scholarly journals Prevalence and long-term follow-up outcomes of testicular adrenal rest tumours in children and adolescent males with congenital adrenal hyperplasia

2013 ◽  
Vol 78 (5) ◽  
pp. 667-672 ◽  
Author(s):  
Zehra Aycan ◽  
Veysel N. Bas ◽  
Semra Cetinkaya ◽  
Sebahat Yilmaz Agladioglu ◽  
Tuğrul Tiryaki
Keyword(s):  
Congenital Adrenal Hyperplasia ◽  
Adolescent Males ◽  
Adrenal Hyperplasia ◽  
Children And Adolescent ◽  
Long Term Follow Up ◽  
Adrenal Rest ◽  
Testicular Adrenal Rest

Testicular adrenal rest tumors in patients with congenital adrenal hyperplasia: 6 years of follow-up

2019 ◽  
Vol 32 (5) ◽  
pp. 519-526 ◽  
Author(s):  
Gabriela Werneck ◽  
Enda M.R. Rodrigues ◽  
Rafael M. Mantovani ◽  
Jovita S.S. Lane ◽  
Ivani N. Silva
Keyword(s):  
Congenital Adrenal Hyperplasia ◽  
Tumor Progression ◽  
Repeated Measures ◽  
Laboratory Data ◽  
Hormonal Control ◽  
Adrenal Hyperplasia ◽  
Testicular Adrenal Rest Tumors ◽  
Adrenal Rest ◽  
Testicular Adrenal Rest

AbstractBackgroundTesticular adrenal rest tumors (TARTs) leading to primary gonadal failure are the main etiology of infertility in congenital adrenal hyperplasia (CAH). We aimed at identifying the evolution of TART and related findings in young CAH patients.MethodsTwelve male patients (3–23 years old) with 21-hydroxilase deficiency (11 with classic salt-wasting form) were included. Testicular ultrasonography (US) was performed in two moments, by a single blinded specialist in pediatric diagnostic imaging. Tumor progression was classified according to the Response Evaluation Criteria in Solid Tumors (RECIST). The clinical and laboratory data were retrieved from medical records. Serum 17-OH-progesterone (17OHP) and androstenedione concentrations were evaluated during the whole period of follow-up, from the CAH diagnosis. A logistic regression model with repeated measures was developed for the analysis.ResultsThe prevalence of TART was 41.6% (n = 5) in the initial US evaluation and 66.6% (n = 8) after 6 years of follow-up. Tumor progression was detected in 4 of the 5 patients, and 1 presented with a stable tumor. Three patients presented with new tumors in the second evaluation. Most of the patients (n = 11) were pubertal, including a 7-year-old child with TART who presented with central precocious puberty. At regression analysis, it was observed that an inadequate hormonal control led to a 16 times greater chance of a patient to present with TART (OR = 16.08; confidence interval [CI] 95% = 2.38–108.81; p = 0.004).ConclusionsWe found a high prevalence of progressive TART in young pubertal subjects. US testicular screening should help in improving therapeutic optimization in CAH patients to reduce future impairment in fertility.

scholarly journals Long-term Follow up of Congenital Adrenal Hyperplasia Patients with Hyponatremia

2007 ◽  
Vol 5 (2) ◽  
pp. 140 ◽  
Author(s):  
Jun Hyuk Song ◽  
Kyu Ha Lee ◽  
Sung Do Kim ◽  
Byoung Soo Cho
Keyword(s):  
Congenital Adrenal Hyperplasia ◽  
Adrenal Hyperplasia ◽  
Long Term Follow Up

616 Long term follow up of female patients with congenital adrenal hyperplasia

2015 ◽  
Vol 14 (2) ◽  
pp. e616
Author(s):  
B. Hong ◽  
J.H. Kim ◽  
J-H. Kim ◽  
J. Jung ◽  
S.H. Song ◽  
...  
Keyword(s):  
Congenital Adrenal Hyperplasia ◽  
Adrenal Hyperplasia ◽  
Female Patients ◽  
Long Term Follow Up

Long-term follow-up of congenital adrenal hyperplasia due to 11[beta]-hydroxylase deficiency

2018 ◽  
Author(s):  
Hamza Elfekih ◽  
Yosra Hasni ◽  
Wafa Badr ◽  
Asma Ben Abdelkrim ◽  
Bilel Ben Amor ◽  
...  
Keyword(s):  
Congenital Adrenal Hyperplasia ◽  
Adrenal Hyperplasia ◽  
Hydroxylase Deficiency ◽  
Long Term Follow Up

scholarly journals Large testicular adrenal rest tumours in a patient with congenital adrenal hyperplasia

2015 ◽  
Vol 2015 ◽  
Author(s):  
J Rajkanna ◽  
S O Oyibo
Keyword(s):  
Congenital Adrenal Hyperplasia ◽  
Support Groups ◽  
Testicular Tissue ◽  
List Type ◽  
Adrenal Hyperplasia ◽  
Prosthesis Replacement ◽  
Compliance To Treatment ◽  
Adrenal Rest ◽  
Testicular Adrenal Rest

Summary Testicular adrenal rest tumours (TARTs) are benign ACTH-dependent tumours that occur in males with congenital adrenal hyperplasia (CAH) and if left untreated can destroy testicular tissue. Corticosteroid suppressive treatment could result in the regression of these testicular tumours. We present a patient with bilateral large TARTs as a consequence of poor compliance to treatment and follow-up for his CAH, who consequently had to have bilateral orchidectomies and prosthesis replacement. Learning points TARTs are frequently seen in males with CAH, and can be misdiagnosed as primary testicular cancer. Patient compliance to treatment and follow-up are necessary to reduce the risk of testicular damage as a result of TARTs in patients with CAH. Boys with CAH should have periodic ultrasonographic screening from before adolescent age for early detection of TARTs. Regular monitoring of renin, 17-hydroxyprogesterone and androgens levels is required to assess corticosteroid suppressive treatment. Patients with CAH should be offered psychological support and information concerning CAH support groups.

Anorexia nervosa in congenital adrenal hyperplasia: long-term follow-up of 4 cases

2000 ◽  
Vol 108 (06) ◽  
pp. 430-435 ◽  
Author(s):  
M. Brand ◽  
E. Schoof ◽  
C.-J. Partsch ◽  
M. Peter ◽  
W. Hoepffner ◽  
...  
Keyword(s):  
Anorexia Nervosa ◽  
Congenital Adrenal Hyperplasia ◽  
Adrenal Hyperplasia ◽  
Long Term Follow Up
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