scholarly journals IgG antibody response against Plasmodium falciparum aminopeptidase 1 antigen in Gabonese children living in Makokou and Franceville

2020 ◽  
Vol 200 (3) ◽  
pp. 287-298
Author(s):  
S. L. Oyegue‐Liabagui ◽  
R.‐K. Imboumy‐Limoukou ◽  
C. L. Kouna ◽  
F. Bangueboussa ◽  
M. Schmitt ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Antibody Response ◽  
Igg Antibody

scholarly journals SEROPREVALENCE OF IMMUNOGLOBULIN IgG ANTIBODY RESPONSE TO PLASMODIUM FALCIPARUM MEROZOITE ANTIGENS AMONG CHILDREN IN MINNA, NORTH CENTRAL, NIGERIA

2021 ◽  
pp. 31-35
Author(s):  
YAMMAN-USMAN HADIJAH ◽  
OMALU CJ INNOCENT ◽  
ABUBAKAR ABDULKADIR ◽  
ABOLARINWA SO ◽  
EKE S SAMUEL ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Antibody Response ◽  
Strong Relationship ◽  
Cross Sectional Study ◽  
Enzyme Linked Immunosorbent Assay ◽  
Igg Antibody ◽  
Cross Sectional ◽  
Significant Difference ◽  
Falciparum Merozoite ◽  
Merozoite Antigens

Objective: A cross-sectional study was carried out in a representative cohort of children in Minna aged 6 months–17 years to determine the correlation between immunoglobulin G (IgG) antibody responses to Plasmodium falciparum merozoite antigens. Methods: Plasma samples from 93 children were exposed to Enzyme-Linked Immunosorbent Assay for the measurement of IgG antibody production against P. falciparum. Results: There was a high seroprevalence of IgG antibody against P. falciparum antigens tested with 74.20%. The seroprevalence for the male category was quite higher as compared with that of the female category, though, analysis using Mann–Whitney U-test revealed IgG antibody response to P. falciparum infection in the male was significantly different as compared to the female category (p<0.05). Furthermore, the prevalence of IgG antibody against P. falciparum antigen increased with age, with the lowest observed in 6 months–5 years 66.66%. Kruskal–Wallis H test showed a non-significant difference in the production of IgG antibody against P. falciparum antigen between different cohorts, and no correlation exists between them (p>0.05). An evidence of more than 50% was found for the production of IgG antibody by sub-microscopic parasite. On the other hand, microscopically positive P. falciparum samples recorded more seroprevalence of 68.81% as against negative samples, though significant difference between the negative and positive P. falciparum infected samples and the production of IgG antibody was not observed (p>0.05). Conclusion: This study has demonstrated a boosting immune responses by sub-microscopic parasite and also suggests a strong relationship between production of IgG antibody and malaria transmission, rather than protective immunity.

The profile of IgG-antibody response against merozoite surface proteins 1 and 2 in severe Plasmodium falciparum malaria in Eastern Sudan

2007 ◽  
Vol 102 (3) ◽  
pp. 401-409 ◽  
Author(s):  
Thoraya M E A-Elgadir ◽  
Mustafa I. Elbashir ◽  
Klavs Berzins ◽  
Emad M. Masuadi ◽  
Ishraga E A-Elbasit ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Antibody Response ◽  
Falciparum Malaria ◽  
Plasmodium Falciparum Malaria ◽  
Surface Proteins ◽  
Igg Antibody ◽  
Eastern Sudan

scholarly journals The Antibody Response to Plasmodium falciparum: Cues for Vaccine Design and the Discovery of Receptor-Based Antibodies

2019 ◽  
Vol 37 (1) ◽  
pp. 225-246 ◽  
Author(s):  
Joshua Tan ◽  
Luca Piccoli ◽  
Antonio Lanzavecchia
Keyword(s):  
Public Health ◽  
Plasmodium Falciparum ◽  
Immune System ◽  
Antibody Response ◽  
Public Health Problem ◽  
Vaccine Design ◽  
Immunoglobulin Genes ◽  
And Control ◽  
Sterilizing Immunity

Plasmodium falciparum remains a serious public health problem and a continuous challenge for the immune system due to the complexity and diversity of the pathogen. Recent advances from several laboratories in the characterization of the antibody response to the parasite have led to the identification of critical targets for protection and revealed a new mechanism of diversification based on the insertion of host receptors into immunoglobulin genes, leading to the production of receptor-based antibodies. These advances have opened new possibilities for vaccine design and passive antibody therapies to provide sterilizing immunity and control blood-stage parasites.

scholarly journals Prior COVID-19 Infection and Antibody Response to Single Versus Double Dose mRNA SARS-CoV-2 Vaccination

2021 ◽  
Author(s):  
Joseph E. Ebinger ◽  
Justyna Fert-Bober ◽  
Ignat Printsev ◽  
Min Wu ◽  
Nancy Sun ◽  
...  
Keyword(s):  
Antibody Response ◽  
Dose Regimen ◽  
Vaccine Dose ◽  
Double Dose ◽  
Igg Antibody ◽  
Vaccination Programs ◽  
Public Health Programs ◽  
Supply Chain Logistics ◽  
Potential Efficacy ◽  
Single Versus

The double dose regimen for mRNA vaccines against SARS-CoV-2 presents both a hope and a challenge for global efforts to curb the COVID-19 pandemic. With supply chain logistics impacting the rollout of population-scale vaccination programs, increasing attention has turned to the potential efficacy of single versus double dose vaccine administration for select individuals. To this end, we examined response to Pfizer-BioNTech mRNA vaccine in a large cohort of healthcare workers including those with versus without prior COVID-19 infection. For all participants, we quantified circulating levels of SARS-CoV-2 anti-spike (S) protein IgG at baseline prior to vaccine, after vaccine dose 1, and after vaccine dose 2. We observed that the anti-S IgG antibody response following a single vaccine dose in persons who had recovered from confirmed prior COVID-19 infection was similar to the antibody response following two doses of vaccine in persons without prior infection (P>0.57). Patterns were similar for the post-vaccine symptoms experienced by infection recovered persons following their first dose compared to the symptoms experienced by infection naive persons following their second dose (P=0.66). These results support the premise that a single dose of mRNA vaccine could provoke in COVID-19 recovered individuals a level of immunity that is comparable to that seen in infection naive persons following a double dose regimen. Additional studies are needed to validate our findings, which could allow for public health programs to expand the reach of population wide vaccination efforts.

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