Statin use and thyroid cancer: a population-based case-control study

2014 ◽  
Vol 83 (1) ◽  
pp. 111-116 ◽  
Author(s):  
Shih-Han Hung ◽  
Herng-Ching Lin ◽  
Shiu-Dong Chung
Author(s):  
Mohammad Taher Parad ◽  
Mohammad Fararouei ◽  
Ali Reza Mirahmadizadeh ◽  
Sima Afrashteh

2015 ◽  
Vol 95 (2) ◽  
pp. 227-232 ◽  
Author(s):  
C.Y. Huang ◽  
S.D. Chung ◽  
L.T. Kao ◽  
H.C. Lin ◽  
L.H. Wang

Introduction: Statin may induce epithelial dysfunction of the bladder urothelium. Epithelial dysfunction was proposed as one of the major potential etiologies for bladder pain syndrome/interstitial cystitis (BPS/IC). In this study, we examined the association between statin use and BPS/IC using a population-based study. Subjects and Methods: This case-control study used the Taiwan Longitudinal Health Insurance Database. In total, 815 female subjects with BPS/IC and 4075 randomly selected female controls were included. We used a conditional logistic regression to compute the odds ratio (OR) for having previously used statins between cases and controls. Results: A conditional logistic regression analysis showed that the OR of prior statin users for cases was 1.52 (95% confidence interval (CI): 1.19-1.94) compared to controls after adjusting for diabetes, hypertension, coronary heart disease, obesity, chronic pelvic pain, irritable bowel syndrome, fibromyalgia, chronic fatigue syndrome, depression, panic disorder, migraines, sicca syndrome, allergies, endometriosis, and asthma. Furthermore, adjusted ORs of regular and irregular statin use for cases were 1.58 (95% CI: 1.20-2.08) and 1.53 (95% CI: 1.02-2.31), respectively, compared to controls. Conclusion: We concluded that there was an association between statin use and BPS/IC.


1994 ◽  
Vol 5 (5) ◽  
pp. 433-439 ◽  
Author(s):  
Jens P. Berg ◽  
Eystein Glattre ◽  
Tor Haldorsen ◽  
Arne T. Høstmark ◽  
Ida G. Bay ◽  
...  

2013 ◽  
Vol 12 (3) ◽  
pp. 293-298 ◽  
Author(s):  
Te-Fu Chan ◽  
Hui-Fen Chiu ◽  
Chen-Hsuan Wu ◽  
Chih-Lung Lin ◽  
Chun-Yuh Yang

Epidemiology ◽  
2006 ◽  
Vol 17 (Suppl) ◽  
pp. S306
Author(s):  
F DE Vathaire ◽  
P Brindel ◽  
F Doyon ◽  
J Paaoafaite ◽  
J Teuri ◽  
...  

2021 ◽  
Vol 50 (Supplement_1) ◽  
Author(s):  
Melanie Paquet ◽  
Dominique Baron-Dubourdieu ◽  
Pascal Guénel ◽  
Thérèse Truong

Abstract Background Aetiology of differentiated thyroid cancer is poorly understood. Among the risk factors strongly suspected to be involved in thyroid carcinogenesis are dietary factors. Recent evidence suggests polyphenols (i.e., natural bioactive compounds found in plant species), and their anticancer properties, may deserve closer epidemiological attention. Therefore, we examined the association between polyphenol intake levels and thyroid cancer risk in New Caledonia – a Pacific archipelago with some of the highest recorded thyroid cancer incidence rates in the world. Methods Food frequency questionnaire information from a population-based case-control study was used. Daily lignan and flavonoid intakes, expressed as aglycone equivalents, were estimated using Phenol-Explorer and relevant USDA databases. Unconditional logistic regression analyses were performed on data from 324 histologically confirmed cases of papillary or follicular carcinoma, diagnosed from 1993 to 1999, and 402 controls. Polyphenol intakes were analysed as both continuous and categorical variables (quartiles). Results Estimated median flavonoid and lignan intakes were 351.0 and 2.6 mg, respectively. When adjusting for sex, age, ethnic community, province of residence, BMI, smoking status, alcohol consumption and energy intake, no association with differentiated thyroid cancer risk was observed for flavonoids (OR = 1.06, 95% CI: 0.66, 1.70; comparing extreme quartiles), but a negative association was demonstrated for lignans (ORQ4vs.Q1=0.60, 95% CI: 0.37, 0.96; comparing extreme quartiles). Conclusions Our findings suggest that lignans may exert a protective effect on differentiated thyroid cancer. However, large-scale cohort studies and further analytical data on lignans are required to confirm this association. Key messages Lignans may play a role in thyroid carcinogenesis.


Lung Cancer ◽  
2012 ◽  
Vol 75 (3) ◽  
pp. 275-279 ◽  
Author(s):  
Meng-Hsuan Cheng ◽  
Hui-Fen Chiu ◽  
Shu-Chen Ho ◽  
Chun-Yuh Yang

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