Clinical usefulness of growth hormone secretion elicited by acute stimulation tests

2013 ◽  
Vol 79 (2) ◽  
pp. 168-169
Author(s):  
Audí Laura ◽  
Carrascosa Antonio
Keyword(s):  
Growth Hormone ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Clinical Usefulness ◽  
Stimulation Tests

scholarly journals Evaluation of Prepubertal Patients with Suspected Neurosecretory Dysfunction of Growth Hormone Secretion: Diagnostic Steps and Treatment Response

2017 ◽  
Vol 2017 ◽  
pp. 1-11
Author(s):  
Carmen Sydlik ◽  
Claudia Weißenbacher ◽  
Julia Roeb ◽  
Susanne Bechtold-Dalla Pozza ◽  
Heinrich Schmidt
Keyword(s):  
Growth Hormone ◽  
Hormone Secretion ◽  
Laboratory Data ◽  
Growth Hormone Secretion ◽  
Diagnostic Procedures ◽  
Gh Treatment ◽  
Gh Secretion ◽  
Significant Difference ◽  
Stimulation Tests

Background and Aims. Existence and diagnostic procedures of neurosecretory dysfunction of growth hormone (NSD) are still a matter of debate. The aim of our study was (a) to find out if prediagnostic auxological and laboratory data could serve as an indicator for pathologic and normal spontaneous GH-secretion and (b) to evaluate the response to GH-therapy in NSD-patients. Methods. Of 90 children (unicentric study) with normal response to GH-stimulation tests, in whom 12-hour night profiles for GH-secretion were performed, 49 were diagnosed with NSD (NSD group). Their auxologic data, IGF-I/IGFBP3-levels as well as the night profiles, were analysed and compared to those of the non-NSD group. Additionally, follow-up auxological data of the GH-treated NSD-patients were collected. Results. Prediagnostic auxologic and laboratory data did not differ between the two groups. Instead, for all analysed criteria of spontaneous GH-secretion (number of peaks, maximal and mean secretion) a significant difference was found. Children with NSD showed a good response to GH-treatment after 1 (ΔH-SDS +0,77 ± 0,48) as well as 4 years (+1,51 ± 0,75). Conclusion. According to our results, analysing spontaneous GH-secretion remains the only method to identify NSD. Yet, as response to GH-treatment is comparable to results in idiopathic GHD, it is worth to consider this diagnosis.

Endocrine disturbances in suprasellar germinomas

1989 ◽  
Vol 120 (3) ◽  
pp. 337-342 ◽  
Author(s):  
M. Buchfelder ◽  
R. Fahlbusch ◽  
M. Walther ◽  
K. Mann
Keyword(s):  
Growth Hormone ◽  
Differential Diagnosis ◽  
Diabetes Insipidus ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Comparison Of Results ◽  
Endocrine Disturbances ◽  
Stimulation Tests ◽  
Suprasellar Tumours

Abstract. The authors have investigated hypothalamicpituitary function in 8 patients (aged 9–27 years) with surgically and histologically proven suprasellar germinomas. Diabetes insipidus was found in 7 patients. All the patients had hypogonadism and hypocortisolism as judged by dynamic endocrine testing. Hypothyroidism was found in 6. Moreover, growth hormone secretion, as assessed by insulin-induced hypoglycemia, was defective in all patients. Comparison of results of insulin-induced hypoglycemia testing and stimulation tests by CRH and GHRH suggested that all patients had a primary supra-hypohypophyseal lesion rather than a primary pituitary defect. The authors conclude that suprasellar germinomas, although uncommon, should be included in the differential diagnosis of juvenile suprasellar tumours and in cases suggestive of idiopathic diabetes insipidus, even if neuroradiological investigation fails to demonstrate a discrete tumour.

THE EFFECT OF BETA-RECEPTOR BLOCKADE ON EXERCISE AND ARGININE-INDUCED GROWTH HORMONE SECRETION IN MAN

1974 ◽  
Vol 77 (1_Suppl) ◽  
pp. S6 ◽  
Author(s):  
S. Raptis ◽  
H. Hirth-Schmidt ◽  
K. E. Schröder ◽  
E. F. Pfeiffer
Keyword(s):  
Growth Hormone ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Receptor Blockade ◽  
Beta Receptor ◽  
Beta Receptor Blockade

Growth hormone secretion in children treated for medulloblastoma

2018 ◽  
Author(s):  
Alexey Kalinin ◽  
Natalia Strebkova ◽  
Olga Zheludkova ◽  
Maria Kareva
Keyword(s):  
Growth Hormone ◽  
Hormone Secretion ◽  
Growth Hormone Secretion
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