scholarly journals Advantage of tacrolimus/mycophenolate mofetil regimen for cytotoxic T cell-mediated defence and its inhibition by additive steroid administration in high-risk liver transplant recipients

2016 ◽  
Vol 184 (1) ◽  
pp. 126-136
Author(s):  
S. Uemoto ◽  
K. Ozawa ◽  
T. Kaido ◽  
A. Mori ◽  
Y. Fujimoto
Keyword(s):  
Mycophenolate Mofetil ◽  
T Cell ◽  
High Risk ◽  
Liver Transplant ◽  
Cytotoxic T Cell ◽  
Transplant Recipients ◽  
Steroid Administration ◽  
Liver Transplant Recipients

scholarly journals Cytotoxic T-cell-mediated defense against infections in human liver transplant recipients

2007 ◽  
Vol 13 (2) ◽  
pp. 287-293 ◽  
Author(s):  
Koichi Tanaka ◽  
Shinji Uemoto ◽  
Hiroto Egawa ◽  
Yasutsugu Takada ◽  
Kazue Ozawa ◽  
...  
Keyword(s):  
T Cell ◽  
Liver Transplant ◽  
Human Liver ◽  
Cytotoxic T Cell ◽  
Transplant Recipients ◽  
Liver Transplant Recipients

scholarly journals Prospective Assessment of Cytomegalovirus Immunity in High-Risk Donor-Seropositive/Recipient-Seronegative Liver Transplant Recipients Receiving Either Preemptive Therapy or Antiviral Prophylaxis

2019 ◽  
Vol 220 (5) ◽  
pp. 752-760 ◽  
Author(s):  
Ajit P Limaye ◽  
Margaret L Green ◽  
Bradley C Edmison ◽  
Terry Stevens-Ayers ◽  
Sam Chatterton-Kirchmeier ◽  
...  
Keyword(s):  
T Cell ◽  
High Risk ◽  
Liver Transplant ◽  
Late Onset ◽  
T Cell Responses ◽  
Preemptive Therapy ◽  
Antiviral Prophylaxis ◽  
Transplant Recipients ◽  
Cell Responses ◽  
Liver Transplant Recipients

Abstract The differential impact of preemptive therapy (PET) and antiviral prophylaxis (AP) on development of cytomegalovirus (CMV)–specific neutralizing antibody (nAb) and T-cell responses have not previously been directly compared in high-risk donor-seropositive/recipient-seronegative (D+R−) organ transplant recipients. We prospectively assessed T-cell and nAb responses 3 months after transplantation in cohorts of high-risk D+R− liver transplant recipients who received either PET (n = 15) or AP (n = 25) and a control group of CMV-seropositive transplant recipients (R+) (AP; n = 24). CMV phosphoprotein 65 (pp65)– and immediate early protein 1–specific multifunctional T-cell responses were determined by means of intracellular cytokine staining and nAbs against BADrUL131-Y4 CMV in adult retinal pigment epithelial cell line-19 human epithelial cells; nAbs were detected in 8 of 12 (67%) in the PET group, none of 17 in the AP group, and 20 of 22 (91%) in the R+ group. Multifunctional CD8 and CD4 T-cell responses to pp65 were generally similar between PET and R+ groups, and lower for the AP group; multifunctional CD4 responses were similar across all groups. Among D+R− liver transplant recipients, PET was associated with the development of greater nAb and multifunctional CD8 T-cell responses compared with AP, providing a potential mechanism to explain the relative protection against late-onset disease with PET. Future studies are needed to define specific immune parameters predictive of late-onset CMV disease with AP.

Comparison between kidney and liver transplant recipients admitted to a referral center regarding coronavirus-2019 manifestations in the Northeast of Iran during three peaks of pandemic

2021 ◽  
Vol 17 ◽  
Author(s):  
Mohsen Aliakbarian ◽  
Rozita Khodashahi ◽  
Mahin Ghorban Sabbagh ◽  
Hamid Reza Naderi ◽  
Mandana Khodashahi ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
High Risk ◽  
Liver Transplant ◽  
Severe Infection ◽  
Clinical Findings ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Cross Sectional ◽  
Significant Difference ◽  
Liver Transplant Recipients

Background: Transplant recipients are at high risk for severe Coronavirus disease-2019 (COVID-19). Transplant recipients are immune-compromised individuals at high risk for severe infection. This study aimed to compare the presentations and outcomes of liver and kidney transplant recipients who were infected with COVID-19 in the Iranian population. Methods: This cross-sectional study was conducted at Imam Reza and Montaserieh Hospitals affiliated with Mashhad University of Medical Sciences, Mashhad, Iran, between 2020 and 2021. In general, 52 patients were selected and divided into two groups of the kidney (n=28) and liver (n=24) transplantation. Two groups were compared in terms of demographic characteristics and clinical findings. Results: Of 52 patients, severe COVID-19 infection was reported in 61% of the patients. There was no significant difference between the two groups in terms of symptoms, except for cough (χ2=8.09; P=0.004), clinical condition, and laboratory symptoms, except for creatinine (Z=14; P<0.005), alkaline phosphatase (Z=4.55; P=0.03), total bilirubin (Z=8.93; P=0.03), and partial thromboplastin time (Z=5.97; P=0.01). There was no relationship between the outcome and the use of immunosuppressive medications (P>0.05). All patients with kidney transplantation survived, while two cases in the liver transplantation group failed to survive (χ2=2.42; P=0.11). Conclusion: The mortality rate was higher in the liver transplant recipients, compared to the patients who underwent kidney transplantation.

Differential profile of activated regulatory T cell subsets and microRNAs in tolerant liver transplant recipients

2017 ◽  
Vol 23 (7) ◽  
pp. 933-945 ◽  
Author(s):  
Beatriz Revilla-Nuin ◽  
África de Bejar ◽  
Laura Martínez-Alarcón ◽  
José Ignacio Herrero ◽  
Carlos Manuel Martínez-Cáceres ◽  
...  
Keyword(s):  
T Cell ◽  
Liver Transplant ◽  
Regulatory T Cell ◽  
T Cell Subsets ◽  
Transplant Recipients ◽  
Liver Transplant Recipients
Sign in / Sign up

Export Citation Format

Share Document