Targeting Bacterial Cell Wall Peptidoglycan Synthesis by Inhibition of Glycosyltransferase Activity

2015 ◽  
Vol 87 (2) ◽  
pp. 190-199 ◽  
Author(s):  
Michael F. Mesleh ◽  
Premraj Rajaratnam ◽  
Mary Conrad ◽  
Vasu Chandrasekaran ◽  
Christopher M. Liu ◽  
...  
Keyword(s):  
Cell Wall ◽  
Bacterial Cell ◽  
Bacterial Cell Wall ◽  
Peptidoglycan Synthesis ◽  
Cell Wall Peptidoglycan

The Site of Inhibition of Bacterial Cell Wall Peptidoglycan Synthesis by Azureomycin B, a New Antibiotic1

1980 ◽  
Vol 88 (2) ◽  
pp. 565-570 ◽  
Author(s):  
Priska SPIRI-NAKAGAWA ◽  
Ruiko ÖIWA ◽  
Yoshitake TANAKA ◽  
Haruo TANAKA ◽  
Satoshi ÖMURA
Keyword(s):  
Cell Wall ◽  
Bacterial Cell ◽  
Bacterial Cell Wall ◽  
Peptidoglycan Synthesis ◽  
Cell Wall Peptidoglycan

scholarly journals Three-dimensional structure of the bacterial cell wall peptidoglycan

2006 ◽  
Vol 103 (12) ◽  
pp. 4404-4409 ◽  
Author(s):  
S. O. Meroueh ◽  
K. Z. Bencze ◽  
D. Hesek ◽  
M. Lee ◽  
J. F. Fisher ◽  
...  
Keyword(s):  
Cell Wall ◽  
Bacterial Cell ◽  
Three Dimensional ◽  
Bacterial Cell Wall ◽  
Dimensional Structure ◽  
Three Dimensional Structure ◽  
Cell Wall Peptidoglycan

scholarly journals Bacterial Cell Wall Quality Control during Environmental Stress

mBio ◽  
2020 ◽  
Vol 11 (5) ◽  
Author(s):  
Elizabeth A. Mueller ◽  
Petra Anne Levin
Keyword(s):  
Quality Control ◽  
Cell Wall ◽  
Cell Surface ◽  
Environmental Stress ◽  
Environmental Conditions ◽  
Bacterial Cell ◽  
Cell Shape ◽  
Bacterial Cell Wall ◽  
Peptidoglycan Synthesis ◽  
Peptidoglycan Cell Wall

ABSTRACT Single-celled organisms must adapt their physiology to persist and propagate across a wide range of environmental conditions. The growth and division of bacterial cells depend on continuous synthesis of an essential extracellular barrier: the peptidoglycan cell wall, a polysaccharide matrix that counteracts turgor pressure and confers cell shape. Unlike many other essential processes and structures within the bacterial cell, the peptidoglycan cell wall and its synthesis machinery reside at the cell surface and are thus uniquely vulnerable to the physicochemical environment and exogenous threats. In addition to the diversity of stressors endangering cell wall integrity, defects in peptidoglycan metabolism require rapid repair in order to prevent osmotic lysis, which can occur within minutes. Here, we review recent work that illuminates mechanisms that ensure robust peptidoglycan metabolism in response to persistent and acute environmental stress. Advances in our understanding of bacterial cell wall quality control promise to inform the development and use of antimicrobial agents that target the synthesis and remodeling of this essential macromolecule. IMPORTANCE Nearly all bacteria are encased in a peptidoglycan cell wall, an essential polysaccharide structure that protects the cell from osmotic rupture and reinforces cell shape. The integrity of this protective barrier must be maintained across the diversity of environmental conditions wherein bacteria replicate. However, at the cell surface, the cell wall and its synthesis machinery face unique challenges that threaten their integrity. Directly exposed to the extracellular environment, the peptidoglycan synthesis machinery encounters dynamic and extreme physicochemical conditions, which may impair enzymatic activity and critical protein-protein interactions. Biotic and abiotic stressors—including host defenses, cell wall active antibiotics, and predatory bacteria and phage—also jeopardize peptidoglycan integrity by introducing lesions, which must be rapidly repaired to prevent cell lysis. Here, we review recently discovered mechanisms that promote robust peptidoglycan synthesis during environmental and acute stress and highlight the opportunities and challenges for the development of cell wall active therapeutics.

Design and evaluation of analogues of the bacterial cell-wall peptidoglycan motif l-Lys-d-Ala-d-Ala for use in a vancomycin biosensor

2007 ◽  
Vol 17 (21) ◽  
pp. 5758-5762 ◽  
Author(s):  
Olivier Hernout ◽  
Karine Berthoin ◽  
Isabelle Delattre ◽  
Paul M. Tulkens ◽  
Stéphane Carryn ◽  
...  
Keyword(s):  
Cell Wall ◽  
Bacterial Cell ◽  
Bacterial Cell Wall ◽  
Cell Wall Peptidoglycan

scholarly journals Characterization of Colicin M and its Orthologs Targeting Bacterial Cell Wall Peptidoglycan Biosynthesis

2012 ◽  
Vol 18 (3) ◽  
pp. 222-229 ◽  
Author(s):  
Hélène Barreteau ◽  
Meriem El Ghachi ◽  
Aurélie Barnéoud-Arnoulet ◽  
Emmanuelle Sacco ◽  
Thierry Touzé ◽  
...  
Keyword(s):  
Cell Wall ◽  
Bacterial Cell ◽  
Bacterial Cell Wall ◽  
Peptidoglycan Biosynthesis ◽  
Cell Wall Peptidoglycan ◽  
Colicin M

Interactions of plant lectins with the components of the bacterial cell wall peptidoglycan

1994 ◽  
Vol 22 (2) ◽  
pp. 153-159 ◽  
Author(s):  
Ahidjo Ayouba ◽  
Henri Causse ◽  
Els J.M. Van Damme ◽  
Willy J. Peumans ◽  
Yves Bourne ◽  
...  
Keyword(s):  
Cell Wall ◽  
Bacterial Cell ◽  
Bacterial Cell Wall ◽  
Plant Lectins ◽  
Cell Wall Peptidoglycan
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