scholarly journals Thymus transplantation restores the repertoires of forkhead box protein 3 (FoxP3)+and FoxP3−T cells in complete DiGeorge anomaly

2013 ◽  
Vol 173 (1) ◽  
pp. 140-149 ◽  
Author(s):  
I. K. Chinn ◽  
J. D. Milner ◽  
P. Scheinberg ◽  
D. C. Douek ◽  
M. L. Markert
Keyword(s):  
T Cells ◽  
Forkhead Box ◽  
Thymus Transplantation ◽  
Digeorge Anomaly

Thymus Transplantation Restores the Repertoire of Foxp3+ T Cells in Complete DiGeorge Anomaly

2013 ◽  
Vol 131 (2) ◽  
pp. AB196
Author(s):  
Ivan Chinn ◽  
Joshua D. Milner ◽  
Phillip Scheinberg ◽  
Daniel Douek ◽  
M. Louise Markert
Keyword(s):  
T Cells ◽  
Thymus Transplantation ◽  
Digeorge Anomaly

scholarly journals TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo

2010 ◽  
Vol 207 (8) ◽  
pp. 1701-1711 ◽  
Author(s):  
Rachel A. Gottschalk ◽  
Emily Corse ◽  
James P. Allison
Keyword(s):  
T Cells ◽  
Time Course ◽  
Low Dose ◽  
Cell Receptor ◽  
Peripheral Tolerance ◽  
Ligand Density ◽  
Forkhead Box ◽  
Histocompatibility Complex ◽  
Maximal Induction

T cell receptor (TCR) ligation is required for the extrathymic differentiation of forkhead box p3+ (Foxp3+) regulatory T cells. Several lines of evidence indicate that weak TCR stimulation favors induction of Foxp3 in the periphery; however, it remains to be determined how TCR ligand potency influences this process. We characterized the density and affinity of TCR ligand favorable for Foxp3 induction and found that a low dose of a strong agonist resulted in maximal induction of Foxp3 in vivo. Initial Foxp3 induction by weak agonist peptide could be enhanced by disruption of TCR–peptide major histocompatibility complex (pMHC) interactions or alteration of peptide dose. However, time course experiments revealed that Foxp3-positive cells induced by weak agonist stimulation are deleted, along with their Foxp3-negative counterparts, whereas Foxp3-positive cells induced by low doses of the strong agonist persist. Our results suggest that, together, pMHC ligand potency, density, and duration of TCR interactions define a cumulative quantity of TCR stimulation that determines initial peripheral Foxp3 induction. However, in the persistence of induced Foxp3+ T cells, TCR ligand potency and density are noninterchangeable factors that influence the route to peripheral tolerance.

scholarly journals Forkhead box protein 3+regulatory T cells and Helios+subset in perinatally acquired HIV

2015 ◽  
Vol 180 (1) ◽  
pp. 108-117 ◽  
Author(s):  
G. Degaffe ◽  
R. Zakhour ◽  
W. Zhang ◽  
G. A. Contreras ◽  
C. S. Bell ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Forkhead Box ◽  
Perinatally Acquired

Point mutants of forkhead box P3 that cause immune dysregulation, polyendocrinopathy, enteropathy, X-linked have diverse abilities to reprogram T cells into regulatory T cells

2010 ◽  
Vol 126 (6) ◽  
pp. 1242-1251 ◽  
Author(s):  
Alicia N. McMurchy ◽  
Jana Gillies ◽  
Sarah E. Allan ◽  
Laura Passerini ◽  
Eleonora Gambineri ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Immune Dysregulation ◽  
Forkhead Box P3 ◽  
Forkhead Box
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