scholarly journals Secretory antibodies to citrullinated peptides in plasma and saliva from rheumatoid arthritis patients and their unaffected first‐degree relatives

2019 ◽  
Vol 199 (2) ◽  
pp. 143-149
Author(s):  
A. Svärd ◽  
K. Roos Ljungberg ◽  
M. Brink ◽  
K. Martinsson ◽  
C. Sjöwall ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
First Degree Relatives ◽  
Secretory Antibodies

Association of adipokines with rheumatic disease activity indexes and periodontal disease in patients with early rheumatoid arthritis and their first‐degree relatives

2019 ◽  
Vol 22 (11) ◽  
pp. 1990-2000 ◽  
Author(s):  
Jeimy A. Chaparro‐Sanabria ◽  
Wilson Bautista‐Molano ◽  
Juan M. Bello‐Gualtero ◽  
Lorena Chila‐Moreno ◽  
Diana M. Castillo ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Rheumatic Disease ◽  
Periodontal Disease ◽  
Disease Activity ◽  
Early Rheumatoid Arthritis ◽  
First Degree Relatives ◽  
Rheumatic Disease Activity

Are obesity, ACPAs and periodontitis conditions that influence the risk of developing rheumatoid arthritis in first-degree relatives?

2016 ◽  
Vol 36 (4) ◽  
pp. 799-806 ◽  
Author(s):  
Sonia Unriza-Puin ◽  
Wilson Bautista-Molano ◽  
Gloria I Lafaurie ◽  
Rafael Valle-Oñate ◽  
Philippe Chalem ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
First Degree Relatives

scholarly journals Symptoms in first-degree relatives of patients with rheumatoid arthritis: evaluation of cross-sectional data from the symptoms in persons at risk of rheumatoid arthritis (SPARRA) questionnaire in the PRe-clinical EValuation of Novel Targets in RA (PREVeNT-RA) Cohort

2021 ◽  
Vol 23 (1) ◽  
Author(s):  
R. E. Costello ◽  
J. H. Humphreys ◽  
J. C. Sergeant ◽  
M. Haris ◽  
F. Stirling ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
At Risk ◽  
Logistic Regression ◽  
Joint Pain ◽  
Patient Characteristics ◽  
Cross Sectional ◽  
First Degree Relatives ◽  
Increased Risk ◽  
Large Joint ◽  
Small Joint

Abstract Background First-degree relatives (FDRs) of people with rheumatoid arthritis (RA) have a fourfold increased risk of developing RA. The Symptoms in Persons At Risk of Rheumatoid Arthritis (SPARRA) questionnaire was developed to document symptoms in persons at risk of RA. The aims of this study were (1) to describe symptoms in a cohort of FDRs of patients with RA overall and stratified by seropositivity and elevated CRP and (2) to determine if patient characteristics were associated with symptoms suggestive of RA. Methods A cross-sectional study of FDRs of patients with RA, in the PREVeNT-RA study, who completed a study questionnaire, provided a blood sample measured for rheumatoid factor, anti-CCP and CRP and completed the SPARRA questionnaire. Moderate/severe symptoms and symmetrical, small and large joint pain were identified and described. Symptoms associated with both seropositivity and elevated CRP were considered suggestive of RA. Logistic regression was used to determine if symptoms suggestive of RA were associated with patient characteristics. Results Eight hundred seventy participants provided all data, 43 (5%) were seropositive and 122 (14%) had elevated CRP. The most frequently reported symptoms were sleep disturbances (20.3%) and joint pain (17.9%). Symmetrical and small joint pain were 11.3% and 12.8% higher, respectively, in those who were seropositive and 11.5% and 10.7% higher in those with elevated CRP. In the logistic regression model, seropositivity, older age and feeling depressed were associated with increased odds of small and symmetrical joint pain. Conclusions This is the first time the SPARRA questionnaire has been applied in FDRs of patients with RA and has demonstrated that the presence of symmetrical and small joint pain in this group may be useful in identifying people at higher risk of developing RA.

scholarly journals Osteopontin, Osteoprotegerin and Musculoskeletal Ultrasound findings in First-Degree Relatives of Rheumatoid Arthritis: Potential Markers of Preclinical Disease

2020 ◽  
Author(s):  
Eiman Soliman ◽  
Sarah Ohrndorf ◽  
Magdy Zehairy ◽  
Khaled Matrawy ◽  
Abeer Alhadidy ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Bone Metabolism ◽  
Clinical Laboratory ◽  
Joint Inflammation ◽  
Musculoskeletal Ultrasound ◽  
First Degree Relatives ◽  
Preclinical Phase ◽  
Increased Risk ◽  
Significant Difference ◽  
Clinical Arthritis

Abstract Background: First-degree relatives (FDRs) of rheumatoid arthritis (RA) patients are known to have increased risk of developing the disease. The detection of altered bone metabolism in FDRs could be a predictor of the disease. Preclinical phase of RA is characterized by a state of autoimmunity and inflammation. Musculoskeletal ultrasound (MSUS) is known for its ability to detect subclinical joint inflammation in RA, but changes in FDRs are not yet described.Objectives: To study serum osteopontin (OPN) and osteoprotegerin (OPG) levels in first degree relatives (FDRs) of rheumatoid arthritis (RA) as markers of altered bone metabolism in relation to clinical, laboratory and musculoskeletal ultrasound (MSUS) findings. Methods: Fifty-five individuals were included, 20 had definite RA, 25 were FDRs of RA patients, and 10 healthy controls. Clinical evaluation for joint swelling/tenderness was performed for all. ESR, CRP, rheumatoid factor (RF), anti-citrullinated antibodies (ACPA), OPN, OPG, and MSUS by the US7 score were evaluated.Results: OPG was significantly higher in RA (143.89 pg/ml±365.47) than in FDRs (22.23 pg/ml±65.73; p=0.009) and controls (6.20 pg/ml±12.43; p=0.003). OPN was also higher in RA (3.66 ng/ml±4.20) than in FDRs (1.97 ng/ml±1.04) and controls (2.81 ng/ml±1.31), though not significant (p=0.102). Eight of 25 FDRs (32%) had arthralgia without clinical arthritis and 17/25 (68%) were asymptomatic. FDRs with arthralgia had significantly higher ESR and CRP levels than asymptomatic FDRs (9.82 mm/h±4.13; p=0.003, and 3.93 mg/l±3.58; p=0.003). OPG was higher in FDRs than in controls, and also in those with arthralgia (51.55 pg/ml±114.68) than in those without (8.44 pg/ml±9.67), though without significant difference. OPN was higher in FDRs with arthralgia (2.09 ng/ml±1.19) than in asymptomatics (1.70 ng/ml±0.55), also without significant difference. Pathologic findings by US7 were detected in 10/25 (40%) FDRs, of which three (12%) had arthralgia and seven (28%) were asymptomatic. Conclusions: The raised OPG and lower OPN in FDRs than in controls reflect an altered bone metabolism which could precede clinical disease phase. OPN and OPG could serve as markers of altered preclinical bone metabolism in FDRs of RA. US7 score might be a useful screening tool to identify ‘at-risk’ individuals.

scholarly journals Extramucosal formation and prognostic value of secretory antibodies in rheumatoid arthritis

2021 ◽  
Author(s):  
Klara Martinsson ◽  
Lovisa Lyttbacka Kling ◽  
Karin Roos Ljungberg ◽  
Irina Griazeva ◽  
Marina Samoylovich ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Prognostic Value ◽  
Secretory Antibodies
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