Myeloid differentiation protein‐2 has a protective role in house dust mite‐mediated asthmatic characteristics with the proinflammatory regulation of airway epithelial cells and dendritic cells

2021 ◽  
Author(s):  
Takashi Ishii ◽  
Yusuke Murakami ◽  
Tomoya Narita ◽  
Hiroki Nunokawa ◽  
Kensuke Miyake ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Epithelial Cells ◽  
House Dust ◽  
House Dust Mite ◽  
Protective Role ◽  
Airway Epithelial Cells ◽  
Myeloid Differentiation ◽  
Airway Epithelial ◽  
Dust Mite

House dust mite regulate the lung inflammation of asthmatic mice through TLR4 pathway in airway epithelial cells

2010 ◽  
Vol 28 (7) ◽  
pp. 597-603 ◽  
Author(s):  
Li Hongjia ◽  
Gai Qingling ◽  
Lin Meiying ◽  
Wang Weixuan ◽  
Zhang Lihong ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
House Dust ◽  
House Dust Mite ◽  
Lung Inflammation ◽  
Airway Epithelial Cells ◽  
Airway Epithelial ◽  
Dust Mite

scholarly journals The house dust mite allergen Der p 5 binds lipid ligands and stimulates airway epithelial cells through a TLR2-dependent pathway

2018 ◽  
Vol 49 (3) ◽  
pp. 378-390 ◽  
Author(s):  
Pinya Pulsawat ◽  
Tewarit Soongrung ◽  
Pattraporn Satitsuksanoa ◽  
Maxime Le Mignon ◽  
Souad Khemili ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
House Dust ◽  
House Dust Mite ◽  
Airway Epithelial Cells ◽  
Mite Allergen ◽  
Airway Epithelial ◽  
House Dust Mite Allergen ◽  
Dust Mite ◽  
Dust Mite Allergen ◽  
Dependent Pathway

House dust mite-derived allergens effect on matrix metalloproteases in airway epithelial cells

2021 ◽  
pp. 1-15
Author(s):  
Dilara Karaguzel ◽  
Basak Ezgi Sarac ◽  
Hayriye Akel Bilgic ◽  
Gokce Yagmur Summak ◽  
Mehmet Altay Unal ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
House Dust ◽  
House Dust Mite ◽  
Airway Epithelial Cells ◽  
Matrix Metalloproteases ◽  
Airway Epithelial ◽  
Dust Mite

scholarly journals lncRNA profiling in NCI-H292 cells after stimulation with Dermatophagoides farinae extracts

2018 ◽  
Vol 31 ◽  
pp. 039463201775099
Author(s):  
Lilei Wang ◽  
Ying Zhou ◽  
Yubao Cui
Keyword(s):  
Epithelial Cells ◽  
House Dust ◽  
House Dust Mite ◽  
Bioinformatic Analysis ◽  
Mapk Signaling ◽  
Airway Epithelial Cells ◽  
Messenger Rnas ◽  
Airway Epithelial ◽  
Dermatophagoides Farinae ◽  
Dust Mite

Airway epithelium cells are the first line of defense against airborne allergens. When cultured, epithelial cells can be exposed to various allergens, providing an ideal model to investigate allergic disorders. This study sought to characterize the profile of long noncoding (lnc) RNAs, which can regulate gene expression and exert functions in diverse cellular processes, in airway epithelial cells exposed to house dust mite allergens. NCI-H292 cells were exposed to house dust mite extract for 24 h. RNA expression was profiled in exposed and unexposed cells. There were 270 lncRNAs that were differentially expressed (fold change ≥ 2, P < 0.05) in NCI-H292 cells after stimulation with Dermatophagoides farinae (house dust mite) extracts. Furthermore, 119 lncRNAs and 22 messenger RNAs were co-expressed. Gene Ontology analysis showed that these under-regulated and up-regulated lncRNAs were associated with biological process, cellular component, and molecular function. After bioinformatic analysis of significantly regulated signaling pathways, we found these lncRNAs may target 16 gene pathways, including glycolysis, axon guidance, ErbB signaling, and mitogen-activated protein kinases (MAPK) signaling. The identification of differentially regulated lncRNAs in NCI-H292 cells after stimulation with Dermatophagoides farinae extracts, as well as their target gene pathways, can provide insight to the etiology and pathogenesis of allergy.

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