scholarly journals Blood pressure, fludrocortisone dose and plasma renin activity in children with classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency followed from birth to 4 years of age

2014 ◽  
Vol 81 (6) ◽  
pp. 871-875 ◽  
Author(s):  
Walter Bonfig ◽  
Hans Peter Schwarz
Keyword(s):  
Blood Pressure ◽  
Plasma Renin Activity ◽  
Congenital Adrenal Hyperplasia ◽  
Plasma Renin ◽  
Renin Activity ◽  
Adrenal Hyperplasia ◽  
Hydroxylase Deficiency ◽  
Classic Congenital Adrenal Hyperplasia ◽  
21 Hydroxylase Deficiency

scholarly journals Association Between Plasma Renin Activity with Hypertension in Children with Congenital Adrenal Hyperplasia due to 21-Hydroxylase Enzyme Deficiency

2021 ◽  
Author(s):  
Siska Mayasari Lubis ◽  
Eka Lakshmi Hidayati ◽  
Frida Soesanti ◽  
Bambang Tridjaja AAP
Keyword(s):  
Plasma Renin Activity ◽  
Congenital Adrenal Hyperplasia ◽  
Plasma Renin ◽  
Cross Sectional Study ◽  
Renin Activity ◽  
Enzyme Deficiency ◽  
Activity Levels ◽  
Adrenal Hyperplasia ◽  
Cross Sectional ◽  
Salt Wasting

Abstract BackgroundHypertension is an uncommon manifestation of congenital adrenal hyperplasia due to 21-hydroxylase enzyme deficiency (21-OHD CAH). Nevertheless, it is necessary to continuously be aware of hypertension incidence in 21-OHD CAH patients and its possible causes. Conflicting results regarding the role of PRA have been reported. This study aims to evaluate the association between plasma renin activity levels (PRA) with hypertension in 21-OHD CAH children. MethodsWe did an observational analytic study with a cross-sectional study design. The subjects were 21-OHD CAH children, aged >6 months to 18 years, selected by consecutive sampling and then compared between 21-OHD CAH with hypertension and non-hypertension groups. We gathered 40 subjects, 20 subjects in hypertension and 20 subjects in non-hypertension groups.ResultsThere were 16 from 27 (59.3%) and 4 from 13 subjects (30.8%) with hypertension in salt-wasting and simple virilizing type, respectively. There was a significant mean difference in PRA levels between hypertension and non-hypertension groups in salt wasting patients (p=0,016). The risk of hypertension in salt wasting patients with low PRA levels was 1,09 times after controlling for sex, 17-OHP levels, and the last fludrocortisone dose. The last dose of hydrocortisone had a significant relationship with the incidence of hypertension in salt wasting patients. ConclusionsThis study concludes that hypertension in 21-OHD CAH patients during the study period was 32%. The risk of hypertension in salt wasting patients with low PRA levels was 1.09 times after being controlled for sex, 17 OHP level, and the last dose of fludrocortisone.

PLASMA RENIN ACTIVITY AND ALDOSTERONE SECRETION IN CONGENITAL ADRENAL HYPERPLASIA

1967 ◽  
Vol 56 (1_Suppl) ◽  
pp. S84 ◽  
Author(s):  
A. F. Muller ◽  
C. Godard ◽  
A. M. Riondel ◽  
R. Veyrat ◽  
A. Mégevand
Keyword(s):  
Plasma Renin Activity ◽  
Congenital Adrenal Hyperplasia ◽  
Plasma Renin ◽  
Renin Activity ◽  
Adrenal Hyperplasia ◽  
Aldosterone Secretion
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