Laryngeal mucous membrane pemphigoid serves as a prognostic factor for poor response to treatment with rituximab

2021 ◽  
Author(s):  
A. Baniel ◽  
Y. Oestreicher‐Kedem ◽  
A. Peled ◽  
E. Bar‐Ilanv ◽  
S. Geller ◽  
...  
Keyword(s):  
Prognostic Factor ◽  
Mucous Membrane ◽  
Poor Response ◽  
Response To Treatment ◽  
Mucous Membrane Pemphigoid

scholarly journals Oral Pemphigoid Recalcitrant Lesion Treated with PRGF Infiltration. Case Report

2021 ◽  
Vol 9 (11) ◽  
pp. 137
Author(s):  
Eduardo Anitua ◽  
Mohammad H. Alkhraisat ◽  
Asier Eguia ◽  
Laura Piñas
Keyword(s):  
Mucous Membrane ◽  
Low Dose ◽  
Immunosuppressive Treatment ◽  
Poor Response ◽  
Future Research ◽  
Mucous Membrane Pemphigoid ◽  
Oral Lesions ◽  
Almost All ◽  
Oral Involvement

Mucous membrane pemphigoid (MMP) is a heterogeneous group of chronic autoimmune subepithelial blistering diseases. Oral involvement is present in almost all patients, may represent the onset of the disease, and causes different degrees of pain, dysphagia, soreness, and bleeding. Treatment is based on systemic and/or oral corticoids, or other immunosuppressants. Occasionally, oral lesions can show a poor response to standard treatments. We present the case of a 61-year-old female patient with a painful extensive MMP oral ulcerative lesion recalcitrant to previous systemic azathioprine and local triamcinolone treatment, which was successfully treated in a novel way using PRGF infiltrations as adjuvant. After four weekly infiltrations, pain was reduced from 10 to 0 in a VAS and the lesion was completely healed. The patient continued with a low dose maintenance immunosuppressive treatment (prednisone 5 mg/day PO), and after 13 months of follow-up, there was no relapse of the lesion and no side effects. Although future research is necessary to confirm these observations, PRGF could be a useful adjuvant for the management of extensive mucous membrane pemphigoid oral lesions.

A Case of Anti-BP180-type Mucous Membrane Pemphigoid with Esophageal, Genital and Ophthalmic Lesions

2014 ◽  
Vol 76 (4) ◽  
pp. 345-348
Author(s):  
Toshikazu OMODAKA ◽  
Hisashi UHARA ◽  
Ryuhei UCHIYAMA ◽  
Tasuku SANO ◽  
Hitomi KUBO ◽  
...  
Keyword(s):  
Mucous Membrane ◽  
Mucous Membrane Pemphigoid

Criteria positive and criteria negative anaphylaxis, with a focus on undifferentiated somatoform idiopathic anaphylaxis: A review and case series

2020 ◽  
Vol 41 (6) ◽  
pp. 436-441 ◽  
Author(s):  
Daniel A. Rosloff ◽  
Kunal Patel ◽  
Paul J. Feustel ◽  
Jocelyn Celestin
Keyword(s):  
Diagnostic Criteria ◽  
Statistical Significance ◽  
Case Series ◽  
Poor Response ◽  
Response To Treatment ◽  
Fisher Exact Test ◽  
Subjective Symptoms ◽  
Significant Difference ◽  
Physical Findings ◽  
Idiopathic Anaphylaxis

Background: Undifferentiated somatoform (US) idiopathic anaphylaxis (IA) is considered a psychogenic disorder characterized by a lack of observable physical findings and poor response to treatment. Although failure to diagnose true anaphylaxis can have disastrous consequences, identification of US-IA is crucial to limit unnecessary expenses and use of health care resources. Objective: To better define the presentation and understand the potential relationship between US-IA and underlying psychiatric comorbidities. Methods: We retrospectively reviewed 110 visits by 107 patients to our institution for evaluation and management of anaphylaxis over a 1-year period. The patients were classified as having either criteria positive (CP) or criteria negative (CN) anaphylaxis based on whether they met Second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network Symposium criteria for the clinical diagnosis of anaphylaxis. Patient characteristics, including objective and subjective signs and symptoms, and the presence of psychiatric diagnoses were collected and analyzed. Statistical significance was assessed by using the Fisher exact test. A literature review of US-IA and other psychogenic forms of anaphylaxis was performed. Results: Patients with CP anaphylaxis were more likely to present with hypotension, wheezing, urticaria, and vomiting than were patients with CN anaphylaxis. The patients with CN anaphylaxis were more likely to present with subjective symptoms of sensory throat tightness or swelling compared with patients with CP anaphylaxis. No significant difference was detected in the prevalence of psychiatric conditions between the two groups. Conclusion: Patients who met previously established diagnostic criteria for anaphylaxis were more likely to present with objective physical findings than those who did not meet criteria for true anaphylaxis. CN patients who presented for treatment of anaphylaxis were more likely to present with subjective symptoms. Formal diagnostic criteria should be used by clinicians when evaluating patients with suspected anaphylaxis.

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