scholarly journals A hybrid of two major Blomia tropicalis allergens as an allergy vaccine candidate

2020 ◽  
Vol 50 (7) ◽  
pp. 835-847
Author(s):  
Eduardo Santos Silva ◽  
Lorenz Aglas ◽  
Carina Silva Pinheiro ◽  
Emília M. M. Andrade Belitardo ◽  
Elisânia Fontes Silveira ◽  
...  
Keyword(s):  
Vaccine Candidate ◽  
Blomia Tropicalis ◽  
Allergy Vaccine

Blomia tropicalis and Cockroaches as Important Allergens

1999 ◽  
Vol 11 (5) ◽  
pp. 0167-0170 ◽  
Author(s):  
L. Arruda ◽  
Virginia Ferriani ◽  
Constance Oliver ◽  
Martin Chapman ◽  
M. Rizzo ◽  
...  
Keyword(s):  
Blomia Tropicalis

Dengue and Zika Virus Infections Are Enhanced by Live Attenuated Dengue Vaccine but Not by Recombinant DSV4 Vaccine Candidate in Mouse Models

2020 ◽  
Author(s):  
Rahul Shukla ◽  
Julia A. Brown ◽  
Hemalatha Beesetti ◽  
Richa Ahuja ◽  
Viswanathan Ramasamy ◽  
...  
Keyword(s):  
Mouse Models ◽  
Zika Virus ◽  
Vaccine Candidate ◽  
Virus Infections ◽  
Dengue Vaccine

Attenuation of a human rotavirus vaccine candidate did not correlate with mutations in the NSP4 protein gene.

1997 ◽  
Vol 71 (8) ◽  
pp. 6267-6270 ◽  
Author(s):  
R L Ward ◽  
B B Mason ◽  
D I Bernstein ◽  
D S Sander ◽  
V E Smith ◽  
...  
Keyword(s):  
Protein Gene ◽  
Vaccine Candidate ◽  
Rotavirus Vaccine ◽  
Human Rotavirus ◽  
Nsp4 Protein

scholarly journals In vitro and in vivo inhibition of malaria parasite infection by monoclonal antibodies against Plasmodium falciparum circumsporozoite protein (CSP)

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Merricka C. Livingstone ◽  
Alexis A. Bitzer ◽  
Alish Giri ◽  
Kun Luo ◽  
Rajeshwer S. Sankhala ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Monoclonal Antibodies ◽  
Disease Burden ◽  
Vaccine Candidate ◽  
Specific Binding ◽  
Circumsporozoite Protein ◽  
Target Epitope ◽  
Selection Of

AbstractPlasmodium falciparum malaria contributes to a significant global disease burden. Circumsporozoite protein (CSP), the most abundant sporozoite stage antigen, is a prime vaccine candidate. Inhibitory monoclonal antibodies (mAbs) against CSP map to either a short junctional sequence or the central (NPNA)n repeat region. We compared in vitro and in vivo activities of six CSP-specific mAbs derived from human recipients of a recombinant CSP vaccine RTS,S/AS01 (mAbs 317 and 311); an irradiated whole sporozoite vaccine PfSPZ (mAbs CIS43 and MGG4); or individuals exposed to malaria (mAbs 580 and 663). RTS,S mAb 317 that specifically binds the (NPNA)n epitope, had the highest affinity and it elicited the best sterile protection in mice. The most potent inhibitor of sporozoite invasion in vitro was mAb CIS43 which shows dual-specific binding to the junctional sequence and (NPNA)n. In vivo mouse protection was associated with the mAb reactivity to the NANPx6 peptide, the in vitro inhibition of sporozoite invasion activity, and kinetic parameters measured using intact mAbs or their Fab fragments. Buried surface area between mAb and its target epitope was also associated with in vivo protection. Association and disconnects between in vitro and in vivo readouts has important implications for the design and down-selection of the next generation of CSP based interventions.

Sign in / Sign up

Export Citation Format

Share Document