Differential effects of low birthweight and intrauterine growth restriction on umbilical cord blood insulin-like growth factor concentrations

2015 ◽  
Vol 83 (5) ◽  
pp. 739-745 ◽  
Author(s):  
Anja Tzschoppe ◽  
Christina Riedel ◽  
Rüdiger von Kries ◽  
Ellen Struwe ◽  
Wolfgang Rascher ◽  
...  
Keyword(s):  
Growth Factor ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Intrauterine Growth Restriction ◽  
Low Birthweight ◽  
Growth Restriction ◽  
Insulin Like Growth Factor ◽  
Blood Insulin ◽  
Intrauterine Growth

scholarly journals Caffeine Metabolites in Umbilical Cord Blood, Cytochrome P-450 1A2 Activity, and Intrauterine Growth Restriction

2006 ◽  
Vol 163 (11) ◽  
pp. 1035-1041 ◽  
Author(s):  
Laura M. Grosso ◽  
Elizabeth W. Triche ◽  
Kathleen Belanger ◽  
Neal L. Benowitz ◽  
Theodore R. Holford ◽  
...  
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Intrauterine Growth Restriction ◽  
Growth Restriction ◽  
Intrauterine Growth ◽  
Cytochrome P 450

scholarly journals Carboxyhemoglobin Levels in Umbilical Cord Blood of Women With Preeclampsia and Intrauterine Growth Restriction

2010 ◽  
Vol 15 (suppl_A) ◽  
pp. 33A-33A
Author(s):  
K Yusuf ◽  
M Kamaluddeen ◽  
E Al-awad ◽  
RA Finch ◽  
B Caron ◽  
...  
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Intrauterine Growth Restriction ◽  
Growth Restriction ◽  
Intrauterine Growth

scholarly journals Insights into intrauterine growth restriction based on maternal and umbilical cord blood metabolomics

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Georgios Moros ◽  
Theodora Boutsikou ◽  
Charalambos Fotakis ◽  
Zoe Iliodromiti ◽  
Rozeta Sokou ◽  
...  
Keyword(s):  
Amino Acids ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Intrauterine Growth Restriction ◽  
Maternal Blood ◽  
Growth Restriction ◽  
Fetal Mortality ◽  
Orthogonal Projections ◽  
Intrauterine Growth

AbstractIntrauterine growth restriction (IUGR) is a fetal adverse condition, ascribed by limited oxygen and nutrient supply from the mother to the fetus. Management of IUGR is an ongoing challenge because of its connection with increased fetal mortality, preterm delivery and postnatal pathologies. Untargeted nuclear magnetic resonance (1H NMR) metabolomics was applied in 84 umbilical cord blood and maternal blood samples obtained from 48 IUGR and 36 appropriate for gestational age (AGA) deliveries. Orthogonal projections to latent structures discriminant analysis (OPLS-DA) followed by pathway and enrichment analysis generated classification models and revealed significant metabolites that were associated with altered pathways. A clear association between maternal and cord blood altered metabolomic profile was evidenced in IUGR pregnancies. Increased levels of the amino acids alanine, leucine, valine, isoleucine and phenylalanine were prominent in IUGR pregnancies indicating a connection with impaired amino acid metabolism and transplacental flux. Tryptophan was individually connected with cord blood discrimination while 3-hydroxybutyrate assisted only maternal blood discrimination. Lower glycerol levels in IUGR samples ascribed to imbalance between gluconeogenesis and glycolysis pathways, suggesting poor glycolysis. The elevated levels of branched chain amino acids (leucine, isoleucine and valine) in intrauterine growth restricted pregnancies were linked with increased insulin resistance.

Sign in / Sign up

Export Citation Format

Share Document