scholarly journals Regulatory T cells: tolerance induction in solid organ transplantation

2017 ◽  
Vol 189 (2) ◽  
pp. 197-210 ◽  
Author(s):  
T. Vaikunthanathan ◽  
N. Safinia ◽  
D. Boardman ◽  
R. I. Lechler ◽  
G. Lombardi
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Organ Transplantation ◽  
Solid Organ Transplantation ◽  
Tolerance Induction ◽  
Solid Organ

Low-dose of tacrolimus favors the induction of functional CD4+CD25+FoxP3+ regulatory T cells in solid-organ transplantation

2009 ◽  
Vol 9 (5) ◽  
pp. 564-569 ◽  
Author(s):  
Zhen Wang ◽  
Bingyi Shi ◽  
Hailong Jin ◽  
Li Xiao ◽  
Yongwei Chen ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Organ Transplantation ◽  
Low Dose ◽  
Solid Organ Transplantation ◽  
Solid Organ

scholarly journals Regulatory T Cells and Kidney Transplantation

2018 ◽  
Vol 13 (11) ◽  
pp. 1760-1764 ◽  
Author(s):  
Paloma Leticia Martin-Moreno ◽  
Sudipta Tripathi ◽  
Anil Chandraker
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Organ Transplantation ◽  
Tissue Repair ◽  
Solid Organ Transplantation ◽  
Immunosuppressive Drugs ◽  
Solid Organ ◽  
Effective Expansion ◽  
Conventional Immunosuppression

The ability of the immune system to differentiate self from nonself is critical in determining the immune response to antigens expressed on transplanted tissue. Even with conventional immunosuppression, acceptance of the allograft is an active process often determined by the presence of regulatory T cells (Tregs). Tregs classically are CD4+ cells that constitutively express high levels of the IL-2 receptor α chain CD25, along with the transcription factor Foxp3. The use of Tregs in the field of solid organ transplantation is related specifically to the objective of achieving tolerance, with the goal of reducing or eliminating immunosuppressive drugs as well as maintaining tissue repair and managing acute rejection. A key issue in clinical use of Tregs is how to effectively expand the number of Tregs, either through increasing numbers of endogenous Tregs or by the direct infusion of exogenously expanded Tregs. In order to realize the benefits of Treg therapy in solid organ transplantation, a number of outstanding challenges need to be overcome, including assuring an effective expansion of Tregs, improving long-term Treg stability and reduction of risk-related to off-target, nonspecific, immunosuppressive effects related specially to cancer.

Donor-specific regulatory T cells might be used to induce tolerance in solid organ transplantation

2008 ◽  
Vol 71 (4) ◽  
pp. 602-604
Author(s):  
Yuchuan Huang ◽  
Jinjing Wang ◽  
Chuntao Zhang ◽  
Jun Shan ◽  
Shujuan Yang ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Organ Transplantation ◽  
Solid Organ Transplantation ◽  
Solid Organ

scholarly journals Regulatory T cells: first steps of clinical application in solid organ transplantation

2015 ◽  
Vol 29 (1) ◽  
pp. 3-11 ◽  
Author(s):  
Jeroen B. van der Net ◽  
Andrew Bushell ◽  
Kathryn J. Wood ◽  
Paul N. Harden
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Organ Transplantation ◽  
Clinical Application ◽  
Solid Organ Transplantation ◽  
Solid Organ

Heterogeneity in the Suppressive Activity of Human Regulatory T Cells - Relevance for Solid Organ Transplantation?

2012 ◽  
Vol 94 (10S) ◽  
pp. 438
Author(s):  
E. M. Aandahl ◽  
M. Hagness ◽  
K. Henjum ◽  
A. Foss ◽  
K. W. Brudvik ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Organ Transplantation ◽  
Solid Organ Transplantation ◽  
Solid Organ ◽  
Suppressive Activity
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