scholarly journals Microbial metabolite deoxycholic acid promotes vasculogenic mimicry formation in intestinal carcinogenesis

2021 ◽  
Author(s):  
Xueli Song ◽  
Yaping An ◽  
Danfeng Chen ◽  
Wanru Zhang ◽  
Xuemei Wu ◽  
...  
Keyword(s):  
Deoxycholic Acid ◽  
Vasculogenic Mimicry ◽  
Microbial Metabolite ◽  
Intestinal Carcinogenesis

scholarly journals Microbial metabolite deoxycholic acid shapes microbiota against Campylobacter jejuni chicken colonization

PLoS ONE ◽  
2019 ◽  
Vol 14 (7) ◽  
pp. e0214705 ◽  
Author(s):  
Bilal Alrubaye ◽  
Mussie Abraha ◽  
Ayidh Almansour ◽  
Mohit Bansal ◽  
Hong Wang ◽  
...  
Keyword(s):  
Campylobacter Jejuni ◽  
Deoxycholic Acid ◽  
Microbial Metabolite

scholarly journals Microbial metabolite deoxycholic acid shapes microbiota againstCampylobacter jejunichicken colonization

2019 ◽  
Author(s):  
Bilal Alrubaye ◽  
Mussie Abraha ◽  
Ayidh Almansour ◽  
Mohit Bansal ◽  
Hong Wang ◽  
...  
Keyword(s):  
Campylobacter Jejuni ◽  
Intestinal Tract ◽  
Deoxycholic Acid ◽  
Lithocholic Acid ◽  
Foodborne Pathogen ◽  
Broiler Chicks ◽  
Microbiota Composition ◽  
Microbial Metabolites ◽  
Microbial Metabolite ◽  
Chicken Isolate

ABSTRACTDespite reducing the prevalent foodborne pathogenCampylobacter jejuniin chickens decreases campylobacteriosis, few effective approaches are available. The aim of this study was to use microbial metabolic product bile acids to reduceC. jejunichicken colonization. Broiler chicks were fed with deoxycholic acid (DCA), lithocholic acid (LCA), or ursodeoxycholic acid (UDCA). The birds were also transplanted with DCA modulated anaerobes (DCA-Anaero) or aerobes (DCA-Aero). The birds were infected with human clinical isolateC. jejuni81-176 or chicken isolateC. jejuniAR101. Notably,C. jejuni81-176 was readily colonized intestinal tract at d16 and reached an almost plateau at d21. Remarkably, DCA excludedC. jejunicecal colonization at 100, 99.997, and 100% at 16, 21, and 28 days of age. Neither chicken ages of infection nor LCA or UDCA alteredC. jejuniAR101 chicken colonization level, while DCA reduced 91% of the bacterium in chickens at d28. Notably, DCA diet reduced phylum Firmicutes but increased Bacteroidetes compared to infected control birds. Importantly, DCA-Anaero attenuated 93% ofC. jejunicolonization at d28 compared to control infected birds. In conclusion, DCA shapes microbiota composition againstC. jejunicolonization in chickens, suggesting a bidirectional interaction between microbiota and microbial metabolites.

Microbial Metabolite Deoxycholic Acid Promotes Vasculogenic Mimicry Formation in Intestinal Carcinogenesis

2021 ◽  
Author(s):  
Xueli Song ◽  
Yaping An ◽  
Danfeng Chen ◽  
Wanru Zhang ◽  
Xuemei Wu ◽  
...  
Keyword(s):  
Vasculogenic Mimicry ◽  
Intestinal Carcinogenesis

Baicalein, an enteric microbial metabolite, suppresses gut inflammation and cancer progression in ApcMin/+ mice

2019 ◽  
Vol 22 (7) ◽  
pp. 1013-1022 ◽  
Author(s):  
C.-Z. Wang ◽  
C.-F. Zhang ◽  
Y. Luo ◽  
H. Yao ◽  
C. Yu ◽  
...  
Keyword(s):  
Cancer Progression ◽  
Gut Inflammation ◽  
Microbial Metabolite

scholarly journals Overview on the Different Patterns of Tumor Vascularization

Cells ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 639
Author(s):  
Domenico Ribatti ◽  
Francesco Pezzella
Keyword(s):  
Vasculogenic Mimicry ◽  
Endothelial Cell Proliferation ◽  
Published Data ◽  
Alternative Mechanism ◽  
Tumor Vascularization ◽  
Angiogenic Therapy ◽  
Physiological Processes ◽  
Inhibition Of Angiogenesis ◽  
Therapeutic Development

Angiogenesis is a crucial event in the physiological processes of embryogenesis and wound healing. During malignant transformation, dysregulation of angiogenesis leads to the formation of a vascular network of tumor-associated capillaries promoting survival and proliferation of the tumor cells. Starting with the hypothesis formulated by Judah Folkman that tumor growth is angiogenesis-dependent, this area of research has a solid scientific foundation and inhibition of angiogenesis is a major area of therapeutic development for the treatment of cancer. Over this period numerous authors published data of vascularization of tumors, which attributed the cause of neo-vascularization to various factors including inflammation, release of angiogenic cytokines, vasodilatation, and increased tumor metabolism. More recently, it has been demonstrated that tumor vasculature is not necessarily derived by endothelial cell proliferation and sprouting of new capillaries, but alternative vascularization mechanisms have been described, namely vascular co-option and vasculogenic mimicry. In this article, we have analyzed the mechanisms involved in tumor vascularization in association with classical angiogenesis, including post-natal vasculogenesis, intussusceptive microvascular growth, vascular co-option, and vasculogenic mimicry. We have also discussed the role of these alternative mechanism in resistance to anti-angiogenic therapy and potential therapeutic approaches to overcome resistance.

scholarly journals Metabolism of deoxycholic acid in bile fistula patients

1971 ◽  
Vol 12 (6) ◽  
pp. 688-691
Author(s):  
RUSSELL F. HANSON ◽  
GALE WILLIAMS
Keyword(s):  
Deoxycholic Acid ◽  
Bile Fistula
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