Effects of human rhinovirus on epithelial barrier integrity and function in children with asthma

2018 ◽  
Vol 48 (5) ◽  
pp. 513-524 ◽  
Author(s):  
K. Looi ◽  
A. G. Buckley ◽  
P. J. Rigby ◽  
L. W. Garratt ◽  
T. Iosifidis ◽  
...  
Keyword(s):  
Human Rhinovirus ◽  
Epithelial Barrier ◽  
Barrier Integrity ◽  
Children With Asthma ◽  
And Function

scholarly journals Keep calm: the intestinal barrier at the interface of peace and war

2019 ◽  
Vol 10 (11) ◽  
Author(s):  
Lester Thoo ◽  
Mario Noti ◽  
Philippe Krebs
Keyword(s):  
Inflammatory Diseases ◽  
Pathological Condition ◽  
Treatment Strategies ◽  
Intestinal Barrier ◽  
Cell Types ◽  
Epithelial Barrier ◽  
Barrier Integrity ◽  
Epithelial Barriers ◽  
Underlying Mechanisms ◽  
And Function

Abstract Epithelial barriers have to constantly cope with both harmless and harmful stimuli. The epithelial barrier therefore serves as a dynamic and not static wall to safeguard its proper physiological function while ensuring protection. This is achieved through multiple defence mechanisms involving various cell types - epithelial and non-epithelial - that work in an integrated manner to build protective barriers at mucosal sites. Damage may nevertheless occur, due to pathogens, physical insults or dysregulated immune responses, which trigger a physiologic acute or a pathologic chronic inflammatory cascade. Inflammation is often viewed as a pathological condition, particularly due to the increasing prevalence of chronic inflammatory (intestinal) diseases. However, inflammation is also necessary for wound healing. The aetiology of chronic inflammatory diseases is incompletely understood and identification of the underlying mechanisms would reveal additional therapeutic approaches. Resolution is an active host response to end ongoing inflammation but its relevance is under-appreciated. Currently, most therapies aim at dampening inflammation at damaged mucosal sites, yet these approaches do not efficiently shut down the inflammation process nor repair the epithelial barrier. Therefore, future treatment strategies should also promote the resolution phase. Yet, the task of repairing the barrier can be an arduous endeavour considering its multiple integrated layers of defence - which is advantageous for damage prevention but becomes challenging to repair at multiple levels. In this review, using the intestines as a model epithelial organ and barrier paradigm, we describe the consequences of chronic inflammation and highlight the importance of the mucosae to engage resolving processes to restore epithelial barrier integrity and function. We further discuss the contribution of pre-mRNA alternative splicing to barrier integrity and intestinal homeostasis. Following discussions on current open questions and challenges, we propose a model in which resolution of inflammation represents a key mechanism for the restoration of epithelial integrity and function.

scholarly journals The Protease Allergen Pen c 13 Induces Allergic Airway Inflammation and Changes in Epithelial Barrier Integrity and Function in a Murine Model

2011 ◽  
Vol 286 (30) ◽  
pp. 26667-26679 ◽  
Author(s):  
Jui-Chieh Chen ◽  
Jiing-Guang Chuang ◽  
Yu-Yi Su ◽  
Bor-Luen Chiang ◽  
You-Shuei Lin ◽  
...  
Keyword(s):  
Airway Inflammation ◽  
Murine Model ◽  
Allergic Airway Inflammation ◽  
Epithelial Barrier ◽  
Barrier Integrity ◽  
And Function

scholarly journals Paracrine SPARC signaling dysregulates alveolar epithelial barrier integrity and function in lung fibrosis

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Franco Conforti ◽  
Robert Ridley ◽  
Christopher Brereton ◽  
Aiman Alzetani ◽  
Benjamin Johnson ◽  
...  
Keyword(s):  
Lung Fibrosis ◽  
Epithelial Barrier ◽  
Barrier Integrity ◽  
Alveolar Epithelial ◽  
And Function

scholarly journals Regulators of endothelial and epithelial barrier integrity and function in acute lung injury

2009 ◽  
Vol 77 (12) ◽  
pp. 1763-1772 ◽  
Author(s):  
Rudolf Lucas ◽  
Alexander D. Verin ◽  
Stephen M. Black ◽  
John D. Catravas
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Epithelial Barrier ◽  
Barrier Integrity ◽  
And Function

scholarly journals Regulation of bronchial epithelial barrier integrity by type 2 cytokines and histone deacetylases in asthmatic patients

2017 ◽  
Vol 139 (1) ◽  
pp. 93-103 ◽  
Author(s):  
Paulina Wawrzyniak ◽  
Marcin Wawrzyniak ◽  
Kerstin Wanke ◽  
Milena Sokolowska ◽  
Kreso Bendelja ◽  
...  
Keyword(s):  
Histone Deacetylases ◽  
Epithelial Barrier ◽  
Bronchial Epithelial ◽  
Barrier Integrity ◽  
Asthmatic Patients ◽  
Type 2 Cytokines

scholarly journals Raised intensity phonation compromises vocal fold epithelial barrier integrity

2011 ◽  
Vol 121 (2) ◽  
pp. 346-351 ◽  
Author(s):  
Bernard Rousseau ◽  
Atsushi Suehiro ◽  
Nicholas Echemendia ◽  
Mahalakshmi Sivasankar
Keyword(s):  
Vocal Fold ◽  
Epithelial Barrier ◽  
Barrier Integrity
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