scholarly journals Aeroallergen sensitisation for detecting asthma in primary care: a diagnostic test accuracy study

Author(s):  
Janwillem W.H. Kocks ◽  
Heinze J.H. Andringa ◽  
Ellen van Heijst ◽  
Renaud Louis ◽  
Inigo Ojanguren Arranz ◽  
...  
2018 ◽  
Vol 45 (5-6) ◽  
pp. 300-307 ◽  
Author(s):  
John C. Williamson ◽  
Andrew J. Larner

Background/Aims: The Mini-Addenbrooke’s Cognitive Examination (MACE) is a relatively new short cognitive screening instrument for the detection of patients with dementia and mild cognitive impairment (MCI). Few studies of the MACE have been reported hitherto. The aim of this study was to undertake a pragmatic diagnostic test accuracy study of MACE in a large cohort of patients seen in a dedicated cognitive disorders clinic. Methods: MACE was administered to consecutive patients referred to a neurology-led Cognitive Function Clinic over the course of 3 years to assess its performance for the diagnosis of dementia and MCI using various test metrics. Results: In a cohort of 599 patients, the prevalence of dementia and MCI by criterion diagnosis was 0.17 and 0.29, respectively. MACE had a high sensitivity (> 0.9) and negative predictive values (> 0.8) with large effect sizes (Cohen’s d > 1) for the diagnosis of both dementia and MCI but a low specificity (< 0.5) and positive predictive values (≤0.5). Conclusion: MACE is an acceptable test for the assessment of cognitive complaints in a secondary care setting with good metrics for identifying cases of both dementia and MCI.


PLoS ONE ◽  
2020 ◽  
Vol 15 (1) ◽  
pp. e0227471 ◽  
Author(s):  
Zoë Tieges ◽  
David J. Stott ◽  
Robert Shaw ◽  
Elaine Tang ◽  
Lisa-Marie Rutter ◽  
...  

2019 ◽  
Author(s):  
Karoline Lukaschek ◽  
Milena Frank ◽  
Kathrin Halfter ◽  
Antonius Schneider ◽  
Jochen Gensichen

Abstract Background: As primary contacts, general practitioners can play a pivotal role in identifying suicidal behaviour in their patients. A brief instrument could help in identifying vulnerable patients. We summarized the available studies reporting diagnostic accuracy of short screening instruments for suicidal behaviour in primary care or the general population in a narrative synthesis. Methods: The databases MEDLINE, EMBASE, PsychINFO, PSYNDEX, and Cochrane Library were searched in January 2019 without any time constraints. Risk of bias and applicability concerns were assessed using the QUADAS-2 tool. The certainty of evidence was rated via GRADEpro. The authors followed the PRISMA extensions for Diagnostic Test Accuracy Studies. Results: We identified a total of 9 969 studies with our search strategy. After the selection process, six relevant studies fulfilled all criteria and were included. They used the following index tests: Kessler Psychological Distress Scale, Suicidal Ideation Screening Questionnaire, Suicidal Ideation Attributes Scale, Gate question suicide attempt, Gate question suicidal ideation, Feeling suicidal, Wishing you were dead, Thoughts of death and Patient-Health-Questionaire-9 - item 9. The diagnostic accuracy measurements sensitivity and specificity had a wide range (sensitivity: 26% - 100%, specificity: 64% - 99%). Risk of bias was rated moderate and concerns regarding applicability acceptable. A required sensitivity of at least 80% and specificity of 50% with a moderate to high GRADE rating was achieved by six of nine index tests. Conclusions: The identified studies were heterogeneous regarding sample size, index test and reference standard. Even though screening of suicidal behaviour in primary care is already recommended by several guidelines, there are only few screeners in primary care that have been examined regarding their diagnostic accuracy. Although they can assist GPs in their judgement of suicidal behaviour of patients at risk, the final assessment is always based on the clinical judgement of the attending physician. Further diagnostic test accuracy studies of promising short questionnaires are needed. Registration: The study protocol was registered at PROSPERO (ID: CRD42019122173).


2018 ◽  
Vol 48 (1) ◽  
pp. 114-121 ◽  
Author(s):  
Jennifer K Burton ◽  
Charis A Marwick ◽  
James Galloway ◽  
Christopher Hall ◽  
Thomas Nind ◽  
...  

2015 ◽  
Vol 6 ◽  
pp. S36
Author(s):  
K. Hendry ◽  
T. Quinn ◽  
H. Miller ◽  
J. Burns ◽  
A.L. Cunnington ◽  
...  

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