Preparation and biological evaluation of new antimicrotubule agents: modification of the imidazolidin‐2‐one moiety of phenyl 4‐(2‐oxoimidazolidin‐1‐yl)benzenesulfonates

2021 ◽  
Author(s):  
Mathieu Gagné‐Boulet ◽  
Chahrazed Bouzriba ◽  
Atziri Corin Chavez Alvarez ◽  
Sébastien Fortin
Keyword(s):  
Biological Evaluation ◽  
Antimicrotubule Agents

Antitumor Agents 155. Synthesis and Biological Evaluation of 3',6,7-Substituted 2-Phenyl-4-quinolones as Antimicrotubule Agents

1994 ◽  
Vol 37 (20) ◽  
pp. 3400-3407 ◽  
Author(s):  
Leping Li ◽  
Hui-Kang Wang ◽  
Sheng-Chu Kuo ◽  
Tian-Shung Wu ◽  
Anthony Mauger ◽  
...  
Keyword(s):  
Antitumor Agents ◽  
Biological Evaluation ◽  
Antimicrotubule Agents ◽  
Synthesis And Biological Evaluation

scholarly journals Synthesis, biological evaluation, and molecular modeling of 3,5-substituted-N1-phenyl-N4,N4-di-n-butylsulfanilamides as antikinetoplastid antimicrotubule agents

2007 ◽  
Vol 15 (18) ◽  
pp. 6071-6079 ◽  
Author(s):  
Tesmol G. George ◽  
Molla M. Endeshaw ◽  
Rachel E. Morgan ◽  
Kiran V. Mahasenan ◽  
Dawn A. Delfín ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Biological Evaluation ◽  
Antimicrotubule Agents

Chemical and biological evaluation of native bamboo species from atlantic rain forest

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
MT Grombone-Guaratini ◽  
LM Brandão Torres ◽  
DA Faria ◽  
CM José
Keyword(s):  
Rain Forest ◽  
Biological Evaluation ◽  
Atlantic Rain Forest ◽  
Bamboo Species

SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF 3-FORMYL INDOLE BASED SCHIFF BASES

2018 ◽  
Vol 7 (6) ◽  
Author(s):  
Singh Gurvinder ◽  
Singh Prabhsimran ◽  
Dhawan R. K.
Keyword(s):  
Antimicrobial Activity ◽  
Spectral Analysis ◽  
Schiff Bases ◽  
Antimicrobial Agents ◽  
Biological Evaluation ◽  
Fungal Strain ◽  
Bacterial Strains ◽  
Standard Drug ◽  
Gram Negative ◽  
E Coli

In order to develop new antimicrobial agents, a series of 3-formyl indole based Schiff bases were synthesized by reacting 3-formyl indole(indole-3-carboxaldehyde) with substituted aniline taking ethanol as solvent. The reaction was carried in the presence of small amount of p-toluene sulphonic acid as catalyst.All the synthesized compounds were characterized by IR, 1H-NMR spectral analysis. All the synthesized compounds were evaluated for antimicrobial activity against two gram positive bacterial strains (B. subtilisand S. aureus) and two gram negative bacterial strains (P. aeruginosaand E. coli) and one fungal strain (C. albicans). All the synthesized compounds were found to have moderate to good antimicrobial activity. The  standard drug amoxicillin, fluconazole were used for antimicrobial activity. Among the synthesized compounds, the maximum antimicrobial activity was shown by compounds GS04, GS07, GS08 and GS10.

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