Weight loss in obese girls with polycystic ovarian syndrome is associated with a decrease in Anti-Muellerian Hormone concentrations

2017 ◽  
Vol 87 (2) ◽  
pp. 185-193 ◽  
Author(s):  
Thomas Reinehr ◽  
Alexandra Kulle ◽  
Juliane Rothermel ◽  
Caroline Knop ◽  
Nina Lass ◽  
...  
Keyword(s):  
Weight Loss ◽  
Polycystic Ovarian Syndrome ◽  
Ovarian Syndrome

Sleeve Gastrectomy for Obesity in Polycystic Ovarian Syndrome: Weight Loss and Fertility Outcomes

2017 ◽  
Vol 13 (10) ◽  
pp. S15 ◽  
Author(s):  
Joshua Dilday ◽  
Michael Derickson ◽  
John Kuckelman ◽  
Julia Bader ◽  
Eric Ahnfeldt ◽  
...  
Keyword(s):  
Weight Loss ◽  
Sleeve Gastrectomy ◽  
Polycystic Ovarian Syndrome ◽  
Ovarian Syndrome

scholarly journals Longitudinal analyses of the steroid metabolome in obese PCOS girls with weight loss

2017 ◽  
Vol 6 (4) ◽  
pp. 213-224 ◽  
Author(s):  
Thomas Reinehr ◽  
Alexandra Kulle ◽  
Juliane Rothermel ◽  
Caroline Knop-Schmenn ◽  
Nina Lass ◽  
...  
Keyword(s):  
Weight Loss ◽  
Steroid Hormones ◽  
Weight Status ◽  
Polycystic Ovarian Syndrome ◽  
Longitudinal Analyses ◽  
Steroid Profiling ◽  
Underlying Mechanisms ◽  
17 Hydroxyprogesterone ◽  
One Year ◽  
Ovarian Syndrome

Objective The underlying mechanisms of polycystic ovarian syndrome (PCOS) are not fully understood yet. The aim of the study was to get functional insights into the regulation of steroid hormones in PCOS by steroid metabolomics. Design This is a longitudinal study of changes of steroid hormones in 40 obese girls aged 13–16 years (50% with PCOS) participating in a 1-year lifestyle intervention. Girls with and without PCOS were matched to age, BMI and change of weight status. Methods We measured progesterone, 17-hydroxyprogesterone, 17-hydroxyprogenolon, 11-deoxycorticosterone, 21-deoxycorticosterone, deoxycorticosterone, corticosterone, 11-deoxycortisol, cortisol, cortisone, androstenedione, testosterone, dehydroepiandrostendione-sulfate (DHEA-S), estrone and estradiol by LC–MS/MS steroid profiling at baseline and one year later. Results At baseline, obese PCOS girls demonstrated significantly higher androstenedione and testosterone concentrations compared to obese girls without PCOS, whereas the other steroid hormones including glucocorticoids, mineralocorticoids, estrogens and precursors of androgens did not differ significantly. Weight loss in obese PCOS girls was associated with a significant decrease of testosterone, androstenedione, DHEA-S, cortisol and corticosterone concentrations. Weight loss in obese non-PCOS girls was associated with a significant decrease of DHEA-S, cortisol and corticosterone concentrations, whereas no significant changes of testosterone and androstenedione concentrations could be observed. Without weight loss, no significant changes of steroid hormones were measured except an increase of estradiol in obese PCOS girls without weight loss. Conclusions The key steroid hormones in obese adolescents with PCOS are androstenedione and testosterone, whereas glucocorticoids, mineralocorticoids, estrogens and precursors of androgens did not differ between obese girls with and without PCOS.

scholarly journals Effect of Exercise and Weight Loss in Polycystic Ovarian Syndrome among Obese Women

2021 ◽  
Vol 29 (S1) ◽  
Author(s):  
Thomas Cochrane ◽  
Tengku Fadilah Tengku-Kamalden ◽  
Rachel Davey ◽  
Roxana Dev Omar Dev
Keyword(s):  
Heart Rate ◽  
Weight Loss ◽  
Body Weight ◽  
Polycystic Ovarian Syndrome ◽  
Intervention Group ◽  
Small Sample ◽  
Lean Body Weight ◽  
Obese Women ◽  
Fat Percentage ◽  
Ovarian Syndrome

Ovulation and fertility can be improved by weight loss in obese women with Polycystic Ovarian Syndrome (PCOS). The aim of this study was to investigate the effectiveness of a twelve-week supervised exercise program in combination with dietary restrictions for obese women with PCOS. The study is a quasi-experimental research and used an experimental pre- and post-test design. Fifteen women recruited from Fertility Clinic, Jessops Hospital for Women, Sheffield took part in this study. Respiratory exchange ratio (RER), heart rate, perceived exertion (RPE), and Houston non-exercise activity code were recorded. Height, weight, and body girth measurements were taken to calculate body mass index, fat percentage, and lean body weight. The intervention group lost an average of 3.1 kg and gained 3.45 kg of lean body weight. Loss of fat percentage was 12.1%. No significant difference was found in the control group. The RER and heart rate value decreased for the same workload in the intervention group, indicating higher tolerance towards exercise intensity. However, the changes for both groups were not significant. The average group compliance rate was 53% (at least two sessions per week). Bearing in mind the small sample size (n=4) for control, the improvement in fitness, significant weight loss, and body composition change (increase in fat-free mass) was achieved in this study. Twelve weeks of exercise, combined with dietary advice, were sufficient to benefit PCOS obese women. The research has achieved a commendable weight-loss objective and has demonstrated increases in standards of fitness among obese women.

scholarly journals The Effect of Vertical Sleeve Gastrectomy on a Rat Model of Polycystic Ovarian Syndrome

Endocrinology ◽  
2011 ◽  
Vol 152 (10) ◽  
pp. 3700-3705 ◽  
Author(s):  
Hilary E. Wilson-Pérez ◽  
Randy J. Seeley
Keyword(s):  
Bariatric Surgery ◽  
Weight Loss ◽  
Body Weight ◽  
Glucose Tolerance ◽  
Polycystic Ovarian Syndrome ◽  
Vertical Sleeve Gastrectomy ◽  
Metabolic Disturbances ◽  
Menstrual Dysfunction ◽  
Estrous Cyclicity ◽  
Ovarian Syndrome

Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder of women of reproductive age. Although some of the primary symptoms of PCOS are reproductive abnormalities, including hyperandrogenism, menstrual dysfunction, and hirsutism, other metabolic disturbances are also common, including obesity and insulin resistance. Women with PCOS who have undergone weight-loss bariatric surgery have reported surprising postoperative benefits beyond weight loss, including resolution of menstrual dysfunction and improvement of hirsutism. Here, we use a chronic dihydrotestosterone (DHT) exposure model of PCOS in female rats and investigate the efficacy of a specific type of bariatric surgery, namely vertical sleeve gastrectomy (VSG), to resolve the reproductive and metabolic disturbances induced by DHT treatment. We find that VSG causes loss of body weight and body fat in DHT-treated rats but does not improve glucose tolerance or restore estrous cyclicity. Although human PCOS patients have shown decreased androgen levels after bariatric surgery, the chronic nature of DHT administration in this rat model both before and after VSG renders this effect impossible in this case. Therefore, the lack of improvement in glucose tolerance and estrous cyclicity may implicate a direct effect of androgen knockdown as a mechanism for the improvements seen in human PCOS patients after bariatric surgery. In addition, the dissociation of body weight loss without improved glucose tolerance suggests that glucose intolerance may be a body weight-independent phenomenon in women with PCOS.

scholarly journals EFFECTIVENESS OF LIFESTYLE MODIFICATION ON WEIGHTLOSS AND QUALITY OF LIFE IN OBESE WOMEN WITH POLYCYSTIC OVARIAN SYNDROME

2018 ◽  
Vol 11 (9) ◽  
pp. 333
Author(s):  
Vinaya Rajendra Patil ◽  
Poovishnu Devi Thangavelu ◽  
Vaishali Krishnat Jagtap
Keyword(s):  
Quality Of Life ◽  
Weight Loss ◽  
Polycystic Ovarian Syndrome ◽  
Lifestyle Modification ◽  
Obese Women ◽  
Group A ◽  
Conventional Physiotherapy ◽  
Group B ◽  
Ovarian Syndrome

Objectives: (1) The objectives of this study were to determine the effectiveness of lifestyle modification on weight loss and the quality of life in obese women with the polycystic ovarian syndrome and (2) to determine the effectiveness of conventional physiotherapy on weight loss and the quality of life in obese women with polycystic ovarian syndrome.Methods: Ethical clearance was obtained from the Institutional Ethical Committee. A total of 40 obese women with the polycystic ovarian syndrome (PCOS) were selected and divided into two groups, Group A (N=17) received conventional physiotherapy alone, and Group B (n=15) received lifestyle modification along with conventional physiotherapy. The preassessment of body weight is measured by body mass index (BMI); the waist-hip ratio (W-H ratio) and body fat percentage and the quality of life were scored as per the PCOS questionnaire (PCOSQ); and postinterventional assessment was taken for the same after 9 months.Result: Intergroup statistical analysis for BMI revealed extremely significant in postintervention for Group B (P<0.0001). W-H ratio and PCOSQ were extremely significant for Group B (P<0.0001). While postintervention analysis showed extremely significant difference between Group A and Group B (P<0.0001). Group B treated with lifestyle modification, and conventional physiotherapy was extremely significant.Conclusion: Lifestyle modification with conventional physiotherapy helped in reducing weight and showed the increased quality of life in women with PCOS.

Weight loss following bariatric surgery in women with polycystic ovarian syndrome and oligomenorrhea

2016 ◽  
Vol 12 (7) ◽  
pp. s121-s122
Author(s):  
Sarah Pivo ◽  
Margaret Nachtigall ◽  
Patricia Chui ◽  
Akuezunkpa Ude Welcome ◽  
John Saunders ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Weight Loss ◽  
Polycystic Ovarian Syndrome ◽  
Ovarian Syndrome
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