The controversy of complete lymph node dissection; reply to ‘Completion lymphadenectomy should not necessarily be recommended after a positive SLN biopsy’

2018 ◽  
Vol 44 (1) ◽  
pp. 94-95
Author(s):  
A. Desai ◽  
R. Ugorji ◽  
A. Khachemoune
Keyword(s):  
Lymph Node ◽  
Lymph Node Dissection ◽  
Node Dissection ◽  
Complete Lymph Node Dissection

Survival of SLNB-positive melanoma patients with and without complete lymph node dissection: A multicenter, randomized DECOG trial.

2015 ◽  
Vol 33 (18_suppl) ◽  
pp. LBA9002-LBA9002 ◽  
Author(s):  
Ulrike Leiter ◽  
Rudolf Stadler ◽  
Cornelia Mauch ◽  
Werner Hohenberger ◽  
Norbert Brockmeyer ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Dissection ◽  
Distant Metastases ◽  
Tumor Burden ◽  
Phase Iii ◽  
Node Dissection ◽  
Significant Treatment ◽  
Melanoma Patients ◽  
Complete Lymph Node Dissection

LBA9002 Background: Complete lymph node dissection (CLND) following positive sentinel node biopsy (SLNB) was evaluated in a randomized phase III trial. Methods: 1,258 patients with cutaneous melanoma of the trunk and extremities and with positive SLNB were evaluated. Of these, 483 (39%) agreed to randomization into the clinical trial. 241 patients underwent observation only, 242 received CLND. Both groups had a subsequent 3-years follow-up. Recurrence-free (RFS), distant metastases free (DMFS) and melanoma specific (MSS) survival were analyzed as endpoints. Results: Patient enrolment was performedfrom January 2006 to December 2014. In the intent to treat analysis, both groups did not differ significantly in distribution of age, gender, localization, ulceration, tumor thickness (median 2,4 mm in both groups), number of positive nodes, or tumor burden in the SN. The mean follow-up time was 34 months (SD ± 22.1). No significant treatment-related difference was seen in the 5-years RFS (P = 0.72), DMFS (P= 0 .76) and MSS (P = 0.86) in the overall study population. Conclusions: In this early analysis of trial results, no survival benefit was achieved by CLND in melanoma patients with positive SLNB. A subsequent analysis three years after inclusion of the last patient is planned.

Low incidence of nonsentinel node-positivity after complete lymph node dissection in melanoma patients with positive sentinel nodes

2007 ◽  
Vol 12 (3) ◽  
pp. 242-243
Author(s):  
Arata Tsutsumida ◽  
Hiroshi Furukawa ◽  
Yuhei Yamamoto ◽  
Katsumi Horiuchi ◽  
Tetsunori Yoshida ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Dissection ◽  
Node Dissection ◽  
Sentinel Nodes ◽  
Melanoma Patients ◽  
Low Incidence ◽  
Nonsentinel Node ◽  
Complete Lymph Node Dissection

Is there a therapeutic benefit of complete lymph node dissection in melanoma patients with low tumor burden in the sentinel node?

2014 ◽  
Vol 24 (5) ◽  
pp. 454-461 ◽  
Author(s):  
Imke Satzger ◽  
Andre Meier ◽  
Antonia Zapf ◽  
Margarete Niebuhr ◽  
Alexander Kapp ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Node ◽  
Lymph Node Dissection ◽  
Therapeutic Benefit ◽  
Tumor Burden ◽  
Node Dissection ◽  
Melanoma Patients ◽  
Complete Lymph Node Dissection

Tonsil Metastasis from Cutaneous Melanoma: First Clinical Sign of Recurrence after Complete Lymph Node Dissection

2010 ◽  
Vol 14 (1) ◽  
pp. 43-45 ◽  
Author(s):  
Roberto Cecchi ◽  
Mario Pavesi ◽  
Pierantonio Calamandrei ◽  
Valentina Rapicano ◽  
Cataldo De Gaudio
Keyword(s):  
Lymph Node ◽  
Lymph Node Dissection ◽  
Rare Event ◽  
Palatine Tonsil ◽  
Careful Examination ◽  
Left Shoulder ◽  
Melanoma Metastasis ◽  
Node Dissection ◽  
Case Presentation ◽  
Complete Lymph Node Dissection

Background:The development of melanoma metastasis to the palatine tonsil is a very rare event, generally associated with advanced-stage disease and poor prognosis.Case Presentation:A 29-year-old man presented with a melanoma metastasis to the right palatine tonsil 6 months after the surgical excision of an ulcerated nodular melanoma (tumor thickness 1.8 mm, Clark level IV) on the left shoulder. A metastatic sentinel lymph node had been removed from the left axilla, and a subsequent complete lymph node dissection had disclosed no further metastatic lymph nodes. Although staging tests had revealed multiple visceral metastases, a palliative tonsillectomy was performed. The patient died of metastases 5 months later.Conclusion:The case presentation suggests that careful examination of the head and neck should be part of the routine follow-up visit in all melanoma patients.

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