Lichen planopilaris in a Latin American (Chilean) population: demographics, clinical profile and treatment experience

2017 ◽  
Vol 42 (7) ◽  
pp. 755-759 ◽  
Author(s):  
F. Mardones ◽  
J. Shapiro
Keyword(s):  
Latin American ◽  
Clinical Profile ◽  
Population Demographics ◽  
Treatment Experience ◽  
Lichen Planopilaris ◽  
Chilean Population

scholarly journals Access to healthcare for deaf people: a model from a middle-income country in Latin America

2020 ◽  
Vol 54 ◽  
pp. 13
Author(s):  
Eduardo Fuentes-López ◽  
Adrian Fuente
Keyword(s):  
General Population ◽  
Latin American ◽  
Healthcare Access ◽  
Population Based ◽  
Multivariate Logistic Regression Model ◽  
Deaf People ◽  
Middle Income ◽  
Deaf Women ◽  
Chilean Population ◽  
Prelingually Deaf

OBJECTIVE: To determine if there are existing healthcare access inequities among the deaf Chilean population when compared to the general Chilean population. METHODS: Data were obtained from a population-based national survey in Chile. In total, 745 prelingually deaf individuals were identified. The number of times the person used the healthcare system was dichotomized and analyzed using a multivariate logistic regression model. RESULTS: Prelingually deaf people had lower incomes, fewer years of education, and greater rates of unemployment and poverty when compared with the general population. Moreover, they visited more general practitioners, mental health specialists, and other medical specialists. On average, they attended more appointments for depression but had fewer general checkups and gynecological appointments than the general population. CONCLUSIONS: Deaf people in Chile have a lower socioeconomic status than the rest of the Chilean population. The results from this study are similar to the findings reported for high-income countries, despite differences in the magnitude of the associations between being deaf and healthcare access. Further studies should be conducted to determine the health status of deaf people in Chile and other Latin American countries and what factors are associated with a significantly lower prevalence of gynecological appointments among deaf women when compared with non-deaf women.

scholarly journals Novel Risk Associations between microRNA Polymorphisms and Gastric Cancer in a Chilean Population

2021 ◽  
Vol 23 (1) ◽  
pp. 467
Author(s):  
Natalia Landeros ◽  
Alejandro H. Corvalan ◽  
Maher Musleh ◽  
Luis A. Quiñones ◽  
Nelson M. Varela ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Latin American ◽  
Seed Region ◽  
Mirna Genes ◽  
Healthy Donors ◽  
Geographical Regions ◽  
H Pylori ◽  
Chilean Population ◽  
Novel Associations ◽  
Control Study

Gastric cancer (GC) is the fifth leading cause of cancer deaths in the world, with variations across geographical regions and ethnicities. Emerging evidence indicates that miRNA expression is dysregulated in GC and its polymorphisms may contribute to these variations, which has yet to be explored in Latin American populations. In a case-control study of 310 GC patients and 311 healthy donors from Chile, we assessed the association of 279 polymorphisms in 242 miRNA genes. Two novel polymorphisms were found to be associated with GC: rs4822739:C>G (miR-548j) and rs701213:T>C (miR-4427). Additionally, rs1553867776:T>TCCCCA (miR-4274) and rs12416605:C>T (miR-938) were associated with intestinal-type GC, and rs4822739:C>G (miR-548j) and rs1439619:T>G (miR-3175) with TNM I-II stage. The polymorphisms rs6149511:T> TGAAGGGCTCCA (miR-6891), rs404337:G>A (miR-8084), and rs1439619:T>G (miR-3175) were identified among H.pylori-infected GC patients and rs7500280:T>C (miR-4719) and rs1439619:T>G (miR-3175) were found among H. pylori cagPAI+ infected GC cases. Prediction analysis suggests that seven polymorphisms could alter the secondary structure of the miRNA, and the other one is located in the seed region of miR-938. Targets of miRNAs are enriched in GC pathways, suggesting a possible biological effect. In this study, we identified seven novel associations and replicated one previously described in Caucasian population. These findings contribute to the understanding of miRNA genetic polymorphisms in the GC pathogenesis.

Paediatric cardiomyopathies: echocardiographic diagnosis, clinical profile, and demographic characteristics: the experience of a tertiary referral centre for Latin American paediatric cardiology

2020 ◽  
Vol 30 (4) ◽  
pp. 462-467 ◽  
Author(s):  
Víctor M. Huertas-Quiñones ◽  
Camilo F. Mestra ◽  
Valeria Peña-Trujillo ◽  
Sebastián Gallo-Bernal ◽  
Mariana Villaveces ◽  
...  
Keyword(s):  
Latin American ◽  
Adult Population ◽  
Epidemiologic Study ◽  
Paediatric Population ◽  
Clinical Profile ◽  
World Health ◽  
Referral Centre ◽  
Tertiary Referral ◽  
Tertiary Referral Centre ◽  
Paediatric Cardiology

AbstractBackground:Although multiple studies have been conducted in the adult population, there is a vast knowledge gap regarding the epidemiologic characteristics of cardiomyopathies in the paediatric population. This issue is even more crucial when the precarious situation of medical research in Latin America is considered. Given the potential impact that these disorders could have on Latin American health systems, a comprehensive epidemiologic study regarding the clinical profile and sociodemographic characteristics of these patients will influence the way we approach paediatric cardiomyopathies.Methods:An observational retrospective study was conducted at a tertiary referral centre for Colombian and Latin American paediatric cardiology. We analysed all cases of primary cardiomyopathies in children younger than 18 years of age who presented at our institution between 2010 and 2016. Cases of cardiomyopathies were classified according to World Health Organization guidelines.Results:From a total of 29,533 children who attended our institution during the study period, 89 new cases of primary cardiomyopathies were identified. The median age at diagnosis was 11 years (interquartile range 4–9). Dilated cardiomyopathy accounted for 57.3% (n = 51) of cases; hypertrophic cardiomyopathy, 12.3% (n = 11); restrictive cardiomyopathy, 8.9% (n = 8); non-compacted cardiomyopathy, 7.8% (n = 7); arrhythmogenic ventricular cardiomyopathy, 6.7% (n = 6); and unspecified cardiomyopathy, 6.7% (n = 6). Heart failure was observed in 53.93% of the patients. The overall mortality was 12.36% (n = 11), which included two of eight patients who underwent cardiac transplantation.

scholarly journals Characterization of Chilean patients with sporadic colorectal cancer according to the three main carcinogenic pathways: Microsatellite instability, CpG island methylator phenotype and Chromosomal instability

Tumor Biology ◽  
2020 ◽  
Vol 42 (7) ◽  
pp. 101042832093849 ◽  
Author(s):  
Ana María Wielandt ◽  
Claudia Hurtado ◽  
Mauricio Moreno C ◽  
Cynthia Villarroel ◽  
Magdalena Castro ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Latin American ◽  
Chromosomal Instability ◽  
Cpg Island ◽  
Sporadic Colorectal Cancer ◽  
Cpg Island Methylator Phenotype ◽  
Kras Mutations ◽  
Group 3 ◽  
Methylator Phenotype ◽  
Chilean Population

Molecular classification of colorectal cancer is difficult to implement in clinical settings where hundreds of genes are involved, and resources are limited. This study aims to characterize the molecular subtypes of patients with sporadic colorectal cancer based on the three main carcinogenic pathways microsatellite instability (MSI), CpG island methylator phenotype (CIMP), and chromosomal instability (CIN) in a Chilean population. Although several reports have characterized colorectal cancer, most do not represent Latin-American populations. Our study includes 103 colorectal cancer patients who underwent surgery, without neoadjuvant treatment, in a private hospital between 2008 and 2017. MSI, CIN, and CIMP status were assessed. Frequent mutations in KRAS, BRAF, and PIK3CA genes were analyzed by Sanger sequencing, and statistical analysis was performed by Fisher’s exact and/or chi-square test. Survival curves were estimated with Kaplan–Meier and log-rank test. Based on our observations, we can classify the tumors in four subgroups, Group 1: MSI-high tumors (15%) are located in the right colon, occur at older age, and 60% show a BRAF mutation; Group 2: CIN-high tumors (38%) are in the left colon, and 26% have KRAS mutations. Group 3: [MSI/CIN/CIMP]-low/negative tumors (30%) are left-sided, and 39% have KRAS mutations; Group 4: CIMP-high tumors (15%) were more frequent in men and left side colon, with 27% KRAS and 7% presented BRAF mutations. Three percent of patients could not be classified. We found that CIMP-high was associated with a worse prognosis, both in MSI-high and MSI stable patients (p = 0.0452). Group 3 (Low/negative tumors) tend to have better overall survival compared with MSI-high, CIMP-high, and CIN-high tumors. This study contributes to understanding the heterogeneity of tumors in the Chilean population being one of the few characterizations performed in Latin-America. Given the limited resources of these countries, these results allow to improve molecular characterization in Latin-American colorectal cancer populations and confirm the possibility of using the three main carcinogenic pathways to define therapeutic strategies.

Frontal fibrosing alopecia in males: demographics, clinical profile and treatment experience

2020 ◽  
Vol 34 (2) ◽  
Author(s):  
E. Peterson ◽  
D. Gutierrez ◽  
N.K. Brinster ◽  
K.I. Lo Sicco ◽  
J. Shapiro
Keyword(s):  
Clinical Profile ◽  
Treatment Experience
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