Design, synthesis and pharmacophoric model building of new 3-alkoxymethyl/3-phenyl indole-2-carboxamides with potential antiproliferative activity

2017 ◽  
Vol 90 (1) ◽  
pp. 64-82 ◽  
Author(s):  
Mostafa H. Abdelrahman ◽  
Ahmed S. Aboraia ◽  
Bahaa G. M. Youssif ◽  
Bakheet E. M. Elsadek
Keyword(s):  
Antiproliferative Activity ◽  
Model Building ◽  
Design Synthesis ◽  
Pharmacophoric Model

Design, synthesis and pharmacophoric model building of novel substituted nicotinic acid hydrazones with potential antiproliferative activity

2012 ◽  
Vol 35 (9) ◽  
pp. 1543-1552 ◽  
Author(s):  
Hatem A. Abdel-Aziz ◽  
Tarek Aboul-Fadl ◽  
Abdul-Rahman M. Al-Obaid ◽  
Mohamed Ghazzali ◽  
Abdullah Al-Dhfyan ◽  
...  
Keyword(s):  
Nicotinic Acid ◽  
Antiproliferative Activity ◽  
Model Building ◽  
Design Synthesis ◽  
Pharmacophoric Model

Design, Synthesis, and In Vitro Evaluation of Tubulin‐targeting Dibenzothiazines with Antiproliferative Activity as Novel Heterocycle Building Block

ChemMedChem ◽  
2021 ◽  
Author(s):  
Walter Damián Guerra ◽  
Daniel Lucena-Agell ◽  
Rafael Hortigüela ◽  
Roberto Arturo Rossi ◽  
J. Fernando Díaz ◽  
...  
Keyword(s):  
Antiproliferative Activity ◽  
Building Block ◽  
Design Synthesis ◽  
In Vitro Evaluation

Design, synthesis and antiproliferative activity evaluation of fluorine-containing chalcone derivatives

2020 ◽  
pp. 1-26
Author(s):  
Serdar Burmaoglu ◽  
Derya Aktas Anil ◽  
Arzu Gobek ◽  
Deryanur Kilic ◽  
Derya Yetkin ◽  
...  
Keyword(s):  
Antiproliferative Activity ◽  
Design Synthesis ◽  
Chalcone Derivatives ◽  
Activity Evaluation

scholarly journals Discovery of Novel Non-Steroidal Cytochrome P450 17A1 Inhibitors as Potential Prostate Cancer Agents

2020 ◽  
Vol 21 (14) ◽  
pp. 4868
Author(s):  
Tomasz M. Wróbel ◽  
Oksana Rogova ◽  
Kasper L. Andersen ◽  
Rahul Yadav ◽  
Simone Brixius-Anderko ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cytochrome P450 ◽  
Cell Lines ◽  
Antiproliferative Activity ◽  
Enzyme Inhibitors ◽  
Prostate Cancer Cell ◽  
Binding Mode ◽  
Prostate Cancer Cell Lines ◽  
Design Synthesis ◽  
Key Enzyme

The current study presents the design, synthesis, and evaluation of novel cytochrome P450 17A1 (CYP17A1) ligands. CYP17A1 is a key enzyme in the steroidogenic pathway that produces androgens among other steroids, and it is implicated in prostate cancer. The obtained compounds are potent enzyme inhibitors (sub µM) with antiproliferative activity in prostate cancer cell lines. The binding mode of these compounds is also discussed.

Design, synthesis and evaluation of antiproliferative activity of fluorinated betulinic acid

2019 ◽  
Vol 27 (13) ◽  
pp. 2871-2882 ◽  
Author(s):  
Jizhen Li ◽  
Ling-Chu Chang ◽  
Kan-Yen Hsieh ◽  
Pei-Ling Hsu ◽  
Stephen J. Capuzzi ◽  
...  
Keyword(s):  
Antiproliferative Activity ◽  
Betulinic Acid ◽  
Design Synthesis
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