Regulation of IgE-mediated signalling in human basophils by CD32b and its role in Syk down-regulation

2014 ◽  
Vol 44 (5) ◽  
pp. 713-723 ◽  
Author(s):  
D. MacGlashan ◽  
G. Moore ◽  
U. Muchhal
Keyword(s):  
Down Regulation ◽  
Ige Mediated ◽  
Human Basophils

scholarly journals Enhancement of IgE-mediated histamine release from human basophils by viruses: role of interferon.

1977 ◽  
Vol 145 (4) ◽  
pp. 892-906 ◽  
Author(s):  
S Ida ◽  
J J Hooks ◽  
R P Siraganian ◽  
A L Notkins
Keyword(s):  
Tissue Culture ◽  
Antiviral Activity ◽  
Histamine Release ◽  
Influenza A ◽  
Culture Fluid ◽  
Soluble Factor ◽  
Release Histamine ◽  
Ige Mediated ◽  
Human Basophils

Human leukocytes maintained in culture are induced to release histamine when exposed to ragweed antigen E or anti-IgE. Leukocyte cultures incubated with virus (i.e. HSV-1, Influenza A, and Adeno-1) but not exposed to ragweed antigen E or anti-IgE fail to release histamine. If, however, leukocyte cultures are first exposed to virus and then to ragweed antigen E or anti-IgE, significant enhancement of histamine release occurs. Both infectious and inactivated virus enhance histamine release and the degree of enhancement is related to the concentration of virus and the length of the incubation. Tissue culture fluid harvested 8 h after exposure of leukocytes to virus contains a soluble factor which is capable of enhancing histamine release when added to fresh leukocyte cultures. This factor has all the properties of interferon including species specificity and cannot be dissociated from the antiviral activity of interferon. Moreover, both known inducers of interferon (poly I:poly C) and standard preparations of interferon are capable of enhancing histamine release. The enhancement of histamine release by interferon represents a new biological role for interferon.

Superallergens: a novel mechanism of IgE-mediated activation of human basophils and mast cells

2004 ◽  
Vol 4 (s2) ◽  
pp. 64-75 ◽  
Author(s):  
G. Marone ◽  
F. W. Rossi ◽  
M. Bova ◽  
A. Detoraki ◽  
B. Liccardo ◽  
...  
Keyword(s):  
Mast Cells ◽  
Ige Mediated ◽  
Human Basophils

LAMP1 and CD63 Expression In Mouse Mast Cells and Human Basophils Rendered Hyporesponsive By Antigen/IgE-Mediated Activation and Desensitization

2014 ◽  
Vol 133 (2) ◽  
pp. AB59 ◽  
Author(s):  
Pedro Giavina-Bianchi ◽  
Matthieu Picard ◽  
Joana Caiado ◽  
Veronica Mezzano ◽  
Mariana C. Castells
Keyword(s):  
Mast Cells ◽  
Ige Mediated ◽  
Human Basophils ◽  
Cd63 Expression
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