scholarly journals Blunted expression of miR-199a-5p in regulatory T cells of patients with chronic obstructive pulmonary disease compared to unaffected smokers

2014 ◽  
Vol 177 (1) ◽  
pp. 341-352 ◽  
Author(s):  
W. M. Chatila ◽  
G. J. Criner ◽  
W. W. Hancock ◽  
T. Akimova ◽  
B. Moldover ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
T Cells ◽  
Regulatory T Cells ◽  
Pulmonary Disease ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease

Regulation in chronic obstructive pulmonary disease: the role of regulatory T-cells and Th17 cells

2010 ◽  
Vol 119 (2) ◽  
pp. 75-86 ◽  
Author(s):  
Nina Lane ◽  
R. Adrian Robins ◽  
Jonathan Corne ◽  
Lucy Fairclough
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
T Cells ◽  
Regulatory T Cells ◽  
Pulmonary Disease ◽  
Disease Process ◽  
Aetiological Factor ◽  
Chronic Obstructive ◽  
Inflammatory Disorder ◽  
Obstructive Pulmonary Disease

COPD (chronic obstructive pulmonary disease) is an inflammatory disorder of the airways, which is associated with irreversible airway obstruction. The pathological hallmarks of COPD are destruction of the lung parenchyma (pulmonary emphysema), inflammation of the central airways (chronic bronchitis) and inflammation of the peripheral airways (respiratory bronchiolitis). Tobacco smoking is established as the main aetiological factor for COPD. A maladaptive modulation of inflammatory responses to inhalation of noxious particles and gases is generally accepted as being a key central pathogenic process; however, the precise regulatory mechanisms of the disease are poorly understood. Two cell types are known to be important in immune regulation, namely regulatory T-cells and the newly identified Th17 (T-helper 17) cells. Both types of cells are subsets of CD4 T-lymphocytes and modulate the immune response through secretion of cytokines, for example IL (interleukin)-10 and IL-17 respectively. The present review will begin by describing the current understanding of inflammatory cell involvement in the disease process, and then focus on the possible role of subsets of regulatory and helper T-cells in COPD.

Impaired function of regulatory T-cells in patients with chronic obstructive pulmonary disease (COPD)

Immunobiology ◽  
2014 ◽  
Vol 219 (12) ◽  
pp. 975-979 ◽  
Author(s):  
Dino B.A. Tan ◽  
Sonia Fernandez ◽  
Patricia Price ◽  
Martyn A. French ◽  
Philip J. Thompson ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
T Cells ◽  
Regulatory T Cells ◽  
Pulmonary Disease ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Impaired Function
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