scholarly journals The neural correlates of working memory training in typically developing children

2021 ◽  
Author(s):  
Jonathan S. Jones ◽  
Anna‐Lynne R. Adlam ◽  
Abdelmalek Benattayallah ◽  
Fraser N. Milton
Keyword(s):  
Working Memory ◽  
Neural Correlates ◽  
Working Memory Training ◽  
Memory Training ◽  
Typically Developing ◽  
Typically Developing Children

scholarly journals The Neural Correlates of Working Memory Training in Typically Developing Children

2021 ◽  
Author(s):  
Jonathan S Jones ◽  
Anna-Lynne R Adlam ◽  
Abdelmalek Benattayallah ◽  
Fraser N Milton
Keyword(s):  
Working Memory ◽  
Functional Connectivity ◽  
Memory Performance ◽  
Neural Correlates ◽  
Working Memory Training ◽  
Memory Training ◽  
Typically Developing ◽  
Typically Developing Children ◽  
Complex Span ◽  
Randomised Controlled

Working memory training improves cognitive performance on untrained tasks; however, little is known about the underlying neural mechanisms, particularly in childhood where neuroplasticity may be greatest. The neural correlates of working memory training were investigated in 32 typically developing children aged 10-14 years (19 girls and 13 boys; Devon, UK) using a randomised controlled design and multi-modal MRI. Training improved working memory performance and increased intrinsic functional connectivity within the dorsal attention network. Furthermore, improvements in working memory were associated with greater recruitment of the left middle frontal gyrus during a complex span task. The repeated engagement of fronto-parietal regions during training may increase their activity and functional connectivity over time, affording greater attentional control on working memory tasks.

Working memory training improves reading processes in typically developing children

2012 ◽  
Vol 18 (1) ◽  
pp. 62-78 ◽  
Author(s):  
Sandra V. Loosli ◽  
Martin Buschkuehl ◽  
Walter J. Perrig ◽  
Susanne M. Jaeggi
Keyword(s):  
Working Memory ◽  
Working Memory Training ◽  
Memory Training ◽  
Typically Developing ◽  
Typically Developing Children ◽  
Reading Processes

scholarly journals Neural correlates of working memory training: Evidence for plasticity in older adults

NeuroImage ◽  
2020 ◽  
Vol 217 ◽  
pp. 116887 ◽  
Author(s):  
Alexandru D. Iordan ◽  
Katherine A. Cooke ◽  
Kyle D. Moored ◽  
Benjamin Katz ◽  
Martin Buschkuehl ◽  
...  
Keyword(s):  
Older Adults ◽  
Working Memory ◽  
Neural Correlates ◽  
Working Memory Training ◽  
Memory Training

scholarly journals Working memory training increases neural efficiency in Parkinson’s disease: a randomized controlled trial

2020 ◽  
Vol 2 (2) ◽  
Author(s):  
Kathrin Giehl ◽  
Anja Ophey ◽  
Jochen Hammes ◽  
Sarah Rehberg ◽  
Thorsten Lichtenstein ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Working Memory ◽  
Parkinson's Disease ◽  
Functional Connectivity ◽  
Controlled Trial ◽  
Memory Task ◽  
Neural Correlates ◽  
Working Memory Training ◽  
Memory Training ◽  
Memory Processes

Abstract Impairment of working memory and executive functions is already frequently observed in early stages of Parkinson’s disease. Improvements in working memory performance in this cohort could potentially be achieved via working memory training. However, the specific neural mechanisms underlying different working memory processes such as maintenance as opposed to manipulation are largely under-investigated in Parkinson’s disease. Moreover, the plasticity of these correlates as a function of working memory training is currently unknown in this population. Thus, the working memory subprocesses of maintenance and manipulation were assessed in 41 cognitively healthy patients with Parkinson’s disease using a newly developed working memory paradigm and functional MRI. Nineteen patients were randomized to a 5-week home-based digital working memory training intervention while the remaining patients entered a control, wait list condition. Working memory task-related activation patterns and context-dependent functional connectivity, as well as the change of these neural correlates as a function of training, were assessed. While both working memory processes activated an extended frontoparietal–cerebellar network, only the manipulation of items within working memory also recruited the anterior striatum. The intervention effect on the neural correlates was small, but decreased activation in areas relevant for working memory could be observed, with activation changes correlating with behavioural change. Moreover, training seemed to result in decreased functional connectivity when pure maintenance was required, and in a reorganization of functional connectivity when items had to be manipulated. In accordance with the neural efficacy hypothesis, training resulted in overall reduced activation and reorganized functional connectivity, with a differential effect on the different working memory processes under investigation. Now, larger trials including follow-up examinations are needed to further explore the long-term effects of such interventions on a neural level and to estimate the clinical relevance to potentially delay cognitive decline in cognitively healthy patients with Parkinson’s disease.

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