scholarly journals Involvement of autoimmunity to REG , a regeneration factor, in patients with primary S jögren's syndrome

2013 ◽  
Vol 174 (1) ◽  
pp. 1-9 ◽  
Author(s):  
K. Yoshimoto ◽  
T. Fujimoto ◽  
A. Itaya‐Hironaka ◽  
T. Miyaoka ◽  
S. Sakuramoto‐Tsuchida ◽  
...  
Keyword(s):  
Regeneration Factor

Autoantibodies to REG, a beta-cell regeneration factor, in diabetic patients

2004 ◽  
Vol 34 (11) ◽  
pp. 752-758 ◽  
Author(s):  
N. J. Shervani ◽  
S. Takasawa ◽  
Y. Uchigata ◽  
T. Akiyama ◽  
K. Nakagawa ◽  
...  
Keyword(s):  
Beta Cell ◽  
Diabetic Patients ◽  
Cell Regeneration ◽  
Beta Cell Regeneration ◽  
Regeneration Factor

Variable Helix Cutter Design to Suppress Regenerative Effect

2019 ◽  
Author(s):  
Norikazu Suzuki ◽  
Rikiya Ishiguro ◽  
Tomoki Morita ◽  
Eiji Shamoto
Keyword(s):  
Design Methodology ◽  
Design Method ◽  
Simultaneous Optimization ◽  
Axial Position ◽  
Depth Of Cut ◽  
Chatter Vibration ◽  
Major Mechanism ◽  
Variable Helix ◽  
Cutter Design ◽  
Regeneration Factor

Abstract Regeneration is a major mechanism to generate self-excited chatter vibration in cutting. Variable helix cutters are useful to suppress regeneration. Although simultaneous optimization of pitch/helix angles is significantly important, there is no practical design methodology to optimize the variable helix cutter geometry so far. In order to attain robust regeneration suppression, a new design method of variable helix cutters is proposed in the present study. The pitch angles vary along axial position due to disagreement of the helix angles. Because of this nature, regeneration can be suppressed in a robust manner with respect to changes of chatter frequency and/or spindle speed. The proposed design satisfies robustness against axial depth of cut variations. Optimal pitch/helix angles are formulated on the basis of distinctive relationship between the cutter geometry and “Regeneration Factor (RF)”, which is an index to quantify influence of regeneration in the process. Through analytical investigations, it is confirmed that regeneration can be suppressed effectively by the proposed method, resulting in significant chatter stability increase. Low immersion milling experiment verified significant stability and robustness of the proposed variable helix design.

scholarly journals Effects of plant-derived immunomodulators and lizak preparation in vitro taken separately or in combination on the immune factors of palatine tonsils of children with chronic tonsillitis

2020 ◽  
pp. 13-18
Author(s):  
Alexander Yu. Bredun ◽  
Oleg F. Melnikov ◽  
Мarina D. Timchenko
Keyword(s):  
Growth Factor ◽  
Cell Viability ◽  
Tissue Regeneration ◽  
Transforming Growth Factor ◽  
Interferon Γ ◽  
Interleukin 1Β ◽  
Combined Use ◽  
Antibacterial Preparation ◽  
Regeneration Factor

Introduction: Chronic inflammatory diseases of the upper respiratory tract of both microbial and viral origin occur due to the immune deficiency of systemic and local nature. Among a large number of immunomodulation agents, a special role belongs to plant preparations, which are characterized by relative harmlessness and high efficiency, both in case of systemic and local use and they are often combined with antimicrobial agents, therefore the aim of the study was to investigate their effect on the reactions and condition of lymphoid cells of tonsilswith separate and combined use in vitro. Methods: Cell suspensions were prepared mechanically and adjusted to a concentration of 2 million/ml in medium 199 with additives. Then, Lizak preparation was added to the cells and starch solution was used in control. Imupret and Esberitox preparations were added to the culture with or without Lizak preparation. After cultivation, the levels of proinflammatory cytokine – Interleukin-1β, pro-allergic factor – Interleukin-4, Th-1 – derivative of cytokine – interferon-γ were studied in the supernatant using the «Tsitokin LLC» reagent kits (RF), as well as tissue regeneration factor – transforming growth factor –TGF-1β (Austria). The preparation was prepared from the cell pellet, in which the relative nonviable cell count was determined in a sample with trypan blue using a light microscope (Olympus CX21FS1).The statistical analysis was performed using Student's t-distribution. Results: Plant-derived preparations did not have any effect on cell viability in culture, did not reduce the level of the pro-inflammatory cytokine interleukin-1β and did not stimulate the production of the regeneration factor TGF-1β. At the same time, the combined use of plant-derived preparations and the antibacterial preparation Lizak in cell culture of tonsils was accompanied by an increase in cell viability compared to the use of Lizak preparation separately, the stimulation of the regulatory antiviral factor interferon-γ and an increase in the production of tissue regeneration factor. Conclusion: The immunomodulating properties of the antibacterial preparation Lizak and plant-derived immunomodulator Esberitox significantly differ in the points of application. Both plant-derived preparations stimulated the production of γ-interferon by tonsil cells in the presence of Lizak preparation, the transforming growth factor TGF-1β, the viability of tonsil cells was the highest with the combination of Lizak and Esberitox.

scholarly journals Identification of a Receptor for Reg (Regenerating Gene) Protein, a Pancreatic β-Cell Regeneration Factor

2000 ◽  
Vol 275 (15) ◽  
pp. 10723-10726 ◽  
Author(s):  
Seiichi Kobayashi ◽  
Takako Akiyama ◽  
Koji Nata ◽  
Michiaki Abe ◽  
Minori Tajima ◽  
...  
Keyword(s):  
Protein A ◽  
Cell Regeneration ◽  
Pancreatic Β Cell ◽  
Β Cell ◽  
Regeneration Factor

scholarly journals Classifying Patterns of Understory Vegetation in Mixed-Oak Forests in Two Ecoregions of Pennsylvania

2008 ◽  
Vol 25 (1) ◽  
pp. 38-44 ◽  
Author(s):  
Melanie J. Kaeser ◽  
Peter J. Gould ◽  
Marc E. McDill ◽  
Kim C. Steiner ◽  
James C. Finley
Keyword(s):  
Plant Species ◽  
Ground Cover ◽  
Tree Regeneration ◽  
Understory Vegetation ◽  
Advance Regeneration ◽  
Species Groups ◽  
Allegheny Plateau ◽  
And Cluster Analysis ◽  
Composite Variables ◽  
Regeneration Factor

Abstract Understory plots in mixed-oak stands in the Ridge and Valley and Allegheny Plateau ecoregions of Pennsylvania were classified to summarize the range of understory conditions common to the region and to evaluate relationships between understory vegetation, overstory conditions, and advance tree regeneration. Factor analysis and cluster analysis were used to identify understory classes. Vegetation cover data including 15 variables (plant species, bare ground, and rocky ground cover) and 4 composite variables (plant species groups) were observed on 1,208 204-m2 plots.The eight vegetation classes resulting from the analyses were associated with different overstory compositions and advance regeneration densities. The understory classes identified in this study may provide insight on the distribution and diversity of problematic and nonproblematic vegetation types.

Effect of nerve regeneration factor on differentiation of PC12 cells and its signaling pathway*

2004 ◽  
Vol 14 (11) ◽  
pp. 971-974 ◽  
Author(s):  
Fei Ding ◽  
Liang Qiang ◽  
Mei Liu ◽  
Xingxing Gu ◽  
Xiaosong Gu
Keyword(s):  
Nerve Regeneration ◽  
Signaling Pathway ◽  
Pc12 Cells ◽  
Regeneration Factor
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