scholarly journals Expression of the filaggrin gene in umbilical cord blood predicts eczema risk in infancy: A birth cohort study

2017 ◽  
Vol 47 (9) ◽  
pp. 1185-1192 ◽  
Author(s):  
A. H. Ziyab ◽  
S. Ewart ◽  
G. A. Lockett ◽  
H. Zhang ◽  
H. Arshad ◽  
...  
2021 ◽  
Author(s):  
Monica Seefelder de Assis Araujo ◽  
Nataly Damasceno de figueiredo ◽  
Jorge Fonte de Rezende Flho ◽  
Joffre Amim Junior ◽  
Marlos Melo Martins ◽  
...  

Abstract The PIPA Project is a prospective birth cohort study based in Rio de Janeiro, Brazil, whose pilot study was carried out between October 2017 and August 2018. Arsenic (As), cadmium (Cd), lead (Pb), and mercury (Hg) concentrations were determined in maternal (n = 49) and umbilical cord blood (n = 46). The Denver Developmental Screening Test II (DDST-II) was applied in 50 six-month-old infants. Metals were detected in 100% of the mother and newborn samples above the limits of detection. Maternal blood lead concentrations were higher in premature newborns (GM: 5.72 µg/dL; p = 0.05). One-third of the infants (17–33%) exhibited at least one fail in the neurodevelopment evaluation (fail group). Maternal blood arsenic concentrations were significantly (p = 0.02) higher in the "fail group" (GM: 11.85 µg /L) compared to infants who did not fail (not fail group) (GM: 8.46 µg /L). Maternal and umbilical cord blood arsenic concentrations were higher in all Denver Test’s domains (except personal/social) in the “fail group”, albeit non-statistically significant. These findings indicate the need to further investigate the toxic effects of prenatal exposure to metals on infant neurodevelopment.


2016 ◽  
Vol 95 (4) ◽  
pp. 817-826 ◽  
Author(s):  
Elizabeth B. Brickley ◽  
Patrick E. Duffy ◽  
Robert Morrison ◽  
Edward Kabyemela ◽  
Michal Fried ◽  
...  

2009 ◽  
Vol 20 (3) ◽  
pp. 219-226 ◽  
Author(s):  
Luregn Jan Schlapbach ◽  
Philipp Latzin ◽  
Nicolas Regamey ◽  
Claudia E. Kuehni ◽  
Marcel Zwahlen ◽  
...  

PLoS ONE ◽  
2018 ◽  
Vol 13 (7) ◽  
pp. e0200236 ◽  
Author(s):  
Marco Patrick Lurà ◽  
Olga Gorlanova ◽  
Loretta Müller ◽  
Elena Proietti ◽  
Danielle Vienneau ◽  
...  

2018 ◽  
Vol 221 (6) ◽  
pp. 876-882 ◽  
Author(s):  
Jillian Ashley-Martin ◽  
Linda Dodds ◽  
Tye E. Arbuckle ◽  
Adrienne S. Ettinger ◽  
Gabriel D. Shapiro ◽  
...  

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Bo Y. Park ◽  
Brian K. Lee ◽  
Igor Burstyn ◽  
Loni P. Tabb ◽  
Jeff A. Keelan ◽  
...  

2020 ◽  
Vol 40 (12) ◽  
Author(s):  
Joy Y. Zhang ◽  
Jing Wang ◽  
Qinsheng Lu ◽  
Meizhen Tan ◽  
Ru Wei ◽  
...  

Abstract Iron stores at birth are essential to meet iron needs during the first 4–6 months of life. The present study aimed to investigate iron stores in normal birth weight, healthy, term neonates. Umbilical cord blood samples were collected from apparently normal singleton vaginal deliveries (n=854). Subjects were screened and excluded if C-reactive protein (CRP) > 5 mg/l or α1-acid glycoprotein (AGP) > 1 g/l, preterm (<37 complete weeks), term < 2500g or term > 4000g. In total, 762 samples were included in the study. Serum ferritin, soluble transferrin receptor (sTfR), hepcidin, and erythropoietin (EPO) were measured in umbilical cord blood samples; total body iron (TBI) (mg/kg) was calculated using sTfR and ferritin concentrations. A total of 19.8% newborns were iron deficient (ferritin 35 μg/l) and an additional 46.6% had insufficient iron stores (ferritin < 76 μg/l). There was a positive association between serum ferritin and sTfR, hepcidin, and EPO. Gestational age was positively associated with ferritin, sTfR, EPO, and hepcidin. In conclusion, we demonstrate a high prevalence of insufficient iron stores in a Chinese birth cohort. The value of cord sTfR and TBI in the assessment of iron status in the newborn is questionable, and reference ranges need to be established.


Sign in / Sign up

Export Citation Format

Share Document