scholarly journals Structural improvement of new thiazolidinones compounds with antinociceptive activity in experimental chemotherapy-induced painful neuropathy

2017 ◽  
Vol 90 (2) ◽  
pp. 297-307 ◽  
Author(s):  
Diogo Rodrigo Magalhaes Moreira ◽  
Dourivaldo Silva Santos ◽  
Renan Fernandes do Espírito Santo ◽  
Flávia Evangelista dos Santos ◽  
Gevanio Bezerra de Oliveira Filho ◽  
...  
Keyword(s):  
Antinociceptive Activity ◽  
Painful Neuropathy ◽  
Experimental Chemotherapy ◽  
Structural Improvement

Structural improvement of compounds with analgesic activity: AC-MPF4, a compound with mixed anti-inflammatory and antinociceptive activity via opioid receptor

2015 ◽  
Vol 129 ◽  
pp. 72-78 ◽  
Author(s):  
Mateus Fortes Rossato ◽  
Sara Marchesan Oliveira ◽  
Gabriela Trevisan ◽  
Mariane Rotta ◽  
Pablo Machado ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Analgesic Activity ◽  
Antinociceptive Activity ◽  
Structural Improvement ◽  
Anti Inflammatory

Lacistema pubescens Mart.: A species with antinociceptive activity

2017 ◽  
Author(s):  
J Conegundes ◽  
F Fernandes Maria ◽  
R Mendes ◽  
N Pinto ◽  
J Silva ◽  
...  
Keyword(s):  
Antinociceptive Activity

PAINFUL NEUROPATHY DECREASES MEMBRANE CALCIUM CURRENT IN MAMMALIAN PRIMARY AFFERENT NEURONS

2000 ◽  
Vol 5 (4) ◽  
pp. 245-245
Author(s):  
Qh Hogan ◽  
Jb McCallum ◽  
C Sarantopoulos ◽  
M Aason ◽  
M Mynlieff ◽  
...  
Keyword(s):  
Calcium Current ◽  
Afferent Neurons ◽  
Painful Neuropathy ◽  
Primary Afferent Neurons ◽  
Primary Afferent

scholarly journals Anti-nociceptive and anti-inflammatory effects of an aqueous extract of blended leaves of Ocimum gratissimum and Psidium guajava

2019 ◽  
Vol 5 (1) ◽  
Author(s):  
Akinyinka O. Alabi ◽  
Abayomi M. Ajayi ◽  
Osarume Omorogbe ◽  
Solomon Umukoro
Keyword(s):  
Acetic Acid ◽  
Aqueous Extract ◽  
Psidium Guajava ◽  
Antinociceptive Activity ◽  
Hot Plate ◽  
Hot Plate Test ◽  
Promising Alternative ◽  
Plate Test ◽  
Ocimum Gratissimum ◽  
Anti Inflammatory

Abstract Background To investigate the antinociceptive and anti-inflammatory activities of aqueous extract of a blended mixture of dried leaves of Ocimum gratissimum and Psidium guajava, a traditional analgesic drug polyherbal (TADP) used as a remedy for pain-related conditions. Methods Antinociceptive activity of TADP (100, 200 and 400 mg/kg) was evaluated in the hot plate test and acetic acid-induced nociception in mice while the anti-inflammatory was evaluated in carrageenan-induced paw oedema in rats. Levels of nitrite, myeloperoxidase, glutathione and malondialdehyde were assayed in carrageenan-induced paw tissue. Results TADP (200 and 400 mg/kg) significantly prolong the latency time in the hot-plate test. TADP (100–400 mg/kg) produced a dose-dependent significant inhibition of the acetic-acid induced abdominal constriction. The antinociceptive activity of TADP in the presence of naloxone and atropine was not reversed whereas yohimbine and glibenclamide significantly reversed it. TADP (100, 200 and 400 mg/kg) significantly reduced the swelling in the carrageenan-induced oedema model and also produced a reduction in the nitrite and myeloperoxidase level. TADP (400 mg/kg) significantly reduced malondialdehyde concentration and increase glutathione level in the carrageenan-induced rat paw. TADP significantly decrease the number of cellular infiltrates in the histopathological assessment. Conclusion These results indicate that polyherbal product containing blended leaves of Ocimum gratissimum and Psidium guajava possess antinociceptive and anti-inflammatory properties, hence represents a promising alternative remedy in inflammation-induced pain.

scholarly journals Sustainable development and enhancement of cracking processes using metallic composites

2021 ◽  
Author(s):  
Abimbola G. Olaremu ◽  
Williams R. Adedoyin ◽  
Odunayo T. Ore ◽  
Adedapo O. Adeola
Keyword(s):  
Crude Oil ◽  
Environmental Sustainability ◽  
Catalytic Cracking ◽  
Environmental Concern ◽  
Sustainable Use ◽  
Comprehensive Overview ◽  
Support Materials ◽  
Catalytic Support ◽  
Structural Improvement ◽  
Metallic Composites

AbstractMetallic composites represent a vital class of materials that has gained increased attention in crude oil processing as well as the production of biofuel from other sources in recent times. Several catalytic materials have been reported in the literature for catalytic cracking, particularly, of crude oil. This review seeks to provide a comprehensive overview of existing and emerging methods/technologies such as metal–organic frameworks (MOFs), metal–matrix composites (MMCs), and catalytic support materials, to bridge information gaps toward sustainable advancement in catalysis for petrochemical processes. There is an increase in industrial and environmental concern emanating from the sulphur levels of oils, hence the need to develop more efficient catalysts in the hydrotreatment (HDS and HDN) processes, and combating the challenge of catalyst poisoning and deactivation; in a bid to improving the overall quality of oils and sustainable use of catalyst. Structural improvement, high thermal stability, enhanced cracking potential, and environmental sustainability represent the various benefits accrued to the use of metallic composites as opposed to conventional catalysts employed in catalytic cracking processes.

Nalbuphine could decrease the rewarding effect induced by tramadol in mice while enhancing its antinociceptive activity

2015 ◽  
Vol 758 ◽  
pp. 11-15 ◽  
Author(s):  
Rasha Abdel-Ghany ◽  
Mahmoud Nabil ◽  
Mohamed Abdel-Aal ◽  
Waleed Barakat
Keyword(s):  
Antinociceptive Activity ◽  
Rewarding Effect
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