scholarly journals Gender, prick test size and rAra h 2 sIgE level may predict the eliciting dose in patients with peanut allergy: Evidence from the Mirabel survey

2019 ◽  
Vol 49 (5) ◽  
pp. 677-689 ◽  
Author(s):  
Chabi Fabrice Elegbede ◽  
Alexandra Papadopoulos ◽  
Jocelyne Just ◽  
Denise Anne Moneret‐Vautrin ◽  
Antoine Deschildre ◽  
...  
Keyword(s):  
Peanut Allergy ◽  
Test Size ◽  
Prick Test ◽  
Sige Level

scholarly journals Estimating the Risk of Severe Peanut Allergy Using Clinical Background and IgE Sensitization Profiles

2021 ◽  
Vol 2 ◽  
Author(s):  
Mareen R. Datema ◽  
Sarah A. Lyons ◽  
Montserrat Fernández-Rivas ◽  
Barbara Ballmer-Weber ◽  
André C. Knulst ◽  
...  
Keyword(s):  
Peanut Allergy ◽  
Predictive Accuracy ◽  
Age At Onset ◽  
Birch Pollen ◽  
Pollen Allergy ◽  
Component Level ◽  
Prick Test ◽  
Skin Contact ◽  
Peanut Extract ◽  
Clinical Background

Background: It is not well-understood why symptom severity varies between patients with peanut allergy (PA).Objective: To gain insight into the clinical profile of subjects with mild-to-moderate and severe PA, and investigate individual and collective predictive accuracy of clinical background and IgE to peanut extract and components for PA severity.Methods: Data on demographics, patient history and sensitization at extract and component level of 393 patients with probable PA (symptoms ≤ 2 h + IgE sensitization) from 12 EuroPrevall centers were analyzed. Univariable and penalized multivariable regression analyses were used to evaluate risk factors and biomarkers for severity.Results: Female sex, age at onset of PA, symptoms elicited by skin contact with peanut, family atopy, atopic dermatitis, house dust mite and latex allergy were independently associated with severe PA; birch pollen allergy with mild-to-moderate PA. The cross-validated AUC of all clinical background determinants combined (0.74) was significantly larger than the AUC of tests for sensitization to extract (0.63) or peanut components (0.54–0.64). Although larger skin prick test wheal size, and higher IgE to peanut extract, Ara h 1 and Ara h 2/6, were associated with severe PA, and higher IgE to Ara h 8 with mild-to-moderate PA, addition of these measurements of sensitization to the clinical background model did not significantly improve the AUC.Conclusions: Models combining clinical characteristics and IgE sensitization patterns can help establish the risk of severe reactions for peanut allergic patients, but clinical background determinants are most valuable for predicting severity of probable PA in an individual patient.

Does skin prick test reactivity to purified allergens correlate with clinical severity of peanut allergy?

2007 ◽  
Vol 37 (1) ◽  
pp. 108-115 ◽  
Author(s):  
K. A. B. M. Peeters ◽  
S. J. Koppelman ◽  
E. van Hoffen ◽  
C. W. H. van der Tas ◽  
C. F. den Hartog Jager ◽  
...  
Keyword(s):  
Skin Prick Test ◽  
Peanut Allergy ◽  
Clinical Severity ◽  
Prick Test

scholarly journals A study to assess current approaches of allergists in European countries diagnosing and managing children and adolescents with peanut allergy

PLoS ONE ◽  
2020 ◽  
Vol 15 (12) ◽  
pp. e0241648
Author(s):  
Vibha Sharma ◽  
Jennifer Jobrack ◽  
Wendy Cerenzia ◽  
Stephen Tilles ◽  
Robert Ryan ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Peanut Allergy ◽  
Negative Impact ◽  
Food Challenge ◽  
Office Visit ◽  
Initial Diagnosis ◽  
Food Allergies ◽  
Prick Test ◽  
The Uk

Rationale Food allergy is documented to result in considerable morbidity, negative impact on quality of life, and substantial medical care costs. Although anecdotal data suggest widely varying practices in the diagnosis and management of food allergies, the diversity and relative frequency of these practices have not been documented. Methods A questionnaire was developed evaluating allergists’ management approaches of individuals with peanut allergy (PA) in Germany (DE), France (FR), and the United Kingdom (UK). Results Here, we report the survey results from a total of 109 allergists from DE, FR and the UK. They reported to confirm PA at initial diagnosis using skin prick test (≥60%), while allergists from DE and FR reported using allergen-specific IgE testing more (>86%) compared to the UK (<50%). At initial diagnosis, oral food challenge was used less in DE (13%) and FR (14%) and very rarely in the UK (3%) to confirm diagnosis. Recognition of acute reactions, use of adrenaline auto-injectors and allergen avoidance were reported to be discussed with the patient/caregiver at the initial office visit by most allergists (>75%). Half of the responders reported assessing the patient’s quality of life. 63% allergists reported retesting for PA resolution at a later date, with 45% allergists indicated to recommend ingestion of a normal serving of peanut regularly upon resolution. Lack of effective PA treatment was reported to be a ‘very significant’ barrier for optimal PA treatment, with allergists being less than ‘moderately familiar’ with data from clinical trials testing new treatments options for PA. Lastly, allergists stated that the severity of patient’s PA ranked as the most important factor in their decision to recommend oral immunotherapy for PA treatment. Conclusions This survey provides essential insights into the practice of allergists and highlights some areas that would inform strategies for education and improving PA healthcare.

scholarly journals Low-dose peanut challenges can facilitate infant peanut introduction regardless of skin prick test size

2020 ◽  
Vol 125 (1) ◽  
pp. 97-99
Author(s):  
Adora Lin ◽  
Burcin Uygungil ◽  
Karen Robbins ◽  
Olivia Ackerman ◽  
Hemant Sharma
Keyword(s):  
Skin Prick Test ◽  
Low Dose ◽  
Test Size ◽  
Prick Test

Natural Course and Prognostic Factors of Immediate-Type Peanut Allergy in Children

2021 ◽  
pp. 1-5
Author(s):  
Minyoung Jung ◽  
Hye-In Jeong ◽  
Yechan Kyung ◽  
Su Kyung Kim ◽  
Ju Suk Lee ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Peanut Allergy ◽  
Challenge Test ◽  
Food Challenge ◽  
Specific Ige ◽  
Natural Course ◽  
Cox Proportional Hazard ◽  
Sige Level ◽  
Tertiary Hospitals ◽  
History Of

<b><i>Background:</i></b> Predicting food allergy resolution is essential to minimize the number of restricted foods in children. However, there have been no studies on the natural history of peanut allergy (PA) in Korea. <b><i>Objective:</i></b> This study aimed to evaluate the natural course and prognostic factors of immediate-type PA in children till the age of 10 years. <b><i>Methods:</i></b> We retrospectively collected data of 122 children who developed PA before 60 months of age from 3 tertiary hospitals in Korea. Diagnosis and resolution of PA was defined as an oral food challenge test or a convincing history of symptoms within 2 h after peanut ingestion. The prognostic factors for resolution of PA were identified using the Cox proportional hazard model. <b><i>Results:</i></b> The median (interquartile range) age at diagnosis was 2.0 (1.3–3.0) years. Among the 122 children, PA resolved in 18 (14.8%) children. The level of peanut-specific IgE (sIgE) at diagnosis in the persistence group was significantly higher than that in the resolution group (<i>p</i> = 0.026). The probabilities of resolution of PA were 10.3% and 32.8% at the ages of 6 and 10 years, respectively. A peanut-sIgE level ≥1 kU/L at diagnosis was significantly associated with persistent PA (hazard ratio, 5.99; 95% confidence interval, 1.89–18.87). <b><i>Conclusions:</i></b> Only 10.3% of our patients had a probability of developing spontaneous resolution of PA by 6 years of age. Peanut-sIgE levels ≥1 kU/L at diagnosis were associated with the persistence of PA.

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