Small nucleolar RNA networks are upregulated during human anaphylaxis

2021 ◽  
Author(s):  
F McGrath ◽  
A Francis ◽  
D Fatovich ◽  
S Macdonald ◽  
G Arendts ◽  
...  
Keyword(s):  
Small Nucleolar Rna ◽  
Nucleolar Rna

Small nucleolar RNA host genes promoting epithelial–mesenchymal transition lead cancer progression and metastasis

IUBMB Life ◽  
2021 ◽  
Author(s):  
Alessio Biagioni ◽  
Shima Tavakol ◽  
Nooshin Ahmadirad ◽  
Masoumeh Zahmatkeshan ◽  
Lucia Magnelli ◽  
...  
Keyword(s):  
Cancer Progression ◽  
Epithelial Mesenchymal Transition ◽  
Small Nucleolar Rna ◽  
Mesenchymal Transition ◽  
Nucleolar Rna ◽  
Host Genes

Distribution of U3 small nucleolar RNA and fibrillarin during early embryogenesis in Caenorhabditis elegans

Biochimie ◽  
2008 ◽  
Vol 90 (6) ◽  
pp. 898-907 ◽  
Author(s):  
Yumi Sasano ◽  
Yusuke Hokii ◽  
Kunio Inoue ◽  
Hiroshi Sakamoto ◽  
Chisato Ushida ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Early Embryogenesis ◽  
Small Nucleolar Rna ◽  
Nucleolar Rna

scholarly journals Upregulation of Long Non-Coding RNA Small Nucleolar RNA Host Gene 12 Contributes to Cell Growth and Invasion in Cervical Cancer by Acting as a Sponge for MiR-424-5p

2018 ◽  
Vol 45 (5) ◽  
pp. 2086-2094 ◽  
Author(s):  
Jing Dong ◽  
Qing Wang ◽  
Li Li ◽  
Zhang Xiao-jin
Keyword(s):  
Cervical Cancer ◽  
Tumor Growth ◽  
Cancer Cells ◽  
Host Gene ◽  
Migration And Invasion ◽  
Small Nucleolar Rna ◽  
Cervical Cancer Cells ◽  
Cancer Tissues ◽  
Nucleolar Rna

Background/Aims: Cervical cancer, which is one of the most aggressive cancers affecting females, has high rates of recurrence and mortality. Small nucleolar RNA host gene 12 (SNHG12) is known to promote the progression of several cancers; however, its exact effects and molecular mechanisms in cervical cancer remain unknown. Methods: Real-time quantitative PCR was used to determine the expression level of SNHG12 in cervical cancer tissues and cell lines. Loss-of-function assays were performed to examine the effect of SNHG12 on the proliferation, apoptosis, migration and invasion of cervical cancer cells in vitro and tumor growth in vivo. Luciferase experiments were employed to explore the interactions between SNHG12 and miR-424-5p. Results: SNHG12 was found to be abnormally elevated in human cervical cancer tissues compared with paired adjacent normal tissues. Moreover, high SNHG12 expression in tumor tissues was significantly correlated with vascular involvement, lymph node metastasis, advanced FIGO stage and poor prognosis. Furthermore, the knockdown of SNHG12 was found to inhibit proliferation, migration and invasion of cervical cancer cells in vitro, and silencing SNHG12 was shown to suppress tumor growth in a nude mouse model. Mechanistic studies showed that SNHG12 functioned as an endogenous sponge for miR-424-5p, thereby downregulating the expression of miR-424-5p in cervical cancer. Furthermore, the inhibition of miR-424-5p in SNHG12-depleted cells partially reversed the effects on cervical cancer cell apoptosis, adhesion and invasion. Conclusion: In summary, our findings suggest that the tumor-promoting role of SNHG12 is to function as a molecular sponge, which negatively regulates miR-424-5p. These findings may provide a potent therapeutic target for cervical cancer.

scholarly journals Small nucleolar RNA host gene 1 promotes development and progression of colorectal cancer through negative regulation of miR‐137

2019 ◽  
Vol 58 (11) ◽  
pp. 2104-2117 ◽  
Author(s):  
Yang Fu ◽  
Yuhan Yin ◽  
Sanfei Peng ◽  
Ge Yang ◽  
Yang Yu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Negative Regulation ◽  
Host Gene ◽  
Small Nucleolar Rna ◽  
Nucleolar Rna
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