scholarly journals Characterization of anaphylaxis reveals different metabolic changes depending on severity and triggers

2021 ◽  
Author(s):  
Carolina Perales‐Chorda ◽  
David Obeso ◽  
Laura Twomey ◽  
Ayelén Rojas‐Benedicto ◽  
Leonor Puchades‐Carrasco ◽  
...  
Keyword(s):  
Metabolic Changes

scholarly journals Pharmacometabolomics by NMR in Oncology: A Systematic Review

2021 ◽  
Vol 14 (10) ◽  
pp. 1015
Author(s):  
Nuria Gómez-Cebrián ◽  
Pedro Vázquez Ferreiro ◽  
Francisco Javier Carrera Hueso ◽  
José Luis Poveda Andrés ◽  
Leonor Puchades-Carrasco ◽  
...  
Keyword(s):  
Drug Efficacy ◽  
Metabolic Changes ◽  
Therapeutic Interventions ◽  
Significant Advance ◽  
Metabolic Profiles ◽  
Efficacy And Safety ◽  
Drug Treatments ◽  
Experimental Approaches ◽  
Analytical Platforms

Pharmacometabolomics (PMx) studies aim to predict individual differences in treatment response and in the development of adverse effects associated with specific drug treatments. Overall, these studies inform us about how individuals will respond to a drug treatment based on their metabolic profiles obtained before, during, or after the therapeutic intervention. In the era of precision medicine, metabolic profiles hold great potential to guide patient selection and stratification in clinical trials, with a focus on improving drug efficacy and safety. Metabolomics is closely related to the phenotype as alterations in metabolism reflect changes in the preceding cascade of genomics, transcriptomics, and proteomics changes, thus providing a significant advance over other omics approaches. Nuclear Magnetic Resonance (NMR) is one of the most widely used analytical platforms in metabolomics studies. In fact, since the introduction of PMx studies in 2006, the number of NMR-based PMx studies has been continuously growing and has provided novel insights into the specific metabolic changes associated with different mechanisms of action and/or toxic effects. This review presents an up-to-date summary of NMR-based PMx studies performed over the last 10 years. Our main objective is to discuss the experimental approaches used for the characterization of the metabolic changes associated with specific therapeutic interventions, the most relevant results obtained so far, and some of the remaining challenges in this area.

Characterization of Temporary Metabolic Changes Following Cantonese Herbal Tea Intervention

2012 ◽  
Vol 26 (7) ◽  
pp. 1097-1102 ◽  
Author(s):  
Rong You ◽  
Zhenbo Xu ◽  
Songqing Hu ◽  
Lin Li
Keyword(s):  
Metabolic Changes ◽  
Herbal Tea

scholarly journals Characterization of the metabolic changes underlying growth factor angiogenic activation: identification of new potential therapeutic targets

2009 ◽  
Vol 30 (6) ◽  
pp. 946-952 ◽  
Author(s):  
P. Vizan ◽  
S. Sanchez-Tena ◽  
G. Alcarraz-Vizan ◽  
M. Soler ◽  
R. Messeguer ◽  
...  
Keyword(s):  
Growth Factor ◽  
Therapeutic Targets ◽  
Metabolic Changes ◽  
Angiogenic Activation

scholarly journals Characterization of cell metabolic changes in osteoarthritic labrum cells

2013 ◽  
Vol 21 ◽  
pp. S224
Author(s):  
N. Juchtmans ◽  
A. Dhollander ◽  
S. Lambrecht ◽  
D. Elewaut
Keyword(s):  
Metabolic Changes
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