal Thyroid ◽  
Hormone Levels ◽  
Normal Thyroid Function ◽  
Thyroid Hormone Levels

Abstract Background: The objective of this study is to retrospectively analyze the correlation between the thyroid hormones and nonalcoholic fatty liver disease (NAFLD) in type 2 diabetes mellitus (T2DM) patients with normal thyroid function. Methods: Totally 586 T2DM patients with normal thyroid function participated in this research and were divided into T2DM without NAFLD (240 cases) group and T2DM with NAFLD (346 cases) group. The NAFLD fibrosis score (NFS) >0.676 was defined as progressive liver fibrosis and used to categorize the patients into T2DM without progressive liver fibrosis group (493 cases) and T2DM with progressive liver fibrosis group (93 cases). Results: The results indicated that the levels of free triiodothyronine (FT3) and total triiodomethylamine (TT3) were significantly higher while the free thyroxine (FT4) level was lower in T2DM with NAFLD group than that in T2DM2 without NAFLD group (p<0.05). The levels of FT3, FT4 and TT3 in patients with progressive liver fibrosis were significantly lower in patients with progressive liver fibrosis than that in patients without progressive liver fibrosis (p<0.05). Logistic regression analysis showed a negative relationship between FT4 level and NAFLD (p=0.026), between the levels of FT4,TT3 and total thyroxine (TT4) and the risk of progressive hepatic fibrosis (p=0.022, p=0.007,p=0.046).Conclusion: There is a certain correlation between thyroid hormone levels and NAFLD in T2DM patients, suggesting that the assessment of thyroid hormone levels in T2DM patients with normal thyroid function is of great significance in the prevention and treatment of NAFLD.

Hyperthyrotropinemia in a Neonate with Normal Thyroid Hormone Levels: The Earliest Diagnostic Clue for Pseudohypoparathyroidism

Neonatology ◽  
1990 ◽  
Vol 58 (2) ◽  
pp. 69-72 ◽  
Author(s):  
Seitaro Yokoro ◽  
Mineko Matsuo ◽  
Takako Ohtsuka ◽  
Takehiko Ohzeki
Keyword(s):  
Thyroid Hormone ◽  
Normal Thyroid ◽  
Hormone Levels ◽  
Thyroid Hormone Levels ◽  
Diagnostic Clue

Prolactin insufficiency but normal thyroid hormone levels after cranial radiotherapy in long-term survivors of childhood leukaemia

2013 ◽  
Vol 79 (1) ◽  
pp. 71-78 ◽  
Author(s):  
Cecilia Follin ◽  
Katarina Link ◽  
Thomas Wiebe ◽  
Christian Moëll ◽  
Jonas Björk ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Childhood Leukaemia ◽  
Cranial Radiotherapy ◽  
Normal Thyroid ◽  
Hormone Levels ◽  
Thyroid Hormone Levels ◽  
Long Term Survivors

scholarly journals Serum Dioxin Concentrations and Thyroid Hormone Levels in the Seveso Women's Health Study

2014 ◽  
Vol 180 (5) ◽  
pp. 490-498 ◽  
Author(s):  
Jonathan Chevrier ◽  
Marcella Warner ◽  
Robert B. Gunier ◽  
Paolo Brambilla ◽  
Brenda Eskenazi ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Women’S Health ◽  
Women's Health ◽  
Health Study ◽  
Hormone Levels ◽  
Thyroid Hormone Levels

scholarly journals Insulin resistance and normal thyroid hormone levels: prospective study and metabolomic analysis

2017 ◽  
Vol 312 (5) ◽  
pp. E429-E436 ◽  
Author(s):  
Ele Ferrannini ◽  
Giorgio Iervasi ◽  
Jeff Cobb ◽  
Rudina Ndreu ◽  
Monica Nannipieri
Keyword(s):  
Oxidative Stress ◽  
Insulin Resistance ◽  
Insulin Sensitivity ◽  
Thyroid Hormone ◽  
Glucose Disposal ◽  
Β Cell ◽  
Hormone Levels ◽  
Glucose Sensitivity ◽  
Thyroid Hormone Levels ◽  
Cell Glucose

While hyperthyroidism and hypothyroidism cause dysglycemia, the relationship between thyroid hormone levels within the normal range and insulin resistance (IR) is unclear. In 940 participants with strictly normal serum concentrations of free triiodothyronine (fT3), free thyroxine (fT4), and thyroid-stimulating hormone (TSH) followed up for 3 yr, we measured insulin sensitivity (by the insulin clamp technique) and 35 circulating metabolites. At baseline, across quartiles of increasing fT3 levels (or fT3/fT4 ratio) most features of IR emerged [i.e., male sex, greater body mass index (BMI), waist circumference, heart rate, blood pressure, fatty liver index, free fatty acids, and triglycerides; reduced insulin-mediated glucose disposal; and β-cell glucose sensitivity). In multiadjusted analyses, fT3 was reciprocally related to insulin sensitivity and, in a subset of 303 subjects, directly related to endogenous glucose production. In multiple regression models adjusting for sex, age, BMI, and baseline value of insulin sensitivity, higher baseline fT3 levels were significant predictors of decreases in insulin sensitivity. Moreover, baseline fT3 predicted follow-up increases in glycemia independently of sex, age, BMI, insulin sensitivity, β-cell glucose sensitivity, and baseline glycemia. Serum tyrosine levels were higher with IR and were directly associated with fT3; higher α-hydroxybutyrate levels signaled enhanced oxidative stress, thereby impairing tyrosine degradation. In 25 patients with morbid obesity, surgery-induced weight loss improved IR and consensually lowered fT3 levels. High-normal fT3 levels are associated with IR both cross-sectionally and longitudinally, and predict deterioration of glucose tolerance. This association is supported by a metabolite pattern that points at increased oxidative stress as part of the IR syndrome.

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