scholarly journals Changes in B cell immunophenotype in common variable immunodeficiency: cause or effect - is bronchiectasis indicative of undiagnosed immunodeficiency?

2013 ◽  
Vol 171 (2) ◽  
pp. 195-200 ◽  
Author(s):  
P. Bright ◽  
S. Grigoriadou ◽  
P. Kamperidis ◽  
M. Buckland ◽  
A. Hickey ◽  
...  
Keyword(s):  
B Cell ◽  
Common Variable Immunodeficiency ◽  
Common Variable

T and B lymphocyte abnormalities in bone marrow biopsies of common variable immunodeficiency

Blood ◽  
2011 ◽  
Vol 118 (2) ◽  
pp. 309-318 ◽  
Author(s):  
Manuella L. Gomes Ochtrop ◽  
Sigune Goldacker ◽  
Annette M. May ◽  
Marta Rizzi ◽  
Ruth Draeger ◽  
...  
Keyword(s):  
Bone Marrow ◽  
T Cell ◽  
B Cell ◽  
Common Variable Immunodeficiency ◽  
Plasma Cells ◽  
Cell Development ◽  
B Cell Development ◽  
Bone Marrow Biopsies ◽  
Cell Counts ◽  
Common Variable

Abstract In common variable immunodeficiency (CVID) defects in early stages of B-cell development, bone marrow (BM) plasma cells and T lymphocytes have not been studied systematically. Here we report the first morphologic and flow cytometric study of B- and T-cell populations in CVID BM biopsies and aspirates. Whereas the hematopoietic compartment showed no major lineage abnormalities, analysis of the lymphoid compartment exhibited major pathologic alterations. In 94% of the patients, BM plasma cells were either absent or significantly reduced and correlated with serum immunoglobulin G levels. Biopsies from CVID patients had significantly more diffuse and nodular CD3+ T lymphocyte infiltrates than biopsies from controls. These infiltrates correlated with autoimmune cytopenia but not with other clinical symptoms or with disease duration and peripheral B-cell counts. Nodular T-cell infiltrates correlated significantly with circulating CD4+CD45R0+ memory T cells, elevated soluble IL2-receptor and neopterin serum levels indicating an activated T-cell compartment in most patients. Nine of 25 patients had a partial block in B-cell development at the pre-B-I to pre-B-II stage. Because the developmental block correlates with lower transitional and mature B-cell counts in the periphery, we propose that these patients might form a new subgroup of CVID patients.

Abnormal response to a human B cell growth factor in patients with common variable immunodeficiency (CVI)

1991 ◽  
Vol 87 (6) ◽  
pp. 1138-1149 ◽  
Author(s):  
Julian L. Ambrus ◽  
Susan Haneiwich ◽  
Laura Chesky ◽  
Patrick McFarland ◽  
Marion G. Peters ◽  
...  
Keyword(s):  
Growth Factor ◽  
Cell Growth ◽  
B Cell ◽  
Common Variable Immunodeficiency ◽  
Abnormal Response ◽  
B Cell Growth Factor ◽  
Common Variable ◽  
Human B Cell

The role of toll-like receptors in B-cell development and immunopathogenesis of common variable immunodeficiency

2015 ◽  
Vol 12 (2) ◽  
pp. 195-207 ◽  
Author(s):  
Laleh Sharifi ◽  
Abbas Mirshafiey ◽  
Nima Rezaei ◽  
Gholamreza Azizi ◽  
Kabir Magaji Hamid ◽  
...  
Keyword(s):  
B Cell ◽  
Common Variable Immunodeficiency ◽  
Cell Development ◽  
B Cell Development ◽  
Toll Like Receptors ◽  
Common Variable
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