Reference values for serum dehydroepiandrosterone-sulphate in healthy children and adolescents with emphasis on the age of adrenarche and pubarche

2014 ◽  
Vol 82 (5) ◽  
pp. 712-718 ◽  
Author(s):  
Tulay Guran ◽  
Irfan Firat ◽  
Feyza Yildiz ◽  
Ipek Kaplan Bulut ◽  
Mahmut Dogru ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Reference Values ◽  
Healthy Children ◽  
Dehydroepiandrosterone Sulphate

Abstract 170: Re-evaluation of Carotid Intima-Media Thickness by Z-score in Children and Adolescents After Kawasaki Disease

Circulation ◽  
2015 ◽  
Vol 131 (suppl_2) ◽  
Author(s):  
Nobutaka Noto ◽  
Masataka Kato ◽  
Yuriko Abe ◽  
Hiroshi Kamiyama ◽  
Kensuke Karasawa ◽  
...  
Keyword(s):  
Kawasaki Disease ◽  
Children And Adolescents ◽  
Reference Values ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Specific Reference ◽  
Healthy Children ◽  
Media Thickness ◽  
Z Scores ◽  
The Mean

Objectives: The carotid intima-media thickness (CIMT) is a reliable screening method for vascular alterations even in a pediatric cohort; however, reference values of CIMT established recently by LMS methods for childhood and adolescence are limited when comparing patients after Kawasaki disease (KD) and controls. We tested the hypothesis that there are significant differences between the values of CIMT expressed as absolute values and z-scores in children and adolescents after KD and controls. Methods: We reviewed 12 published articles regarding CIMT on patients after KD and controls. Absolute values (Ab) of the mean±1 SD of CIMT in patients after KD and controls were transformed to z-scores (Zs) using age-specific reference values established by Jourdan et al. (J: 247 Caucasian subjects aged 10-20 years) and our own data (O: 175 Asian subjects aged 6-20 years), and the results were compared between the two references. In this study, the mean age of the study population derived from each article was designated the representative age for transformation. Results: In either reference (J) or (O), there was no significant sex difference in CIMT at any given age. The mean CIMT of (Ab) and (Zs) transformed by (J) or (O) were significantly different between patients after KD and controls, at 41.6% (Ab), 66.6% (Zs) by (J), and 83.3% (Zs) by (O) among 12 articles, respectively. Therefore, patients after KD had significantly higher (Zs) by (O) than those of controls (0.66±0.71 vs. 0.03±0.68, p=0.006, respectively). Compared with reference values, the controls of (O) were within the normal range. However, there were no significant differences in (Zs) by (J) between the two groups (1.72±0.77 vs. 1.23±0.83, p=0.116, respectively). When we assessed 9 articles dealing with Asian subjects, the difference of (Zs) between the two groups remained significant only by (O) (p=0.015). In contrast, when we assessed 3 articles dealing with mainly Caucasian subjects, there was no significant difference in (Zs) between the two groups with both (J) and (O). Conclusions: These results indicate that age and race-specific reference values for CIMT are mandatory for performing an accurate assessment of the vascular status in healthy children and adolescents and particularly in those after KD.

scholarly journals Aortic Pulse Wave Velocity in Healthy Children and Adolescents: Reference Values for the Vicorder Device and Modifying Factors

2015 ◽  
Vol 28 (12) ◽  
pp. 1480-1488 ◽  
Author(s):  
Daniela Thurn ◽  
Anke Doyon ◽  
Betul Sözeri ◽  
Aysun K. Bayazit ◽  
Nur Canpolat ◽  
...  
Keyword(s):  
Pulse Wave Velocity ◽  
Children And Adolescents ◽  
Wave Velocity ◽  
Reference Values ◽  
Pulse Wave ◽  
Aortic Pulse Wave Velocity ◽  
Healthy Children ◽  
Modifying Factors

Reference values for leptin/adiponectin ratio in healthy children and adolescents

2019 ◽  
Vol 493 ◽  
pp. 123-128 ◽  
Author(s):  
Ulrik Lausten-Thomsen ◽  
Morten Asp Vonsild Lund ◽  
Christine Frithioff-Bøjsøe ◽  
Paula Louise Hedley ◽  
Oluf Pedersen ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Reference Values ◽  
Healthy Children

Paediatric reference intervals for 17 Roche cobas 8000 e602 immunoassays in the CALIPER cohort of healthy children and adolescents

2019 ◽  
Vol 57 (12) ◽  
pp. 1968-1979 ◽  
Author(s):  
Mary Kathryn Bohn ◽  
Victoria Higgins ◽  
Shervin Asgari ◽  
Felix Leung ◽  
Barry Hoffman ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Reference Values ◽  
Laboratory Tests ◽  
Clinical Decision Making ◽  
Reference Intervals ◽  
Healthy Children ◽  
Serum Samples ◽  
Clinical Laboratories ◽  
Age And Sex ◽  
Roche Cobas

Abstract Background The diagnostic utility of laboratory tests in paediatric medicine relies heavily on the availability of appropriate reference intervals (RIs). The Canadian Laboratory Initiative on Paediatric Reference Intervals (CALIPER) has established a comprehensive database of covariate-stratified RIs for many paediatric laboratory tests using a large, healthy reference population. Several automated analysers in widespread use in clinical laboratories have already been studied. Here, we extend the testing to Roche immunoassays and report, for the first time, comprehensive paediatric RIs for 17 endocrine and special chemistry markers. Methods A total of 741 healthy children and adolescents (1 day to <19 years) were recruited and serum samples were analysed for 17 immunoassays on the Roche cobas 8000 e602 Immunoassay Analyzer. Age and sex-specific RIs were established and corresponding 90% confidence intervals (CIs) were calculated in accordance with Clinical and Laboratory Standards Institute guidelines. Results Reference values for all analytes measured required age partitioning, particularly during early life and throughout adolescence. Of the 17 analytes measured, eight required sex partitioning, including ferritin, thyroid stimulating hormone (TSH), total triiodothyronine (TT3) and all fertility/sex hormones, except prolactin. Conclusions This is the first study to determine accurate paediatric RIs for Roche immunoassays. RIs were generally similar to those previously published by CALIPER on other analytical platforms, highlighting the reproducibility of age- and sex-specific trends in reference values observed across the paediatric age range. The RIs established in this study will improve the accuracy of test result interpretation and clinical decision-making in clinical laboratories utilising Roche immunoassays.

Reference Values for Immunoglobulin Kappa and Lambda Light Chains and the Kappa/Lambda Ratio in Children's Serum

1992 ◽  
Vol 38 (12) ◽  
pp. 2454-2457 ◽  
Author(s):  
M Saitta ◽  
A Iavarone ◽  
N Cappello ◽  
M R Bergami ◽  
G C Fiorucci ◽  
...  
Keyword(s):  
Immune System ◽  
Children And Adolescents ◽  
Reference Values ◽  
Light Chains ◽  
Healthy Children ◽  
Serum Samples ◽  
Immunoglobulin Synthesis ◽  
Immunoglobulin Kappa

Abstract We analyzed 708 serum samples from healthy children and adolescents by immunonephelometry to obtain reference values for the immunoglobulin kappa (kappa) and lambda (lambda) light chains and for their ratio at a time of life when immunoglobulin synthesis is maturing and continually being stimulated. The lambda chain concentration that is to be maintained throughout the child's life is reached very early, just after 1 year, whereas the concentration of the kappa chains, which increases gradually, reflects the concentration of the immunoglobulins as a whole. These reference values may be useful for studying kappa and lambda chains in illnesses involving the immune system in children.

Reference values for fasting serum resistin in healthy children and adolescents

2017 ◽  
Vol 469 ◽  
pp. 161-165 ◽  
Author(s):  
Ulrik Lausten-Thomsen ◽  
Michael Christiansen ◽  
Paula Louise Hedley ◽  
Tenna Ruest Haarmark Nielsen ◽  
Cilius Esmann Fonvig ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Reference Values ◽  
Healthy Children ◽  
Fasting Serum

scholarly journals Reference Values for Inspiratory Muscle Endurance in Healthy Children and Adolescents

PLoS ONE ◽  
2017 ◽  
Vol 12 (1) ◽  
pp. e0170696 ◽  
Author(s):  
Cristhiele Taís Woszezenki ◽  
João Paulo Heinzmann-Filho ◽  
Fernanda Maria Vendrusculo ◽  
Taila Cristina Piva ◽  
Isadora Levices ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Reference Values ◽  
Inspiratory Muscle ◽  
Muscle Endurance ◽  
Healthy Children

scholarly journals Reference values and validation of the 1-minute sit-to-stand test in healthy 5–16-year-old youth: a cross-sectional study

BMJ Open ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. e049143
Author(s):  
Sarah R Haile ◽  
Thea Fühner ◽  
Urs Granacher ◽  
Julien Stocker ◽  
Thomas Radtke ◽  
...  
Keyword(s):  
Construct Validity ◽  
Children And Adolescents ◽  
Reference Values ◽  
Exercise Test ◽  
Learning Effect ◽  
Healthy Children ◽  
Short Term ◽  
Cross Sectional ◽  
Convenience Sample ◽  
Sit To Stand

ObjectivesIt is essential to have simple, reliable and valid tests to measure children’s functional capacity in schools or medical practice. The 1-minute sit-to-stand (STS) test is a quick fitness test requiring little equipment or space that is increasingly used in both healthy populations and those with chronic disease. We aimed to provide age-specific and sex-specific reference values of STS test in healthy children and adolescents and to evaluate its short-term reliability and construct validity.Design setting and participantsCross-sectional convenience sample from six public schools and one science fair in central Europe. Overall, 587 healthy participants aged 5–16 years were recruited and divided into age groups of 3 years each.Outcomes1-minute STS. To evaluate short-term reliability, some children performed the STS test twice. To evaluate construct validity, some children also performed a standing long jump (SLJ) and a maximal incremental exercise test.ResultsData from 547 youth aged 5–16 years were finally included in the analyses. The median number of repetitions in 1 min in males (females) ranged from 55 [95% CI: 38 to 72] (53 [95% CI: 35 to 76]) in 14–16-year olds to 59 [95% CI: 41 to 77] (60 [95% CI: 38 to 77]) in 8–10-year olds. Children who repeated STS showed a learning effect of on average 4.8 repetitions more than the first test (95% limits of agreement: −6.7 to 16.4). Moderate correlations were observed between the STS and the SLJ (r=0.48) tests and the maximal exercise test (r=0.43).ConclusionsThe reported STS reference values can be used to interpret STS test performance in children and adolescents. The STS appears to have good test–retest reliability, but a learning effect of about 10%. The association of STS with other measures of physical fitness should be further explored in a larger study and technical standards for its conduct are needed.

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