Synthesis and antiviral activity of 2′‐deoxy‐6′‐substituted carbocyclic nucleosides

2021 ◽  
Author(s):  
Haitao Xue ◽  
Shuang Guo ◽  
Tianwen Hu ◽  
Daibao Wei ◽  
Yuanchao Xie ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Carbocyclic Nucleosides

Synthesis and Antiviral Activity of Carbocyclic Nucleosides Incorporating a Modified Cyclopentane Ring. Part 3: Adenosine and Uridine Analogues

1999 ◽  
Vol 18 (10) ◽  
pp. 2253-2263 ◽  
Author(s):  
M. Isabel Nieto ◽  
J. Manuel Blanco ◽  
Olga Caamaño ◽  
Franco Fernández ◽  
Xerardo Garcia-mera ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Carbocyclic Nucleosides ◽  
Cyclopentane Ring

SYNTHESIS AND EVALUATION OF ANTIVIRAL ACTIVITY OF HIGHER HOMOLOGUES OF XYLO-CARBOCYCLIC NUCLEOSIDES

2001 ◽  
Vol 20 (4-7) ◽  
pp. 1137-1139 ◽  
Author(s):  
O. Caamaño ◽  
M. J. Figueira ◽  
F. Fernández ◽  
M. D. García ◽  
M. I. Nieto ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Carbocyclic Nucleosides

scholarly journals Syntheses of Isoxazoline-Carbocyclic Nucleosides and Their Antiviral Evaluation: A Standard Protocol

2014 ◽  
Vol 2014 ◽  
pp. 1-12 ◽  
Author(s):  
Paolo Quadrelli ◽  
Naiara Vazquez Martinez ◽  
Roberto Scrocchi ◽  
Antonino Corsaro ◽  
Venerando Pistarà
Keyword(s):  
Antiviral Activity ◽  
Rna Viruses ◽  
Carbocyclic Nucleosides ◽  
Standard Protocol ◽  
Dna And Rna ◽  
Biological Tests ◽  
Key Steps ◽  
The Way

The current synthesis of racemic purine and pyrimidine isoxazoline-carbocyclic nucleosides is reported, detailing the key-steps for standard and reliable preparations. Improved yields were obtained by the proper tuning of the single synthetic steps, opening the way for the preparation of a variety of novel compounds. Some of the obtained compounds were also evaluated against a wide variety of DNA and RNA viruses including HIV. No specific antiviral activity was observed in the cases at hand. Novel compounds were prepared for future biological tests.

ChemInform Abstract: Synthesis of Novel Carbocyclic Nucleosides with a Modified Cyclopentane Ring and Evaluation of Their Antiviral Activity

ChemInform ◽  
2010 ◽  
Vol 30 (41) ◽  
pp. no-no
Author(s):  
Isabel Nieto ◽  
M. Jose Figueira ◽  
J. Manuel Blanco ◽  
Olga Caamano ◽  
Franco Fernandez ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Carbocyclic Nucleosides ◽  
Cyclopentane Ring

ChemInform Abstract: Synthesis and Evaluation of Antiviral Activity of Higher Homologues of Xylo-carbocyclic Nucleosides

ChemInform ◽  
2010 ◽  
Vol 32 (49) ◽  
pp. no-no
Author(s):  
O. Caamano ◽  
M. J. Figueira ◽  
F. Fernandez ◽  
M. D. Garcia ◽  
M. I. Nieto ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Carbocyclic Nucleosides

Synergistic Antiviral Activity of Inhibitors of S-Adenosylhomocysteine Hydrolase and Ribavirin

1993 ◽  
Vol 4 (2) ◽  
pp. 127-130 ◽  
Author(s):  
H. Ishii ◽  
M. Hasobe ◽  
J. G. McKee ◽  
D. B. Ault-Riché ◽  
R. T. Borchardt
Keyword(s):  
Antiviral Activity ◽  
Synergistic Effects ◽  
Cellular Level ◽  
Carbocyclic Nucleosides ◽  
Viral Mrna ◽  
Antiviral Action ◽  
Cellular Toxicity ◽  
Imp Dehydrogenase ◽  
Adenosylhomocysteine Hydrolase ◽  
Antiviral Effects

(1′R,2′S,3′R)-9-(2′,3′-Dihydroxycycloperrt-4′-en-1′-yl)-adenine (DHCeA) and -3-deazaadenine (3-deaza-DHCeA), which are potent inhibitors of S-adenosylho-mocysteine (AdoHcy) hydrolase, and ribavirin, which is an inhibitor of IMP-dehydrogenase, were found in this study to have synergistic effects on inhibiting vaccinia virus replication in murine L929 cells without creating a synergistic effect on cellular toxicity. Thus, the antiviral effectiveness of this drug combination was 5–10× higher than the antiviral effectiveness observed with the AdoHcy hydrolase inhibitors alone. Ribavirin does not alter the ability of DHCeA and 3-deaza-DHCeA to elevate the intracellular AdoHcy/S-adeno-sylmethionine (AdoMet) ratio. Increases in this ratio were shown earlier to correlate with the antiviral effects of these carbocyclic nucleosides. Ribavirin was also shown to significantly reduce the cellular level of GTP, which is consistent with its activity as an inhibitor of IMP-dehydrogenase and its proposed mechanism of antiviral action, inhibiting the formation of the ‘capped methylated structure’ at the 5′-end of viral mRNA.

Cyclopentene carbocyclic nucleosides related to the antitumor nucleoside clitocine and their conversion to 8-Aza-neplanocin analogues. Synthesis and antiviral activity

1993 ◽  
Vol 30 (5) ◽  
pp. 1393-1398 ◽  
Author(s):  
Victor E. Marquez ◽  
Benjamin B. Lim ◽  
John S. Driscoll ◽  
Robert Snoek ◽  
Jan Balzarini ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Carbocyclic Nucleosides
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