Blood clotting and traumatic injury with shock mediates complement-dependent neutrophil priming for extracellular ROS, ROS-dependent organ injury and coagulopathy

C. D. Barrett; A. T. Hsu; C. D. Ellson; B. Y.Miyazawa; Y.-W. Kong; J. D. Greenwood; S. Dhara; M. D. Neal; J. L. Sperry; M. S. Park; M. J. Cohen; B. S. Zuckerbraun; M. B. Yaffe

doi:10.1111/cei.13166

Blood clotting and traumatic injury with shock mediates complement-dependent neutrophil priming for extracellular ROS, ROS-dependent organ injury and coagulopathy

Clinical & Experimental Immunology ◽

10.1111/cei.13166 ◽

2018 ◽

Vol 194 (1) ◽

pp. 103-117 ◽

Cited By ~ 10

Author(s):

C. D. Barrett ◽

A. T. Hsu ◽

C. D. Ellson ◽

B. Y.Miyazawa ◽

Y.-W. Kong ◽

...

Keyword(s):

Blood Clotting ◽

Traumatic Injury ◽

Organ Injury ◽

Neutrophil Priming

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HEMODYNAMIC CHANGES IN PATIENTS TREATED FOR HYPOVOLEMIA

10.36106/ijar/0510841 ◽

2021 ◽

pp. 22-24

Author(s):

Udaykumar Jaihind Khasage ◽

Mahesh Krishnamurthy ◽

Ganesh BS ◽

Bharath Kempanna ◽

Mahesh Hatti

Keyword(s):

Emergency Department ◽

Traumatic Injury ◽

Femoral Fractures ◽

Organ Injury ◽

Abdominal Organ ◽

Hemodynamic Changes ◽

Traumatic Injuries ◽

Major Vessel ◽

The World ◽

Prospective Comparative Study

INTRODUCTION: Traumatic causes can result from penetrating and blunt trauma. Common traumatic injuries that can result in hemorrhagic shock include the following: myocardial laceration and rupture, major vessel laceration, solid abdominal organ injury, pelvic and femoral fractures, and scalp lacerations. Every individual in the world is at risk for traumatic injury. METHODOLOGY:The study was conducted in 50 patients and 50 controls who visited the Emergency Department. This is a prospective comparative study conducted in the adult Emergency Department. Heart rate w RESULTS: as more in the pre-uid resuscitation with a mean of 114.40 compared to the 100.30 in the post-uid resuscitation group Systolic blood pressure wa CONCLUSION: s lesser in the pre-uid resuscitation with a mean of 76.84 compared to the 101.08 in the post-uid resuscitation group

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The Abdominal Compartment Syndrome as a Second Insult During Systemic Neutrophil Priming Provokes Multiple Organ Injury

Shock ◽

10.1097/01.shk.0000082487.34705.d3 ◽

2003 ◽

Vol 20 (4) ◽

pp. 303-308 ◽

Cited By ~ 46

Author(s):

Joao B. Rezende-Neto ◽

Ernest E. Moore ◽

Tomohiko Masuno ◽

Peter K. Moore ◽

Jeffrey L. Johnson ◽

...

Keyword(s):

Compartment Syndrome ◽

Abdominal Compartment Syndrome ◽

Multiple Organ ◽

Organ Injury ◽

Multiple Organ Injury ◽

Abdominal Compartment ◽

Neutrophil Priming

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Right inferior phrenic artery injury as a complication of needle aspiration: a case report

The Cardiothoracic Surgeon ◽

10.1186/s43057-021-00045-4 ◽

2021 ◽

Vol 29 (1) ◽

Author(s):

Mohamed El Adel ◽

Sayed Hassan ◽

Mohamed A. Nady ◽

Ahmed Ghoneim ◽

Hany Seif

Keyword(s):

Traumatic Injury ◽

Needle Aspiration ◽

Endovascular Embolization ◽

Organ Injury ◽

Inferior Phrenic Artery ◽

Artery Injury ◽

Abdominal Bleeding ◽

Phrenic Artery ◽

The Right ◽

Dissection Technique

Abstract Background To the best of the author’s knowledge, inferior phrenic artery injury was not documented in the literature as a complication of chest tube insertion or needle aspiration, and our case was the first to be mentioned in literature. Traumatic injury to the inferior phrenic artery is extremely rare. It was reported to be injured by blunt trauma such as motorcar accident and may be associated with another organ injury. Case presentation The present case represents an unexpected event of inferior phrenic artery injury due to iatrogenic chest aspiration. Despite the safe maneuver we have approached in our center using a blunt dissection technique rather than the trocar technique, an unexpected complication occurred. The right inferior phrenic artery was injured with subsequent intra-abdominal bleeding and shock. It was treated successfully by endovascular embolization of the bleeding artery. Conclusions This complication might add a further morbidity and mortality and raising the responsibility of the surgeon to one of the most common daily surgeon’s practices.

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The host response to trauma and burns in the critically ill

10.1093/med/9780199600830.003.0304 ◽

2016 ◽

Author(s):

Edward A. Bittner ◽

Shawn P. Fagan

Keyword(s):

Inflammatory Response ◽

Host Response ◽

Expression Patterns ◽

Traumatic Injury ◽

Recovery Process ◽

Organ Injury ◽

Severe Injury ◽

Poor Correlation ◽

Severe Traumatic Injury ◽

Anti Inflammatory

Following severe traumatic injury, patients enter a state of immune dysregulation consisting of both exaggerated inflammation and immune suppression. Traditionally, the host response has been viewed as an early systemic inflammatory response syndrome (SIRS) followed temporally by a compensatory anti-inflammatory or immune-suppressive response syndrome (CARS). While this paradigm has been widely accepted across both medical and scientific fields, recent advances have challenged this concept. The Glue grant investigators recently characterized both the initial inflammatory response to injury and the dynamic evolving recovery process. They found: (1) severe injury produces a rapid (< 12 hours) genomic reprioritization in which 80% of the leukocyte transcriptome is altered; (2) similarities in gene expression patterns between different injuries reveal an apparently fundamental response to severe inflammatory stress, which is far more common than different; (3) alterations in the expression of classical inflammatory and anti-inflammatory as well as adaptive immunity genes occur simultaneously, not sequentially after severe injury; (4) the temporal nature of the current SIRS/CARS paradigm is not supported at the level of the leukocyte transcriptome. Complications are not associated with genomic evidence of a ‘second hit’ and differ only in the magnitude and duration of this genomic reprioritization. Furthermore, the delayed clinical recovery with organ injury is not associated with dramatic qualitative differences in the leukocyte transcriptome. Finally, poor correlation between human and rodent inflammatory genomic responses will alter how the host response is studied in the future.

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Update: Behavioral Management of Unilateral Vocal Fold Paralysis and Paresis

Perspectives of the ASHA Special Interest Groups ◽

10.1044/2019_pers-sig3-2018-0018 ◽

2019 ◽

Vol 4 (3) ◽

pp. 474-482

Author(s):

Sarah L. Schneider

Keyword(s):

Vocal Fold ◽

Treatment Plan ◽

Traumatic Injury ◽

Voice Therapy ◽

Valuable Insight ◽

Behavioral Management ◽

Use Patterns ◽

Vocal Quality ◽

And Function ◽

Voice Use

PurposeVocal fold motion impairment (VFMI) can be the result of iatrogenic or traumatic injury or may be idiopathic in nature. It can result in glottic incompetence leading to changes in vocal quality and ease. Associated voice complaints may include breathiness, roughness, diplophonia, reduced vocal intensity, feeling out of breath with talking, and vocal fatigue with voice use. A comprehensive interprofessional voice evaluation includes auditory-perceptual voice evaluation, laryngeal examination including videostroboscopy, acoustic and aerodynamic voice measures. These components provide valuable insight into laryngeal structure and function and individual voice use patterns and, in conjunction with stimulability testing, help identify candidacy for voice therapy and choice of therapeutic techniques.ConclusionA comprehensive, interprofessional evaluation of patients with VFMI is necessary to assess the role of voice therapy and develop a treatment plan. Although there is no efficacy data to support specific voice therapy techniques for treating VFMI, considerations for various techniques are provided.

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