scholarly journals Cortical bone mineral density in patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency

2014 ◽  
Vol 82 (3) ◽  
pp. 330-337 ◽  
Author(s):  
Diala El-Maouche ◽  
Suzanne Collier ◽  
Mala Prasad ◽  
James C. Reynolds ◽  
Deborah P. Merke
Keyword(s):  
Bone Mineral Density ◽  
Congenital Adrenal Hyperplasia ◽  
Cortical Bone ◽  
Bone Mineral ◽  
Adrenal Hyperplasia ◽  
Mineral Density ◽  
Hydroxylase Deficiency ◽  
Cortical Bone Mineral Density ◽  
21 Hydroxylase Deficiency

Classical congenital adrenal hyperplasia due to 21-hydroxylase deficiency: a cross-sectional study of factors involved in bone mineral density

2003 ◽  
Vol 21 (6) ◽  
pp. 396-401 ◽  
Author(s):  
Patr�cia Oliveira de Almeida Freire ◽  
Sofia Helena Valente de Lemos-Marini ◽  
Andr�a Trevas Maciel-Guerra ◽  
Andr� Moreno Morcillo ◽  
Maria Tereza Matias Baptista ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Congenital Adrenal Hyperplasia ◽  
Bone Mineral ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Adrenal Hyperplasia ◽  
Mineral Density ◽  
Hydroxylase Deficiency ◽  
Cross Sectional ◽  
21 Hydroxylase Deficiency

scholarly journals Bone mineral density, bone markers, and fractures in adult males with congenital adrenal hyperplasia

2013 ◽  
Vol 168 (3) ◽  
pp. 331-341 ◽  
Author(s):  
Henrik Falhammar ◽  
Helena Filipsson Nyström ◽  
Anna Wedell ◽  
Kerstin Brismar ◽  
Marja Thorén
Keyword(s):  
Bone Mineral Density ◽  
Congenital Adrenal Hyperplasia ◽  
Bone Metabolism ◽  
Bone Mineral ◽  
Hormonal Control ◽  
Adult Males ◽  
Adrenal Hyperplasia ◽  
Mineral Density ◽  
Poor Control ◽  
21 Hydroxylase Deficiency

ObjectiveThe aim of this study was to determine bone mineral density (BMD), markers of bone metabolism, fractures, and steroids reflecting hormonal control in adult males with congenital adrenal hyperplasia (CAH).Subjects, methods, and designWe compared CAH males with 21-hydroxylase deficiency (n=30), 19–67 years old, with age- and sex-matched controls (n=32). Subgroups ofCYP21A2genotypes, age, glucocorticoid preparation, poor control vs overtreatment, and early vs late (>36 months) diagnosis were studied. BMD measured by dual energy X-ray absorptiometry and markers of bone metabolism and androgens/17-hydroxyprogesterone levels were investigated.ResultsAll, including older (>30 years), CAH patients had lower BMD in all measured sites compared with control subjects. The null group demonstrated lower BMD in more locations than the other groups. Osteoporosis/osteopenia was present in 81% of CAH patients compared with 32% in controls (≥30 years). Fracture frequency was similar, osteocalcin was lower, and fewer patients than controls had vitamin D insufficiency. IGF1 was elevated in the milder genotypes. In patients, total body BMD was positively correlated to weight, BMI, total lean body mass, and triglycerides, and negatively to prolactin. Patients on prednisolone had lower BMD and osteocalcin levels than those on hydrocortisone/cortisone acetate. Patients with poor control had higher femoral neck BMD. There were no differences in BMD between patients with an early vs late diagnosis.ConclusionsCAH males have low BMD and bone formation markers. BMD should be monitored, adequate prophylaxis and treatment established, and glucocorticoid doses optimized to minimize the risk of future fractures.

scholarly journals A Metabolic Screen in Adolescents Reveals an Association Between Circulating Citrate and Cortical Bone Mineral Density

2019 ◽  
Vol 34 (7) ◽  
pp. 1306-1313 ◽  
Author(s):  
John P Kemp ◽  
Adrian Sayers ◽  
William D Fraser ◽  
George Davey Smith ◽  
Mika Ala‐Korpela ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Cortical Bone ◽  
Bone Mineral ◽  
Mineral Density ◽  
Cortical Bone Mineral Density

scholarly journals Fat Mass Exerts a Greater Effect on Cortical Bone Mass in Girls than Boys

2010 ◽  
Vol 95 (2) ◽  
pp. 699-706 ◽  
Author(s):  
Adrian Sayers ◽  
Jonathan H. Tobias
Keyword(s):  
Bone Mineral Density ◽  
Bone Mass ◽  
Cortical Bone ◽  
Bone Mineral ◽  
Fat Mass ◽  
Quantitative Computed Tomography ◽  
Positive Association ◽  
Mineral Density ◽  
Cortical Bone Mineral Density ◽  
Cortical Bone Mass

Abstract Context: It is unclear whether fat mass (FM) and lean mass (LM) differ in the way they influence cortical bone development in boys and girls. Objective: The aim of the study was to investigate the contributions of total body FM and LM to parameters related to cortical bone mass and geometry. Design/Setting: We conducted a longitudinal birth cohort study, the Avon Longitudinal Study of Parents and Children. Participants: A total of 4005 boys and girls (mean age, 15.5 yr) participated in the study. Outcome Measures: We measured cortical bone mass, cortical bone mineral content (BMCC), cortical bone mineral density, periosteal circumference (PC), and endosteal circumference by tibial peripheral quantitative computed tomography. Results: LM had a similar positive association with BMCC in boys and girls [regression coefficients with 95% confidence interval (CI); P for gender interactions: boys/girls, 0.952 (0.908, 0.997); P = 0.85]. However, the mechanisms by which LM influenced bone mass differed according to gender because LM was positively associated with PC more strongly in girls [boys, 0.579 (0.522, 0.635); girls, 0.799 (0.722, 0.875); P < 0.0001], but was only associated with cortical bone mineral density in boys [boys, 0.443 (0.382, 0.505); girls, 0.014 (−0.070, 0.097); P < 0.0001]. There was a stronger positive association between FM and BMCC in girls [boys, 0.227 (0.185, 0.269); girls, 0.355 (0.319, 0.392); P < 0.0001]. This reflected both a greater positive association of FM with PC in girls [boys, 0.213 (0.174, 0.253); girls, 0.312 (0.278, 0.347); P = 0.0002], and a stronger negative association with endosteal circumferencePC [boys, −0.059 (−0.096, 0.021); girls, −0.181 (−0.215, −0.146); P < 0.0001]. Conclusions: Whereas LM stimulates the accrual of cortical bone mass to a similar extent in boys and girls, FM is a stronger stimulus for accrual of cortical bone mass in girls, reflecting a greater tendency in females for FM to stimulate periosteal growth and suppress endosteal expansion.

Sign in / Sign up

Export Citation Format

Share Document