Synthesis and Biological Evaluation of [1,2,4]Triazolo[3,4-a]phthalazine and Tetrazolo[5,1-a]phthalazine Derivatives Bearing Substituted Benzylpiperazine Moieties as Positive Inotropic Agents

2013 ◽  
Vol 81 (5) ◽  
pp. 591-599 ◽  
Author(s):  
Yan Wu ◽  
Liang-Peng Sun ◽  
Long-Xu Ma ◽  
Jian Che ◽  
Ming-Xia Song ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Inotropic Agents ◽  
Positive Inotropic Agents ◽  
Synthesis And Biological Evaluation

scholarly journals Synthesis and Biological Evaluation of Liguzinediol Mono- and Dual Ester Prodrugs as Promising Inotropic Agents

Molecules ◽  
2014 ◽  
Vol 19 (11) ◽  
pp. 18057-18072 ◽  
Author(s):  
Jing Zhang ◽  
Wei Li ◽  
Hong-Mei Wen ◽  
Hao-Hao Zhu ◽  
Tian-Lin Wang ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Inotropic Agents ◽  
Synthesis And Biological Evaluation ◽  
Ester Prodrugs

Synthesis and Biological Evaluation of the Antimicrobial Natural Product Lipoxazolidinone A

2018 ◽  
Author(s):  
Jonathan J. Mills ◽  
Kaylib R. Robinson ◽  
Troy E. Zehnder ◽  
Joshua G. Pierce
Keyword(s):  
Natural Products ◽  
Natural Product ◽  
Mechanism Of Action ◽  
Marine Natural Products ◽  
Biological Evaluation ◽  
Lead Compounds ◽  
Follow Up Studies ◽  
Initial Resistance ◽  
Synthesis And Biological Evaluation

The lipoxazolidinone family of marine natural products, with an unusual 4-oxazolidinone heterocycle at their core, represents a new scaffold for antimicrobial discovery; however, questions regarding their mechanism of action and high lipophilicity have likely slowed follow-up studies. Herein, we report the first synthesis of lipoxazolidinone A, 15 structural analogs to explore its active pharmacophore, and initial resistance and mechanism of action studies. These results suggest that 4-oxazolidinones are valuable scaffolds for antimicrobial development and reveal simplified lead compounds for further optimization.

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