scholarly journals Multi‐parametric flow cytometric and genetic investigation of the peripheral B cell compartment in human type 1 diabetes

2014 ◽  
Vol 177 (3) ◽  
pp. 571-585 ◽  
Author(s):  
W. S. Thompson ◽  
M. L. Pekalski ◽  
H. Z. Simons ◽  
D. J. Smyth ◽  
X. Castro‐Dopico ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
B Cell ◽  
Genetic Investigation ◽  
Cell Compartment ◽  
Human Type ◽  
Flow Cytometric ◽  
Human Type 1 Diabetes

scholarly journals Uncoupling of Proliferation and Cytokines From Suppression Within the CD4+CD25+Foxp3+ T-Cell Compartment in the 1st Year of Human Type 1 Diabetes

Diabetes ◽  
2011 ◽  
Vol 60 (8) ◽  
pp. 2125-2133 ◽  
Author(s):  
A. Hughson ◽  
I. Bromberg ◽  
B. Johnson ◽  
S. Quataert ◽  
N. Jospe ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
Cell Compartment ◽  
Human Type ◽  
Human Type 1 Diabetes

Relationship between T and B Cell Responses to Proinsulin in Human Type 1 Diabetes

2003 ◽  
Vol 1005 (1) ◽  
pp. 288-294 ◽  
Author(s):  
IVANA DURINOVIC-BELLÓ ◽  
NICOLA MAISEL ◽  
MICHAEL SCHLOSSER ◽  
HUBERT KALBACHER ◽  
MARTIN DEEG ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
B Cell ◽  
Cell Responses ◽  
Human Type ◽  
B Cell Responses ◽  
Human Type 1 Diabetes

scholarly journals Peripheral autoreactive CD8 T‐cell frequencies are too variable to be a reliable predictor of disease progression of human type 1 diabetes

2021 ◽  
Vol 10 (7) ◽  
Author(s):  
Johnna D Wesley ◽  
Susanne Pfeiffer ◽  
Darius Schneider ◽  
David Friedrich ◽  
Nikole Perdue ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
Disease Progression ◽  
Cd8 T Cell ◽  
Human Type ◽  
Reliable Predictor ◽  
Human Type 1 Diabetes

scholarly journals Deciphering the Pathogenesis of Human Type 1 Diabetes (T1D) by Interrogating T Cells from the “Scene of the Crime”

2017 ◽  
Vol 17 (10) ◽  
Author(s):  
Sally C. Kent ◽  
Stuart I. Mannering ◽  
Aaron W. Michels ◽  
Jenny Aurielle B. Babon
Keyword(s):  
T Cells ◽  
Type 1 Diabetes ◽  
Human Type ◽  
Human Type 1 Diabetes

scholarly journals Proinsulin peptide promotes autoimmune diabetes in a novel HLA-DR3-DQ2-transgenic murine model of spontaneous disease

Diabetologia ◽  
2019 ◽  
Vol 62 (12) ◽  
pp. 2252-2261 ◽  
Author(s):  
Johan Verhagen ◽  
Norkhairin Yusuf ◽  
Emma L. Smith ◽  
Emily M. Whettlock ◽  
Kerina Naran ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Autoimmune Diabetes ◽  
Diabetes Incidence ◽  
Human Type ◽  
Insulin Promoter ◽  
Human Type 1 Diabetes ◽  
Hla Dr3 ◽  
Peptide Region

Abstract Aims/hypothesis The molecular basis for the pathological impact of specific HLA molecules on autoimmune diseases such as type 1 diabetes remains unclear. Recent natural history studies in children have indicated a link between specific HLA genotypes and the first antigenic target against which immune responses develop. We set out to examine this link in vivo by exploring the diabetogenicity of islet antigens on the background of a common diabetes-associated HLA haplotype. Methods We generated a novel HLA-transgenic mouse model that expresses high-risk genes for type 1 diabetes (DRB1*03:01-DQA1*05:01-DQB1*02:01) as well as human CD80 under the rat insulin promoter and human CD4, on a C57BL/6 background. Adjuvanted antigen priming was used to reveal the diabetogenicity of candidate antigens and peptides. Results HLA-DR3-DQ2+huCD4+IA/IE−/−RIP.B7.1+ mice spontaneously developed autoimmune diabetes (incidence 46% by 35 weeks of age), accompanied by numerous hallmarks of human type 1 diabetes (autoantibodies against GAD65 and proinsulin; pancreatic islet infiltration by CD4+, CD8+ B220+, CD11b+ and CD11c+ immune cells). Disease was markedly accelerated and had deeper penetrance after adjuvanted antigen priming with proinsulin (mean onset 11 weeks and incidence 100% by 20 weeks post challenge). Moreover, the diabetogenic effect of proinsulin located to the 15-residue B29-C11 region. Conclusions/interpretation Our study identifies a proinsulin-derived peptide region that is highly diabetogenic on the HLA-DR3-DQ2 background using an in vivo model. This approach and the peptide region identified may have wider implications for future studies of human type 1 diabetes.

scholarly journals Low-Dose Otelixizumab Anti-CD3 Monoclonal Antibody DEFEND-1 Study: Results of the Randomized Phase III Study in Recent-Onset Human Type 1 Diabetes

Diabetes Care ◽  
2014 ◽  
Vol 37 (10) ◽  
pp. 2746-2754 ◽  
Author(s):  
Ronnie Aronson ◽  
Peter A. Gottlieb ◽  
Jens S. Christiansen ◽  
Thomas W. Donner ◽  
Emanuele Bosi ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Type 1 Diabetes ◽  
Low Dose ◽  
Phase Iii ◽  
Recent Onset ◽  
Human Type ◽  
Study Results ◽  
Phase Iii Study ◽  
Human Type 1 Diabetes
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