Secondhand smoke and NFE2L2 genotype interaction increases pediatric asthma risk and severity

2020 ◽  
Author(s):  
Elisabet Johansson ◽  
Lisa J. Martin ◽  
Hua He ◽  
Xiaoting Chen ◽  
Matthew T. Weirauch ◽  
...  
Keyword(s):  
Secondhand Smoke ◽  
Pediatric Asthma ◽  
Asthma Risk ◽  
Genotype Interaction

scholarly journals The pediatric asthma risk score (PARS): making the move to the most accurate pediatric asthma risk screening tool

2019 ◽  
Vol 15 (11) ◽  
pp. 1115-1118
Author(s):  
Michael G Sherenian ◽  
Jocelyn M. Biagini Myers ◽  
Lisa J. Martin ◽  
Gurjit K. Khurana Hershey
Keyword(s):  
Risk Score ◽  
Screening Tool ◽  
Pediatric Asthma ◽  
Risk Screening ◽  
Asthma Risk

scholarly journals Use of the Pediatric Asthma Risk Score to predict allergic and nonallergic asthma

2020 ◽  
Vol 124 (6) ◽  
pp. 629-631.e2
Author(s):  
Eric Schauberger ◽  
Jocelyn M. Biagini Myers ◽  
Hua He ◽  
Lisa J. Martin ◽  
S. Hasan Arshad ◽  
...  
Keyword(s):  
Risk Score ◽  
Pediatric Asthma ◽  
Asthma Risk

scholarly journals Children with high risk to develop asthma by the Pediatric Asthma Risk Score have more acute symptoms at presentation than those who are low risk

2020 ◽  
Vol 145 (2) ◽  
pp. AB119
Author(s):  
Kelsi Pomeroy ◽  
Darrell Dinwiddie ◽  
Claire Putt ◽  
Ashley Stoner ◽  
Sarah Pham ◽  
...  
Keyword(s):  
High Risk ◽  
Risk Score ◽  
Pediatric Asthma ◽  
Low Risk ◽  
Asthma Risk

scholarly journals Prevalence of Pediatric Asthma Risk in Santo Domingo, Dominican Republic

2017 ◽  
Vol 83 (2) ◽  
pp. 293 ◽  
Author(s):  
Wendy W. Sun ◽  
Lipi Gupta ◽  
Andrew E. Andreae ◽  
Kristin Romutis ◽  
Allison M. Borda ◽  
...  
Keyword(s):  
Dominican Republic ◽  
Pediatric Asthma ◽  
Santo Domingo ◽  
Asthma Risk

scholarly journals Angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to pediatric asthma: A meta-analysis

2020 ◽  
Vol 21 (2) ◽  
pp. 147032032092347
Author(s):  
Zhengyang Shao ◽  
Haili Jin ◽  
Hong Sun ◽  
Chenxia Dong ◽  
Binbin Xu ◽  
...  
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Web Of Science ◽  
Meta Analysis ◽  
Relevant Literature ◽  
Pediatric Asthma ◽  
Recessive Model ◽  
Converting Enzyme ◽  
Inclusion Criteria ◽  
Deletion Polymorphism ◽  
Asthma Risk

Objective: The correlation of the angiotensin-converting enzyme ( ACE) insertion/deletion (I/D) polymorphism with pediatric asthma risk was assessed in this meta-analysis. Methods: PubMed, Web of Science, Embase and CNKI databases were systematically searched for relevant literature, followed by application of odds ratios (OR) along with 95% confidence interval (CI) for determining the strength of relationship. Results: Seven articles with 802 cases and 632 controls fulfilled the inclusion criteria. As a result, the ACE I/D polymorphism was related to elevated pediatric asthma risk (D vs I: OR = 1.87, 95% CI = 1.59–2.20; dominant model: OR =1.53, 95% CI = 1.28–1.81; recessive model: OR =1.54, 95% CI = 1.28–1.85; DD vs II: OR =2.95, 95% CI = 2.19–3.98; DI vs II: OR = 0.96, 95% CI = 0.78–1.19). Subgroup analysis stratified by race revealed significant interrelation in Asians. Conclusion: This meta-analysis demonstrated that the ACE I/D polymorphism might be related to the risk of pediatric asthma.

scholarly journals Perinatal granulopoiesis and risk of pediatric asthma

eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Benjamin A Turturice ◽  
Juliana Theorell ◽  
Mary Dawn Koenig ◽  
Lisa Tussing-Humphreys ◽  
Diane R Gold ◽  
...  
Keyword(s):  
Risk Factors ◽  
Risk Stratification ◽  
Cord Blood ◽  
Mononuclear Cells ◽  
Pediatric Asthma ◽  
Gene Signature ◽  
Asthma Risk ◽  
Specific Granule ◽  
Umbilical Cord Blood Serum ◽  
Epidemiologic Risk

There are perinatal characteristics, such as gestational age, reproducibly associated with the risk for pediatric asthma. Identification of biologic processes influenced by these characteristics could facilitate risk stratification or new therapeutic targets. We hypothesized that transcriptional changes associated with multiple epidemiologic risk factors would be mediators of pediatric asthma risk. Using publicly available transcriptomic data from cord blood mononuclear cells, transcription of genes involved in myeloid differentiation was observed to be inversely associated with a pediatric asthma risk stratification based on multiple perinatal risk factors. This gene signature was validated in an independent prospective cohort and was specifically associated with genes localizing to neutrophil-specific granules. Further validation demonstrated that umbilical cord blood serum concentration of PGLYRP-1, a specific granule protein, was inversely associated with mid-childhood current asthma and early-teen FEV1/FVCx100. Thus, neutrophil-specific granule abundance at birth predicts risk for pediatric asthma and pulmonary function in adolescence.

scholarly journals Association of ADAM33 T1 Polymorphism With Subgroups of Pediatric Asthma Patients in Iran

2020 ◽  
Author(s):  
Mir Reza Ghaemi ◽  
Sara Hemmati ◽  
Arezou Rezaei ◽  
Maryam Sadr ◽  
Bahareh Mohebbi ◽  
...  
Keyword(s):  
Eosinophil Count ◽  
Pulmonary Function Tests ◽  
Disease Onset ◽  
Pediatric Asthma ◽  
Atopic Asthma ◽  
Blood Eosinophil ◽  
Nucleotide Polymorphisms ◽  
Total Blood ◽  
Asthma Risk ◽  
Asthma Patients

There is strong evidence on the interaction of several genetic variations and environmental conditions in the etiology of asthma. Association of a disintegrin and metalloproteinase 33 (ADAM33) with asthma risk is not clear and shows diversity between nations and ethnicities. Several single nucleotide polymorphisms (SNP) of the ADAM33 gene are introduced and studied according to the disease onset and characteristics. The aim of our study is to determine the association of ADAM33 rs2280091 polymorphism and pediatric asthma in the Iranian population. A total of 63 asthma patients (aged 6-18) and 86 healthy controls were enrolled in our study. Asthma type, classification, and severity were defined. SNPs of the ADAM33 gene at rs2280091 (T1) were analyzed. Pulmonary function tests, total blood eosinophil count, and IgE count were also assessed. T1 genotype and allele frequencies were not associated with asthma risk in Iranian pediatric asthma. Atopic asthma subgroup and patients with normal eosinophil count showed association with ADAM33 rs2280091. Moreover, asthma patients with AG genotype showed lower pulmonary functions.

scholarly journals The Pediatric Asthma Risk Score (PARS) Predicts Atopic and Non-atopic Asthma Better than the Asthma Predictive Index

2019 ◽  
Vol 143 (2) ◽  
pp. AB12
Author(s):  
Eric M. Schauberger ◽  
Jocelyn Biagini Myers ◽  
Hua He ◽  
Lisa J. Martin ◽  
John Kroner ◽  
...  
Keyword(s):  
Risk Score ◽  
Pediatric Asthma ◽  
Atopic Asthma ◽  
Predictive Index ◽  
Asthma Risk ◽  
Better Than

scholarly journals NAT1 genetic variation increases asthma risk in children with secondhand smoke exposure

2019 ◽  
pp. 1-9 ◽  
Author(s):  
Cassandra C. Brooks ◽  
Lisa J. Martin ◽  
Valentina Pilipenko ◽  
Hua He ◽  
Grace K. LeMasters ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Secondhand Smoke ◽  
Smoke Exposure ◽  
Secondhand Smoke Exposure ◽  
Asthma Risk
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