scholarly journals The ageing human B cell repertoire: a failure of selection?

2015 ◽  
Vol 183 (1) ◽  
pp. 50-56 ◽  
Author(s):  
D. K. Dunn-Walters
Keyword(s):  
B Cell ◽  
Cell Repertoire ◽  
B Cell Repertoire ◽  
Human B Cell

scholarly journals When designing vaccines, consider the starting material: the human B cell repertoire

2018 ◽  
Vol 53 ◽  
pp. 209-216 ◽  
Author(s):  
Colin Havenar-Daughton ◽  
Robert K. Abbott ◽  
William R. Schief ◽  
Shane Crotty
Keyword(s):  
B Cell ◽  
Starting Material ◽  
Cell Repertoire ◽  
B Cell Repertoire ◽  
Human B Cell

Fas-dependent and Fas-independent Mechanisms for Selection of the Mature Human B Cell Repertoire

1997 ◽  
Vol 815 (1 B-Lymphocytes) ◽  
pp. 67-73 ◽  
Author(s):  
THIERRY DEFRANCE ◽  
GISÈLE BILLIAN ◽  
PETER H. KRAMMER ◽  
CHANTAL LAGRESLE
Keyword(s):  
B Cell ◽  
Cell Repertoire ◽  
B Cell Repertoire ◽  
Human B Cell ◽  
Selection Of

scholarly journals Functionally Convergent B Cell Receptor Sequences in Transgenic Rats Expressing a Human B Cell Repertoire in Response to Tetanus Toxoid and Measles Antigens

2017 ◽  
Vol 8 ◽  
Author(s):  
Jean-Philippe Bürckert ◽  
Axel R. S. X. Dubois ◽  
William J. Faison ◽  
Sophie Farinelle ◽  
Emilie Charpentier ◽  
...  
Keyword(s):  
B Cell ◽  
Tetanus Toxoid ◽  
Cell Receptor ◽  
B Cell Receptor ◽  
Transgenic Rats ◽  
Cell Repertoire ◽  
B Cell Repertoire ◽  
Human B Cell

scholarly journals Clonal Analysis of the Human B-Cell Repertoire Using a Heteromobility Assay

2000 ◽  
Vol 7 (3) ◽  
pp. 507-509 ◽  
Author(s):  
Deepanker Tewari
Keyword(s):  
B Cells ◽  
Genetic Variability ◽  
B Cell ◽  
Clonal Analysis ◽  
Dna Probe ◽  
Cell Repertoire ◽  
B Cell Repertoire ◽  
Cell Clonality ◽  
Human B Cell

ABSTRACT A heteromobility duplex tracking assay was developed to analyze B-cell clonality. The assay was based on the genetic variability of B-cell immunoglobulin (Ig) sequences. Binding of amplified (Ig) sequences to a single-stranded radiolabeled Ig DNA probe resulted in the formation of heteroduplexes. The mobilities of these heteroduplexes helped to distinguish clonal B cells.

V(D)J recombinatorial repertoire diversification during intraclonal pro-B to B-cell differentiation

Blood ◽  
2003 ◽  
Vol 101 (3) ◽  
pp. 1030-1037 ◽  
Author(s):  
Yui-Hsi Wang ◽  
Zhixin Zhang ◽  
Peter D. Burrows ◽  
Hiromi Kubagawa ◽  
S. Louis Bridges ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
B Cell ◽  
Cellular Proliferation ◽  
Gene Segment ◽  
Leukemic Cell ◽  
B Cell Differentiation ◽  
Leukemic Cell Line ◽  
Cell Repertoire ◽  
B Cell Repertoire ◽  
Human B Cell

Abstract The initial B-cell repertoire is generated by combinatorial immunoglobulin V(D)J gene segment rearrangements that occur in a preferential sequence. Because cellular proliferation occurs during the course of these rearrangement events, it has been proposed that intraclonal diversification occurs during this phase of B-cell development. An opportunity to examine this hypothesis directly was provided by the identification of a human acute lymphoblastic leukemic cell line that undergoes spontaneous differentiation from pro-B cell to the pre-B and B-cell stages with concomitant changes in the gene expression profile that normally occur during B-cell differentiation. After confirming the clonality of the progressively differentiating cells, an analysis of immunoglobulin genes and transcripts indicated that pro-B cell members marked by the same DJ rearrangement generated daughter B cells with multiple VH and VL gene segment rearrangements. These findings validate the principle of intraclonal V(D)J diversification during B-cell generation and define a manipulable model of human B-cell differentiation.

VH-Gene Representation in Autoantibodies Reflects the Normal Human B-Cell Repertoire

1992 ◽  
Vol 128 (1) ◽  
pp. 101-122 ◽  
Author(s):  
A. K. Stewart ◽  
C. Huang ◽  
A. A. Long ◽  
B. D. Stollar ◽  
R. S. Schwartz
Keyword(s):  
B Cell ◽  
Cell Repertoire ◽  
B Cell Repertoire ◽  
Normal Human ◽  
Vh Gene ◽  
Human B Cell

scholarly journals Vaccination-induced changes in human B-cell repertoire and pneumococcal IgM and IgA antibody at different ages

Aging Cell ◽  
2011 ◽  
Vol 10 (6) ◽  
pp. 922-930 ◽  
Author(s):  
Alexander Ademokun ◽  
Yu-Chang Wu ◽  
Victoria Martin ◽  
Rajive Mitra ◽  
Ulrich Sack ◽  
...  
Keyword(s):  
B Cell ◽  
Cell Repertoire ◽  
B Cell Repertoire ◽  
Different Ages ◽  
Iga Antibody ◽  
Induced Changes ◽  
Human B Cell
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