scholarly journals Expression of hedgehog signaling molecules in microcystic adnexal carcinoma

2021 ◽  
Author(s):  
T. Gambichler ◽  
I. Hartenstein ◽  
M. Dreißigacker ◽  
E. Stockfleth ◽  
J. Schaller ◽  
...  
Keyword(s):  
Hedgehog Signaling ◽  
Signaling Molecules ◽  
Microcystic Adnexal Carcinoma

Hedgehog Signaling Molecules in Bone Marrow Cells at the Initial Stage of Fracture Repair

1999 ◽  
Vol 262 (2) ◽  
pp. 443-451 ◽  
Author(s):  
Hiromu Ito ◽  
Haruhiko Akiyama ◽  
Chohei Shigeno ◽  
Ken-ichi Iyama ◽  
Hideaki Matsuoka ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Hedgehog Signaling ◽  
Bone Marrow Cells ◽  
Signaling Molecules ◽  
Fracture Repair ◽  
Initial Stage ◽  
Marrow Cells

scholarly journals Enhanced expression of hedgehog signaling molecules in squamous cell carcinoma of uterine cervix and its precursor lesions

2006 ◽  
Vol 19 (8) ◽  
pp. 1139-1147 ◽  
Author(s):  
Yan Hua Xuan ◽  
Hun Soon Jung ◽  
Yoon-La Choi ◽  
Young Kee Shin ◽  
Hee Jin Kim ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Uterine Cervix ◽  
Hedgehog Signaling ◽  
Signaling Molecules ◽  
Precursor Lesions ◽  
Enhanced Expression

Expression of hedgehog signaling molecules as a prognostic indicator of oral squamous cell carcinoma

Head & Neck ◽  
2012 ◽  
Vol 34 (11) ◽  
pp. 1556-1561 ◽  
Author(s):  
Yi-Fen Wang ◽  
Chun-Ju Chang ◽  
Chin-Ping Lin ◽  
Shyue-Yih Chang ◽  
Pen-Yuan Chu ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Hedgehog Signaling ◽  
Prognostic Indicator ◽  
Signaling Molecules

Expression of hedgehog signaling molecules in lung cancer

2011 ◽  
Vol 113 (5) ◽  
pp. 564-569 ◽  
Author(s):  
Shuhong Huang ◽  
Ling Yang ◽  
Yunhe An ◽  
Xiaoli Ma ◽  
Chi Zhang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Hedgehog Signaling ◽  
Signaling Molecules

scholarly journals Overexpression of Hedgehog Signaling Molecules and Its Involvement in the Proliferation of Endometrial Carcinoma Cells

2007 ◽  
Vol 13 (5) ◽  
pp. 1389-1398 ◽  
Author(s):  
Yu-Zhen Feng ◽  
Tanri Shiozawa ◽  
Tsutomu Miyamoto ◽  
Hiroyasu Kashima ◽  
Miyuki Kurai ◽  
...  
Keyword(s):  
Endometrial Carcinoma ◽  
Hedgehog Signaling ◽  
Signaling Molecules ◽  
Carcinoma Cells

Expression of Sonic hedgehog signaling molecules in normal, hyperplastic and carcinomatous endometrium

2009 ◽  
Vol 59 (5) ◽  
pp. 279-287 ◽  
Author(s):  
Kyung Hee Kim ◽  
Jin Man Kim ◽  
Yoon-La Choi ◽  
Young Kee Shin ◽  
Ho-chang Lee ◽  
...  
Keyword(s):  
Sonic Hedgehog ◽  
Hedgehog Signaling ◽  
Signaling Molecules ◽  
Sonic Hedgehog Signaling

Expression of hedgehog signaling molecules in Merkel cell carcinoma

Head & Neck ◽  
2009 ◽  
pp. NA-NA ◽  
Author(s):  
Markus Brunner ◽  
Dietmar Thurnher ◽  
Johannes Pammer ◽  
Gregor Heiduschka ◽  
Peter Petzelbauer ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Hedgehog Signaling ◽  
Signaling Molecules ◽  
Merkel Cell

scholarly journals Hedgehog Signaling, a Critical Pathway Governing the Development and Progression of Hepatocellular Carcinoma

Cells ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 123
Author(s):  
Jia Ding ◽  
Hui-Yan Li ◽  
Li Zhang ◽  
Yuan Zhou ◽  
Jian Wu
Keyword(s):  
Hepatocellular Carcinoma ◽  
Drug Resistance ◽  
Hedgehog Signaling ◽  
Target Genes ◽  
Relevant Literature ◽  
Hepatoma Cells ◽  
Signaling Molecules ◽  
Molecular Profile ◽  
Critical Pathway ◽  
Hh Signaling

Hedgehog (Hh) signaling is a classic morphogen in controlling embryonic development and tissue repairing. Aberrant activation of Hh signaling has been well documented in liver cancer, including hepatoblastoma, hepatocellular carcinoma (HCC) and cholangiocarcinoma. The present review aims to update the current understanding on how abnormal Hh signaling molecules modulate initiation, progression, drug resistance and metastasis of HCC. The latest relevant literature was reviewed with our recent findings to provide an overview regarding the molecular interplay and clinical relevance of the Hh signaling in HCC management. Hh signaling molecules are involved in the transformation of pre-carcinogenic lesions to malignant features in chronic liver injury, such as nonalcoholic steatohepatitis. Activation of GLI target genes, such as ABCC1 and TAP1, is responsible for drug resistance in hepatoma cells, with a CD133−/EpCAM− surface molecular profile, and GLI1 and truncated GLI1 account for the metastatic feature of the hepatoma cells, with upregulation of matrix metalloproteinases. A novel bioassay for the Sonic Hh ligand in tissue specimens may assist HCC diagnosis with negative α-fetoprotein and predict early microvascular invasion. In-depth exploration of the Hh signaling deepens our understanding of its molecular modulation in HCC initiation, drug sensitivity and metastasis, and guides precise management of HCC on an individual basis.

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