scholarly journals Ferroptosis‐resistance determines high susceptibility of murine A/J strain to iron‐induced renal carcinogenesis

2021 ◽  
Author(s):  
Zhen Cheng ◽  
Shinya Akatsuka ◽  
Guang Hua Li ◽  
Kiyoshi Mori ◽  
Takashi Takahashi ◽  
...  
Keyword(s):  
High Susceptibility ◽  
Renal Carcinogenesis

scholarly journals Differences in susceptibility of marine bacterial communities to metal pyrithiones, their degradation compounds and organotin antifouling biocides

2019 ◽  
Vol 99 (5) ◽  
pp. 1033-1039
Author(s):  
Madoka Ohji ◽  
Hiroya Harino ◽  
William John Langston
Keyword(s):  
Life History ◽  
Degradation Product ◽  
Bacterial Communities ◽  
Degradation Products ◽  
High Susceptibility ◽  
Zinc Pyrithione ◽  
Bacterial Colony ◽  
Indigenous Bacteria ◽  
Antifouling Biocides ◽  
Colony Forming Units

AbstractThe susceptibility of marine bacterial communities to copper pyrithione (CuPT2), zinc pyrithione (ZnPT2) and their degradation product is described and toxicities of these relatively new antifouling biocides compared with those of their harmful organotin (OT) predecessors, tributyltin (TBT) and triphenyltin (TPT). These biocides were added to agar at concentrations of 0, 0.01, 0.1, 1 and 10 mg l−1and coastal seawater including indigenous bacteria added to each batch of agar solution. The number of bacterial colony forming units (CFU) was measured after 7 days culture. Relative CFU (as a percentage of control) was more than 80% at a concentration of 0.01 mg l−1of each compound, except for TBT. Relative CFU decreased as a function of dose of each biocide, although concentration-dependent changes in rate of CFU were relatively low during exposure to degradation products of CuPT2and ZnPT2, pyridineN-oxide (PO) and pyridine-2-sulphonic acid (PSA). Based on comparisons of EC50, TBT was the most bacterio-toxic of the tested compounds (0.2 mg l−1), marginally more so than CuPT2(0.3 mg l−1). Interestingly, EC50values of degradation products of CuPT2and ZnPT2, 2-mercaptopyridineN-oxide (HPT) and 2,2′-dithio-bispyridineN-oxide (PT2) were 0.8 and 0.5 mg l−1, respectively, lower than that of the parent chemical, ZnPT2(1.4 mg l−1). The EC50of PT2was also lower than that of TPT (0.7 mg l−1), implying higher toxicity. Given the overlapping toxicity ranges, these results suggest that marine bacterial communities experience comparably high susceptibility to metal PTs and OTs during their life history.

scholarly journals High Susceptibility for Cystic Fibrosis Human Airway Gland Cells to Produce IL-8 Through the IκB Kinase α Pathway in Response to Extracellular NaCl Content

2000 ◽  
Vol 164 (6) ◽  
pp. 3377-3384 ◽  
Author(s):  
Olivier Tabary ◽  
Sandie Escotte ◽  
Jean Paul Couetil ◽  
Dominique Hubert ◽  
Daniel Dusser ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
High Susceptibility ◽  
Gland Cells ◽  
Human Airway ◽  
Iκb Kinase

scholarly journals High Susceptibility of Lrig1 Sebaceous Stem Cells to TCDD in Mice

2017 ◽  
Vol 161 (1) ◽  
pp. 207-207
Author(s):  
Fabienne Fontao ◽  
Laurent Barnes ◽  
Guerkan Kaya ◽  
Jean-Hilaire Saurat ◽  
Olivier Sorg
Keyword(s):  
Stem Cells ◽  
High Susceptibility

High susceptibility of Mongolian gerbil (Meriones unguiculatus) to Borna disease virus

Vaccine ◽  
1999 ◽  
Vol 17 (5) ◽  
pp. 480-489 ◽  
Author(s):  
Yurie Nakamura ◽  
Takaaki Nakaya ◽  
Katsuro Hagiwara ◽  
Noriko Momiyama ◽  
Yumiko Kagawa ◽  
...  
Keyword(s):  
Disease Virus ◽  
Mongolian Gerbil ◽  
Meriones Unguiculatus ◽  
High Susceptibility ◽  
Borna Disease Virus ◽  
Borna Disease

scholarly journals Transgenic rescue from embryonic lethality and renal carcinogenesis in the Nihon rat model by introduction of a wild-type Bhd gene

Oncogene ◽  
2005 ◽  
Vol 25 (20) ◽  
pp. 2885-2889 ◽  
Author(s):  
Y Togashi ◽  
T Kobayashi ◽  
S Momose ◽  
M Ueda ◽  
K Okimoto ◽  
...  
Keyword(s):  
Rat Model ◽  
Embryonic Lethality ◽  
Wild Type ◽  
Renal Carcinogenesis ◽  
Nihon Rat
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